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Molecular Cancer

Issue 1/2020

Content (174 Articles)

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Xin Li, Chuanyun Li, Liping Zhang, Min Wu, Ke Cao, Feifei Jiang, Dexi Chen, Ning Li, Weihua Li

The emerging role of SPOP protein in tumorigenesis and cancer therapy

Yizuo Song, Yichi Xu, Chunyu Pan, Linzhi Yan, Zhi-wei Wang, Xueqiong Zhu

RETRACTED ARTICLE: m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

Bo Tang, Yihua Yang, Min Kang, Yunshan Wang, Yan Wang, Yin Bi, Songqing He, Fumio Shimamoto

A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma

Hailong Ma, Hanyue Chang, Wenyi Yang, Yusheng Lu, Jingzhou Hu, Shufang Jin

Role of HDACs in normal and malignant hematopoiesis

Pan Wang, Zi Wang, Jing Liu

TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL2

You Shuai, Zhonghua Ma, Weitao Liu, Tao Yu, Changsheng Yan, Hua Jiang, Shengwang Tian, Tongpeng Xu, Yongqian Shu

Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

Sandra Muñoz-Galván, Blanca Felipe-Abrio, Eva M. Verdugo-Sivianes, Marco Perez, Manuel P. Jiménez-García, Elisa Suarez-Martinez, Purificacion Estevez-Garcia, Amancio Carnero

Circular RNAs in the tumour microenvironment

Zhonghua Ma, You Shuai, Xiangyu Gao, Xianzi Wen, Jiafu Ji

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

Jinchang Pan, Shuai Fang, Haihua Tian, Chengwei Zhou, Xiaodong Zhao, Hui Tian, Jinxian He, Weiyu Shen, Xiaodan Meng, Xiaofeng Jin, Zhaohui Gong

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer

Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, Zhe-Sheng Chen

Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response

Lin Huan, Tianan Guo, Yangjun Wu, Linguo Xu, Shenglin Huang, Ye Xu, Linhui Liang, Xianghuo He

Autophagy and autophagy-related proteins in cancer

Xiaohua Li, Shikun He, Binyun Ma

CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer

Hongbao Yang, Xiaobo Li, Qingtao Meng, Hao Sun, Shenshen Wu, Weiwei Hu, Guilai Liu, Xianjing Li, Yong Yang, Rui Chen

Roles of circRNAs in the tumour microenvironment

Qiuge Zhang, Weiwei Wang, Quanbo Zhou, Chen Chen, Weitang Yuan, Jinbo Liu, Xiaoli Li, Zhenqiang Sun

Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy

Xiaoming Zhong, Hangtian Zhang, Ying Zhu, Yuqing Liang, Zhuolin Yuan, Jiachen Li, Jing Li, Xin Li, Yifan Jia, Tian He, Jiangyuan Zhu, Yu Sun, Wengting Jiang, Hui Zhang, Cheng Wang, Zunfu Ke

Correction to: Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Correction

Martin P. Barr, Steven G. Gray, Kathy Gately, Emily Hams, Padraic G. Fallon, Anthony Mitchell Davies, Derek J. Richard, Graham P. Pidgeon, Kenneth J. O’Byrne

Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

Jiehua He, Zuoyu Huang, Mingliang He, Jianyou Liao, Qianqian Zhang, Shengwen Wang, Lin Xie, Leping Ouyang, H. Phillip Koeffler, Dong Yin, Anmin Liu

Long non-coding RNA UCA1 promotes malignant phenotypes of renal cancer cells by modulating the miR-182-5p/DLL4 axis as a ceRNA

Wei Wang, Wentao Hu, Ya Wang, Yong An, Lei Song, Panfeng Shang, Zhongjin Yue

Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Daixi Ren, Yuze Hua, Boyao Yu, Xin Ye, Ziheng He, Chunwei Li, Jie Wang, Yongzhen Mo, Xiaoxu Wei, Yunhua Chen, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Zhaoyang Zeng, Wei Xiong

Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340

Xiangyu Jian, Han He, Jiehong Zhu, Qi Zhang, Zhongxin Zheng, Xiangjing Liang, Liuyan Chen, Meiling Yang, Kaiyue Peng, Zhaowen Zhang, Tengfei Liu, Yaping Ye, Hongli Jiao, Shuyang Wang, Weijie Zhou, Yanqing Ding, Tingting Li

Correction to: Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells

  • Open Access
  • NSCLC
  • Correction

Peng-Fei Zhang, Xu Pei, Ke-Sang Li, Li-Na Jin, Fei Wang, Jing Wu, Xue-Mei Zhang

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

  • Open Access
  • Review

Pan Wu, Yongzhen Mo, Miao Peng, Ting Tang, Yu Zhong, Xiangying Deng, Fang Xiong, Can Guo, Xu Wu, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong

circRIP2 accelerates bladder cancer progression via miR-1305/Tgf-β2/smad3 pathway

Yinjie Su, Weilian Feng, Juanyi Shi, Luping Chen, Jian Huang, Tianxin Lin

Correction to: m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma

  • Open Access
  • Correction

Li Liu, Jing Wang, Guifeng Sun, Qiong Wu, Ji Ma, Xin Zhang, Nan Huang, Zhixuan Bian, Song Gu, Min Xu, Minzhi Yin, Fenyong Sun, Qiuhui Pan

Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2

Yonghao Zhan, Zhicong Chen, Shiming He, Yanqing Gong, Anbang He, Yifan Li, Lianghao Zhang, Xuepei Zhang, Dong Fang, Xuesong Li, Liqun Zhou

RETRACTED ARTICLE: Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation

Mingli Han, Yuanting Gu, Pengwei Lu, Jingyi Li, Hui Cao, Xiangke Li, Xueke Qian, Chao Yu, Yunqing Yang, Xue Yang, Na Han, Dongwei Dou, Jianguo Hu, Huaying Dong

Crosstalk between autophagy and metabolic regulation of cancer stem cells

Mouradi El Hout, Emma Cosialls, Maryam Mehrpour, Ahmed Hamaï

DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma

Chenfei Lu, Yutian Wei, Xiefeng Wang, Zhuoran Zhang, Jianxing Yin, Wentao Li, Lijiu Chen, Xiao Lyu, Zhumei Shi, Wei Yan, Yongping You

microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

Ranjana K. Kanchan, Jawed A. Siddiqui, Sidharth Mahapatra, Surinder K. Batra, Mohd W. Nasser

Translation and functional roles of circular RNAs in human cancer

Ming Lei, Guantao Zheng, Qianqian Ning, Junnian Zheng, Dong Dong

Correction to: Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Daixi Ren, Yuze Hua, Boyao Yu, Xin Ye, Ziheng He, Chunwei Li, Jie Wang, Yongzhen Mo, Xiaoxu Wei, Yunhua Chen, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Zhaoyang Zeng, Wei Xiong

Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma

Jia-qiao Fan, Meng-Fei Wang, Hai-Long Chen, Dong Shang, Jugal K. Das, Jianxun Song

Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1

Xiaohong Hong, Na Liu, Yelin Liang, Qingmei He, Xiaojing Yang, Yuan Lei, Panpan Zhang, Yin Zhao, Shiwei He, Yaqin Wang, Junyan Li, Qian Li, Jun Ma, Yingqin Li

Functions and clinical significance of circular RNAs in glioma

Jikui Sun, Banban Li, Chang Shu, Quanfeng Ma, Jinhuan Wang

lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer

  • Open Access
  • Research

Xiaofan Ren, Changhao Chen, Yuming Luo, Mingyang Liu, Yuting Li, Shangyou Zheng, Huilin Ye, Zhiqiang Fu, Min Li, Zhihua Li, Rufu Chen

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Joséphine Briand, Farida Akcha, Dominique Heymann, François M. Vallette, Jean Mosser, Benjamin Ory, Pierre-François Cartron

