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Open Access 01-12-2012 | Research

Pathological impairments induced by interstitial implantation of ¹²⁵I Seeds in spinal canal of banna mini-pigs

Authors: Zuozhang Yang, Yongqing Xu, Dakuan Yang, Hongpu Sun, Ruilian Zhao, Jin Zhang, Xiaoxue Wang, Hua Jiang, Lie Xu, Jinlei Zhang

Published in: World Journal of Surgical Oncology | Issue 1/2012

Abstract

Background

Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.

Methods

In present study, ¹²⁵I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.

Results

In this study, a ¹²⁵I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.

Conclusions

Without any protection and operation improvement, ¹²⁵I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.

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Title: Pathological impairments induced by interstitial implantation of 125I Seeds in spinal canal of banna mini-pigs
Authors: Zuozhang Yang
Yongqing Xu
Dakuan Yang
Hongpu Sun
Ruilian Zhao
Jin Zhang
Xiaoxue Wang
Hua Jiang
Lie Xu
Jinlei Zhang
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-10-48

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Pathological impairments induced by interstitial implantation of ¹²⁵I Seeds in spinal canal of banna mini-pigs

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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