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Molecular Cancer
Published in: Molecular Cancer 1/2011

Open Access 01-12-2011 | Review

Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin

Authors: Ronan J Kelly, Ariel Lopez-Chavez, Deborah Citrin, John E Janik, John C Morris

Published in: Molecular Cancer | Issue 1/2011

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Abstract

Survivin (BIRC5), a member of the inhibitor of apoptosis protein (IAP) family that inhibits caspases and blocks cell death is highly expressed in cancer and is associated with a poorer clinical outcome. Functioning simultaneously during cell division and apoptosis inhibition, survivin plays a pivotal role in determining cell survival. Survivin has consistently been identified by molecular profiling analysis to be associated with higher tumor grade, more advanced disease, abbreviated survival, accelerated rates of recurrence, and chemotherapy and radiation resistance. Survivin's differential expression in cancer compared to normal tissue and its role as a nodal protein in a number of cellular pathways make it a highly flexible therapeutic target, suitable for small-molecule inhibitiors, molecular antagonists, and vaccination-based therapies. By targeting survivin it is hoped that multiple tumor signaling circuitries may be simultaneously disabled. This effect may be applicable to many tumor histologies irrespective of specific genetic makeup. To date, survivin inhibitors have shown modest activity as single agents, but it is anticipated that when given in combination with cytotoxic chemotherapy or monoclonal antibodies they may exhibit enhanced efficacy. This review discusses the complex circuitry of survivin in human cancers and highlights clinical trials involving novel agents that target this important protein.
Appendix
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Metadata
Title
Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin
Authors
Ronan J Kelly
Ariel Lopez-Chavez
Deborah Citrin
John E Janik
John C Morris
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2011
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-10-35

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