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

Ramesh Pothuraju, Satyanarayana Rachagani, Shiv Ram Krishn, Sanjib Chaudhary, Rama Krishna Nimmakayala, Jawed A. Siddiqui, Koelina Ganguly, Imayavaramban Lakshmanan, Jesse L. Cox, Kavita Mallya, Sukhwinder Kaur, Surinder K. Batra

mRNA modification orchestrates cancer stem cell fate decisions

  • Open Access
  • Review

Weicheng Liang, Zexiao Lin, Cong Du, Dongbo Qiu, Qi Zhang

The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

Yuqing Wu, Siwei Zhang, Xiaoxiao Gong, Samantha Tam, Desheng Xiao, Shuang Liu, Yongguang Tao

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

  • Open Access
  • NSCLC
  • Research

Dan Jin, Jiwei Guo, Yan Wu, Lijuan Yang, Xiaohong Wang, Jing Du, Juanjuan Dai, Weiwei Chen, Kaikai Gong, Shuang Miao, Xuelin Li, Hongliang Sun

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

  • Open Access
  • Research

Hui Yang, Qiannan Zhang, Miao Xu, Lei Wang, Xuewei Chen, Yongquan Feng, Yongning Li, Xin Zhang, Wenming Cui, Xudong Jia

Characterization of novel LncRNA P14AS as a protector of ANRIL through AUF1 binding in human cells

Wanru Ma, Juanli Qiao, Jing Zhou, Liankun Gu, Dajun Deng

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

Haiyang Zhang, Ting Deng, Rui Liu, Tao Ning, Haiou Yang, Dongying Liu, Qiumo Zhang, Dan Lin, Shaohua Ge, Ming Bai, Xinyi Wang, Le Zhang, Hongli Li, Yuchong Yang, Zhi Ji, Hailong Wang, Guoguang Ying, Yi Ba

The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis

Mengnuo Chen, Chun-Ming Wong

CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a

Xiaoling Gan, Hongtao Zhu, Xingwei Jiang, Samuel C. Obiegbusi, Min Yong, Xingtao Long, Jianguo Hu

METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

Xiao Yang, Sen Zhang, Changyu He, Pei Xue, Luyang Zhang, Zirui He, Lu Zang, Bo Feng, Jing Sun, Minhua Zheng

Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

Xinyi Zhang, Kai Xie, Honghua Zhou, Yuwei Wu, Chan Li, Yating Liu, Zhaoya Liu, Qian Xu, Shuang Liu, Desheng Xiao, Yongguang Tao

Noncoding RNAs in cancer immunity: functions, regulatory mechanisms, and clinical application

  • Open Access
  • Review

Le Zhang, Xiaonan Xu, Xiulan Su

PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications

Heng Zhu, Miaoyan Wei, Jin Xu, Jie Hua, Chen Liang, Qingcai Meng, Yiyin Zhang, Jiang Liu, Bo Zhang, Xianjun Yu, Si Shi

Metabolism of pancreatic cancer: paving the way to better anticancer strategies

Cheng Qin, Gang Yang, Jinshou Yang, Bo Ren, Huanyu Wang, Guangyu Chen, Fangyu Zhao, Lei You, Weibin Wang, Yupei Zhao

MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer

Juan Xu, Tingting Shao, Mingxu Song, Yunjin Xie, Jialiang Zhou, Jiaqi Yin, Na Ding, Haozhe Zou, Yongsheng Li, Jiwei Zhang

Verification of EZH2 as a druggable target in metastatic uveal melanoma

Bei Jin, Ping Zhang, Hailin Zou, Huijing Ye, Yun Wang, Jing Zhang, Huasheng Yang, Jingxuan Pan

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Bo Zhang, Qiong Wu, Ben Li, Defeng Wang, Lei Wang, You Lang Zhou

Long non-coding RNAs regulate drug resistance in cancer

Kaisheng Liu, Lin Gao, Xiaoshi Ma, Juan-Juan Huang, Juan Chen, Leli Zeng, Charles R. Ashby Jr., Chang Zou, Zhe-Sheng Chen

