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Respiratory Research
Published in: Respiratory Research 1/2013

Open Access 01-12-2013 | Review

Infection, inflammation and exercise in cystic fibrosis

Authors: Pauline Barbera van de Weert-van Leeuwen, Hubertus Gerardus Maria Arets, Cornelis Korstiaan van der Ent, Jeffrey Matthijn Beekman

Published in: Respiratory Research | Issue 1/2013

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Abstract

Regular exercise is positively associated with health. It has also been suggested to exert anti-inflammatory effects. In healthy subjects, a single exercise session results in immune cell activation, which is characterized by production of immune modulatory peptides (e.g. IL-6, IL-8), a leukocytosis and enhanced immune cell functions. Upon cessation of exercise, immune activation is followed by a tolerizing phase, characterized by a reduced responsiveness of immune cells. Regular exercise of moderate intensity and duration has been shown to exert anti-inflammatory effects and is associated with a reduced disease incidence and viral infection susceptibility. Specific exercise programs may therefore be used to modify the course of chronic inflammatory and infectious diseases such as cystic fibrosis (CF).
Patients with CF suffer from severe and chronic pulmonary infections and inflammation, leading to obstructive and restrictive pulmonary disease, exercise intolerance and muscle cachexia. Inflammation is characterized by a hyper-inflammatory phenotype. Patients are encouraged to engage in exercise programs to maintain physical fitness, quality of life, pulmonary function and health.
In this review, we present an overview of available literature describing the association between regular exercise, inflammation and infection susceptibility and discuss the implications of these observations for prevention and treatment of inflammation and infection susceptibility in patients with CF.
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Metadata
Title
Infection, inflammation and exercise in cystic fibrosis
Authors
Pauline Barbera van de Weert-van Leeuwen
Hubertus Gerardus Maria Arets
Cornelis Korstiaan van der Ent
Jeffrey Matthijn Beekman
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2013
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-14-32

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