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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 7/2008

01-07-2008 | Original Article

Colorectal cancer progression correlates with upregulation of S100A11 expression in tumor tissues

Authors: Guiyu Wang, Xishan Wang, Shuhuai Wang, Hongtao Song, Haiming Sun, Weiguang Yuan, Bo Cao, Jing Bai, Songbin Fu

Published in: International Journal of Colorectal Disease | Issue 7/2008

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Abstract

Background and aims

Early detection and treatment of human colorectal cancers remain a challenge. Identification of new potential markers may help in the diagnosis of colorectal cancer.

Materials and methods

By comparative two-dimensional gel electrophoresis using extracts from colorectal tumor and adjacent normal tissues, we identified a calcium-binding protein, S100A11, which was highly expressed in colorectal cancer compared with adjacent normal tissues. We expanded our study in 89 clinical colorectal tumor samples to validate this finding and correlates S100A11 expression in human colorectal cancer tissues with various stages of the tumor by Western blotting and immunohistochemical staining.

Results

We identified a calcium-binding protein, S100A11, which was highly expressed in colorectal cancer compared with adjacent normal tissues. S100A protein was expressed predominantly in the cytoplasm of normal tissue; however, it was expressed in both the nuclei and cytoplasm of colorectal cancer. S100A11 level in colorectal cancer tissue was increased following stage progression of the disease.