Correction to: Role of HDACs in normal and malignant hematopoiesis

Pan Wang, Zi Wang, Jing Liu

CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification

Mengmeng Jie, Yaran Wu, Mengyuan Gao, Xinzhe Li, Cheng Liu, Qin Ouyang, Qingyun Tang, Changyu Shan, Yangfan Lv, Kebin Zhang, Qian Dai, Yang Chen, Shuo Zeng, Chenglin Li, Liting Wang, Fengtian He, Changjiang Hu, Shiming Yang

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Ajaz A. Bhat, Salma N. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Santosh K. Yadav, Wael El-Rifai, Mohammad A. Zargar, Hatem Zayed, Mohammad Haris, Shahab Uddin

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

Chaochu Cui, Jianbo Yang, Xiao Li, Dongling Liu, Liwu Fu, Xianwei Wang

Correction to: Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth

  • Open Access
  • Correction

Liang-qi Cao, Xue-wei Yang, Yu-bin Chen, Da-wei Zhang, Xiao-Feng Jiang, Ping Xue

CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17

Kai Han, Feng-Wei Wang, Chen-Hui Cao, Han Ling, Jie-Wei Chen, Ri-Xin Chen, Zi-Hao Feng, Jie Luo, Xiao-Han Jin, Jin-Ling Duan, Shu-Man Li, Ning-Fang Ma, Jing-Ping Yun, Xin-Yuan Guan, Zhi-Zhong Pan, Ping Lan, Rui-Hua Xu, Dan Xie

The network of non-coding RNAs and their molecular targets in breast cancer

Francesca Crudele, Nicoletta Bianchi, Eva Reali, Marco Galasso, Chiara Agnoletto, Stefano Volinia

Noncoding RNAs in gastric cancer: implications for drug resistance

Ling Wei, Jujie Sun, Nasha Zhang, Yan Zheng, Xingwu Wang, Liyan Lv, Jiandong Liu, Yeyang Xu, Yue Shen, Ming Yang

microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation

Maureen Labbé, Christianne Hoey, Jessica Ray, Vincent Potiron, Stéphane Supiot, Stanley K. Liu, Delphine Fradin

Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology

Xiao Yang, Ming Liu, Mengmeng Li, Sen Zhang, Hong Hiju, Jing Sun, Zhihai Mao, Minhua Zheng, Bo Feng

Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression

Gehao Liang, Yun Ling, Maryam Mehrpour, Phei Er Saw, Zihao Liu, Weige Tan, Zhenluan Tian, Wenjing Zhong, Wanyi Lin, Qing Luo, Qun Lin, Qiufang Li, You Zhou, Ahmed Hamai, Patrice Codogno, Jun Li, Erwei Song, Chang Gong

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

Jian Cheng, Jinli Meng, Lei Zhu, Yong Peng

Correction to: Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/Vimentin axis

  • Open Access
  • Correction

Zhonglin Zhu, Zeyin Rong, Zai Luo, Zhilong Yu, Jing Zhang, Zhengjun Qiu, Chen Huang

Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

Ming-jie Jiang, Yi-yun Chen, Juan-juan Dai, Dian-na Gu, Zhu Mei, Fu-rao Liu, Qian Huang, Ling Tian

Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin

Martina Ghetti, Ivan Vannini, Clelia Tiziana Storlazzi, Giovanni Martinelli, Giorgia Simonetti

Disruption of the RNA modifications that target the ribosome translation machinery in human cancer

  • Open Access
  • Review

Maxime Janin, Laia Coll-SanMartin, Manel Esteller

A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer

Zihao Pan, Jianye Cai, Jiatong Lin, Huinian Zhou, Jingwen Peng, Jinliang Liang, Long Xia, Qi Yin, Baojia Zou, Jun Zheng, Liang Qiao, Lei Zhang

m6A-dependent glycolysis enhances colorectal cancer progression

Chaoqin Shen, Baoqin Xuan, Tingting Yan, Yanru Ma, Pingping Xu, Xianglong Tian, Xinyu Zhang, Yingying Cao, Dan Ma, Xiaoqiang Zhu, Youwei Zhang, Jing-Yuan Fang, Haoyan Chen, Jie Hong

