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Molecular Cancer
Published in: Molecular Cancer 1/2020

Open Access 01-12-2020 | Kidney Cancer | Review

Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy

Authors: Ying Wang, Yunjing Zhang, Ping Wang, Xianghui Fu, Weiqiang Lin

Published in: Molecular Cancer | Issue 1/2020

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Abstract

Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. Circular RNAs (circRNAs) are noncoding RNAs with widespread distribution and diverse cellular functions. They are highly stable and have organ- and tissue-specific expression patterns. CircRNAs have essential functions as microRNA sponges, RNA-binding protein- and transcriptional regulators, and protein translation templates. Recent reports have shown that circRNAs are abnormally expressed in RCC and act as important regulators of RCC carcinogenesis and progression. Moreover, circRNAs have emerged as potential biomarkers for RCC diagnosis and prognosis and targets for developing new treatments. However, further studies are needed to better understand the functions of circRNAs in RCC. In this review, we summarize and discuss the recent research progress on RCC-associated circRNAs, with a focus on their potential for RCC diagnosis and targeted therapy.
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Metadata
Title
Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy
Authors
Ying Wang
Yunjing Zhang
Ping Wang
Xianghui Fu
Weiqiang Lin
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2020
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-020-01266-7

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