Conclusion

These findings suggest S100A11 could be helpful in the pathological study of colorectal cancer, especially for the classification of different stages in colorectal cancer.
Literature
1.
Arkenau HT, Chua YJ, Cunningham D (2007) Current treatment strategies in elderly patients with metastatic colorectal cancer. Clin Colorectal Cancer 7:508–515
2.
Smith FM, Gallagher WM, Fox E, Stephens RB, Rexhepaj E, Petricoin EF 3rd, Liotta L, Kennedy MJ, Reynolds JV (2007) Combination of SELDI-TOF-MS and data mining provides early-stage response prediction for rectal tumors undergoing multimodal neoadjuvant therapy. Ann Surg 245:259–266PubMedCrossRef
3.
Neal CP, Garcea G, Doucas H, Manson MM, Sutton CD, Dennison AR, Berry DP (2006) Molecular prognostic markers in resectable colorectal liver metastases: a systematic review. Eur J Cancer 42:1728–1743PubMedCrossRef
4.
Waterston AM, Cassidy J (2005) Adjuvant treatment strategies for early colon cancer. Drugs 65:1935–1947PubMedCrossRef
5.
de Noo ME, Tollenaar RA, Deelder AM, Bouwman LH (2006) Current status and prospects of clinical proteomics studies on detection of colorectal cancer: hopes and fears. World J Gastroenterol 12:6594–6601PubMed
6.
Widel MS, Widel M (2006) Mechanisms of metastasis and molecular markers of malignant tumor progression. I. Colorectal cancer. Postepy Hig Med Dosw (Online) 60:453–470
7.
Celen O, Kahraman I, Yildirim E, Berberoglu U (2004) Correlation of vascular endothelial growth factor (VEGF) and CEA with clinicopathological variables in colorectal cancer patients. Neoplasma 51:293–299PubMed
8.
Ahmed FE (2005) Molecular markers that predict response to colon cancer therapy. Expert Rev Mol Diagn 5:353–375PubMedCrossRef
9.
10.
Stulik J, Hernychova L, Porkertova S, Knizek J, Macela A, Bures J, Jandik P, Langridge JI, Jungblut PR (2001) Proteome study of colorectal carcinogenesis. Electrophoresis 22:019–3025CrossRef
11.
Stulik J, Koupilova K, Osterreicher J, Knizek J, Macela A, Bures J, Jandik P, Langr F, Dedic K, Jungblut PR (1999) Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma. Electrophoresis 20:3638–3646PubMedCrossRef
12.
Allen BG, Durussel I, Walsh MP, Cox JA (1996) Characterization of the Ca2+-binding properties of calgizzarin (S100C) isolated from chicken gizzard smooth muscle. Biochem Cell Biol 74:687–694PubMedCrossRef
13.
Watanabe M, Ando Y, Todoroki H, Minami H, Hidaka H (1991) Molecular cloning and sequencing of a cDNA clone encoding a new calcium binding protein, named calgizzarin, from rabbit lung. Biochem Biophys Res Commun 181:644–649PubMedCrossRef
14.
Todoroki H, Kobayashi R, Watanabe M, Minami H, Hidaka H (1991) Purification, characterization, and partial sequence analysis of a newly identified EF-hand type 13-kDa Ca(2+)-binding protein from smooth muscle and non-muscle tissues. J Biol Chem 266:18668–18673PubMed
15.
Naka M, Qing ZX, Sasaki T, Kise H, Tawara I, Hamaguchi S, Tanaka T (1994) Purification and characterization of a novel calcium-binding protein, S100C, from porcine heart. Biochim Biophys Acta 1223:348–353PubMedCrossRef
16.
Ohta H, Sasaki T, Naka M, Hiraoka O, Miyamoto C, Furuichi Y, Tanaka T (1991) Molecular cloning and expression of the cDNA coding for a new member of the S100 protein family from porcine cardiac muscle. FEBS Lett 295:93–96PubMedCrossRef
17.
Sakaguchi M, Miyazaki M, Inoue Y, Tsuji T, Kouchi H, Tanaka T, Yamada H, Namba M (2000) Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts. J Cell Biol 149:1193–1206PubMedCrossRef
18.
Sakaguchi M, Tsuji T, Inoue Y, Miyazaki M, Namba M, Yamada H, Tanaka T (2001) Loss of nuclear localization of the S100C protein in immortalized human fibroblasts. Radiat Res 155:208–214PubMedCrossRef
19.
Yao R, Davidson DD, Lopez-Beltran A, MacLennan GT, Montironi R, Cheng L (2007) The S100 proteins for screening and prognostic grading of bladder cancer. Histol Histopathol 22:1025–1032PubMed
20.
Sakaguchi M, Miyazaki M, Kondo T, Namba M (2001) Up-regulation of S100C in normal human fibroblasts in the process of aging in vitro. Exp Gerontol 36:1317–1325PubMedCrossRef
21.
22.
Kondo A, Sakaguchi M, Makino E, Namba M, Okada S, Huh NH (2002) Localization of S100C immunoreactivity in various human tissues. Acta Med Okayama 56:31–34PubMed
23.
Garrett SC, Varney KM, Weber DJ, Bresnick AR (2006) S100A4, a mediator of metastasis. J Biol Chem 281:677–680PubMedCrossRef
24.
Ilg EC, Schafer BW, Heizmann CW (1996) Expression pattern of S100 calcium-binding proteins in human tumors. Int J Cancer 68:325–332PubMedCrossRef
25.
Lof AL, Gustafsson G, Novak V, Engman L, Mikaelsson M (1992) Determination of total protein in highly purified factor IX concentrates. Vox Sang 63:172–177PubMed
26.
Van den Bergh G, Clerens S, Cnops L, Vandesande F, Arckens L (2003) Fluorescent two-dimensional difference gel electrophoresis and mass spectrometry identify age-related protein expression differences for the primary visual cortex of kitten and adult cat. J Neurochem 85:193–205PubMedCrossRef
27.
Yip MP, Tu SP, Chun A, Yasui Y, Taylor VM (2006) Participation in colorectal cancer screening among Chinese Americans. Asian Pac J Cancer Prev 7:645–650PubMed
28.
Robinson NA, Lapic S, Welter JF, Eckert RL (1997) S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. J Biol Chem 272:12035–12046PubMedCrossRef
29.
Bertagnolli MM (2007) Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back. Lancet Oncol 8:439–443PubMedCrossRef
30.
Wang XS, Wang K, Li X, Fu SB (2004) Effects of phosphorothioate anti-sense oligodeoxynucleotides on colorectal cancer cell growth and telomerase activity. World J Gastroenterol 10:3455–3458PubMed
31.
Torres-Cabala C, Bibbo M, Panizo-Santos A, Barazi H, Krutzsch H, Roberts DD, Merino MJ (2006) Proteomic identification of new biomarkers and application in thyroid cytology. Acta Cytol 50:518–528PubMed
32.
Tian T, Hao J, Xu A, Hao J, Luo C, Liu C, Huang L, Xiao X, He D (2007) Determination of metastasis-associated proteins in non-small cell lung cancer by comparative proteomic analysis. Cancer Sci 98(8):1265–1274PubMedCrossRef
33.
Song HY, Liu YK, Feng JT, Cui JF, Dai Z, Zhang LJ, Feng JX, Shen HL, Tang ZY (2006) Proteomic analysis on metastasis-associated proteins of human hepatocellular carcinoma tissues. J Cancer Res Clin Oncol 132:92–98PubMedCrossRef
34.
Memon AA, Sorensen BS, Meldgaard P, Fokdal L, Thykjaer T, Nexo E (2005) Down-regulation of S100C is associated with bladder cancer progression and poor survival. Clin Cancer Res 11:606–611PubMed
35.
Quirke P, Williams GT, Ectors N, Ensari A, Piard F, Nagtegaal I (2007) The future of the TNM staging system in colorectal cancer: time for a debate? Lancet Oncol 8:651–657PubMedCrossRef
36.
Lee SH (2006) TNM staging, molecular staging and prognostic factors of rectal cancer. Korean J Gastroenterol 47:291–294PubMed
37.
Horton JK, Tepper JE (2005) Staging of colorectal cancer: past, present, and future. Clin Colorectal Cancer 4:302–312PubMedCrossRef
38.
Compton CC, Fielding LP, Burgart LJ, Conley B, Cooper HS, Hamilton SR, Hammond ME, Henson DE, Hutter RV, Nagle RB, Nielsen ML, Sargent DJ, Taylor CR, Welton M, Willett C (2000) Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 124:979–994PubMed
39.
Booth RA (2007) Minimally invasive biomarkers for detection and staging of colorectal cancer. Cancer Lett 249:87–96PubMedCrossRef
40.
Karantanas AH, Yarmenitis S, Papanikolaou N, Gourtsoyiannis N (2007) Preoperative imaging staging of rectal cancer. Dig Dis 25:20–32PubMedCrossRef
41.
Komatsu Y (2007) Adjuvant chemotherapy for colorectal cancer in Japan-current state and problem areas. Gan To Kagaku Ryoho 34:799–807PubMed
42.
Daniels IR, Fisher SE, Heald RJ, Moran BJ (2007) Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence. Colorectal Dis 9:290–301PubMedCrossRef
43.
Inada H, Naka M, Tanaka T, Davey GE, Heizmann CW (1999) Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization. Biochem Biophys Res Commun 263:135–138PubMedCrossRef
Metadata
Title
Colorectal cancer progression correlates with upregulation of S100A11 expression in tumor tissues
Authors
Guiyu Wang
Xishan Wang
Shuhuai Wang
Hongtao Song
Haiming Sun
Weiguang Yuan
Bo Cao
Jing Bai
Songbin Fu
Publication date
01-07-2008
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 7/2008
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-008-0464-6

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