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer

Xiaying Zheng, Mengge Huang, Lei Xing, Rui Yang, Xiaosong Wang, Rong Jiang, Luyu Zhang, Junxia Chen

Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis

  • Open Access
  • Review

Yuan Tan, Yuejin Li, Faqing Tang

Correction to: CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen, Xiangqian Fang

RNA-seq reveals novel CircRNAs involved in breast cancer progression and patient therapy response

Christophe Nicot

The role of long noncoding RNAs in hepatocellular carcinoma

Zhao Huang, Jian-Kang Zhou, Yong Peng, Weifeng He, Canhua Huang

Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation

  • Open Access
  • Review

Hanhan Shi, Peiwei Chai, Renbing Jia, Xianqun Fan

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Sha Li, Ning Wang, Yibin Feng

Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection

Qi Kong, Zhiguang Xiang, Yue Wu, Yu Gu, Jianguo Guo, Fei Geng

The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy

Xueping Wang, Fang Wang, Mengjun Zhong, Yosef Yarden, Liwu Fu

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Yao Kong, Yuting Li, Yuming Luo, Jiang Zhu, Hanhao Zheng, Bowen Gao, Xiaofeng Guo, Zhihua Li, Rufu Chen, Changhao Chen

Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis

  • Open Access
  • Research

Xiaofeng Guo, Quanbo Zhou, Dan Su, Yuming Luo, Zhiqiang Fu, Leyi Huang, Zhiguo Li, Decan Jiang, Yao Kong, Zhihua Li, Rufu Chen, Changhao Chen

Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma

Chuan-Yuan Wei, Meng-Xuan Zhu, Nan-Hang Lu, Jia-Qi Liu, Yan-Wen Yang, Yong Zhang, Yue-Dong Shi, Zi-Hao Feng, Jia-Xia Li, Fa-Zhi Qi, Jian-Ying Gu

RETRACTED ARTICLE: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis

Yiran Liang, Xiaojin Song, Yaming Li, Bing Chen, Wenjing Zhao, Lijuan Wang, Hanwen Zhang, Ying Liu, Dianwen Han, Ning Zhang, Tingting Ma, Yajie Wang, Fangzhou Ye, Dan Luo, Xiaoyan Li, Qifeng Yang

Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression

Zai Luo, Zeyin Rong, Jianming Zhang, Zhonglin Zhu, Zhilong Yu, Tengfei Li, Zhongmao Fu, Zhengjun Qiu, Chen Huang

LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer

Xi Jin, Li-Ping Ge, Da-Qiang Li, Zhi-Ming Shao, Gen-Hong Di, Xiao-En Xu, Yi-Zhou Jiang

The potential role of RNA N6-methyladenosine in Cancer progression

  • Open Access
  • Review

Tianyi Wang, Shan Kong, Mei Tao, Shaoqing Ju

Correction to: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

  • Open Access
  • Correction

Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun, Chuanxin Wang

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

  • Open Access
  • NSCLC
  • Research

Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Xingya Guo, Kai Li, Weiliang Jiang, Yangyang Hu, Wenqin Xiao, Yinshi Huang, Yun Feng, Qin Pan, Rong Wan

Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

Xiao-Yong Huang, Peng-Fei Zhang, Chuan-Yuan Wei, Rui Peng, Jia-Cheng Lu, Chao Gao, Jia-Bing Cai, Xuan Yang, Jia Fan, Ai-Wu Ke, Jian Zhou, Guo-Ming Shi

Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy

Ke Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran, Xingming Deng

Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer

Yi Chen, Yu Lin, Yongqian Shu, Jing He, Wen Gao

Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2′-O-methylation via NOP58 recruitment in colorectal cancer

