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Molecular Cancer
Published in: Molecular Cancer 1/2011

Open Access 01-12-2011 | Review

Metastasis: new perspectives on an old problem

Authors: Sandra Kraljevic Pavelic, Mirela Sedic, Hrvojka Bosnjak, Sime Spaventi, Kresimir Pavelic

Published in: Molecular Cancer | Issue 1/2011

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Abstract

Many hypotheses have been postulated to explain the intricate nature of the metastatic process, but none of them completely accounted for the actual biological and clinical observations. Consequently, metastasis still remains an open issue with only few metastasis-inducing proteins experimentally validated so far. Recently proposed novel metastatic model, where serial and parallel metastatic processes are adequately integrated, might help to bridge the current gap between experimental results and clinical observations. In addition, the identification, isolation and molecular characterization of cancer stem cells, a population of the cells within the tumour mass able to proliferate, self-renew and induce tumorigenesis, will shed new light on the complex molecular events mediating metastasis, invasion and resistance to therapy. Understanding the molecular basis of these tumour characteristics will usher in a new age of individualized cancer therapy. In this review article, we will provide a current overview of molecular mechanisms underpinning metastasis, and discuss recent findings in this field obtained by global molecular profiling strategies such as proteomics.
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Metadata
Title
Metastasis: new perspectives on an old problem
Authors
Sandra Kraljevic Pavelic
Mirela Sedic
Hrvojka Bosnjak
Sime Spaventi
Kresimir Pavelic
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2011
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-10-22

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