Huizhe Wu, Wenyan Qin, Senxu Lu, Xiufang Wang, Jing Zhang, Tong Sun, Xiaoyun Hu, Yalun Li, Qiuchen Chen, Yuanhe Wang, Haishan Zhao, Haiyan Piao, Rui Zhang, Minjie Wei

Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance

Li Yuan, Zhi-Yuan Xu, Shan-Ming Ruan, Shaowei Mo, Jiang-Jiang Qin, Xiang-Dong Cheng

Correction to: Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating acrophages with alteration of the TIMP-1/MMP2/MMP9 signals

  • Open Access
  • Correction

Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li, Chawnshang Chang

LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression

Jiarong Chen, Aibin Liu, Zhihui Wang, Bin Wang, Xingxing Chai, Wenjie Lu, Ting Cao, Ronggang Li, Minyan Wu, Zhuming Lu, Wenguang Pang, Lin Xiao, Xiangmeng Chen, Yan Zheng, Qiong Chen, Jincheng Zeng, Jun Li, Xin Zhang, Dong Ren, Yanming Huang

Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis

Yongyan Wu, Yuliang Zhang, Xiwang Zheng, Fengsheng Dai, Yan Lu, Li Dai, Min Niu, Huina Guo, Wenqi Li, Xuting Xue, Yunfeng Bo, Yujia Guo, Jiangbo Qin, Yixiao Qin, Hongliang Liu, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Huizheng Li, Wei Xu, Wei Gao

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review

Wei Feng, Wei Zong, Feng Wang, Shaoqing Ju

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

  • Open Access
  • NSCLC
  • Research

Nan Zhang, Aruo Nan, Lijian Chen, Xin Li, Yangyang Jia, Miaoyun Qiu, Xin Dai, Hanyu Zhou, Jialu Zhu, Han Zhang, Yiguo Jiang

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

Wei Hu, Cong Liu, Zhuo-Yue Bi, Qun Zhou, Han Zhang, Lin-Lin Li, Jian Zhang, Wei Zhu, Yang-Yi-Yan Song, Feng Zhang, Hui-Min Yang, Yong-Yi Bi, Qi-Qiang He, Gong-Jun Tan, Cheng-Cao Sun, De-Jia Li

RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

Jianfa Li, Chenchen Huang, Yifan Zou, Jing Ye, Jing Yu, Yaoting Gui

Mechanism of RNA modification N6-methyladenosine in human cancer

Zijian Zhou, Jiancheng Lv, Hao Yu, Jie Han, Xiao Yang, Dexiang Feng, Qikai Wu, Baorui Yuan, Qiang Lu, Haiwei Yang

The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs

  • Open Access
  • Review

Lele Zhang, Chaofeng Hou, Chen Chen, Yaxin Guo, Weitang Yuan, Detao Yin, Jinbo Liu, Zhenqiang Sun

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

Xiaoxiang Chen, Mu Xu, Xueni Xu, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Chenmeng Li, Li Sun, Jian Qin, Tao Xu, Bangshun He, Yuqin Pan, Huilin Sun, Shukui Wang

PARP inhibitor resistance: the underlying mechanisms and clinical implications

He Li, Zhao-Yi Liu, Nayiyuan Wu, Yong-Chang Chen, Quan Cheng, Jing Wang

The genetic and pharmacogenomic landscape of snoRNAs in human cancer

  • Open Access
  • Letter to the Editor

Yaoming Liu, Hang Ruan, Shengli Li, Youqiong Ye, Wei Hong, Jing Gong, Zhao Zhang, Ying Jing, Xiulan Zhang, Lixia Diao, Leng Han

Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer

Yaqing Li, Zhenfeng Tian, Ying Tan, Guoda Lian, Shangxiang Chen, Shaojie Chen, Jiajia Li, Xuanna Li, Kaihong Huang, Yinting Chen

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Peng-Fei Zhang, Chao Gao, Xiao-Yong Huang, Jia-Cheng Lu, Xiao-Jun Guo, Guo-Ming Shi, Jia-Bin Cai, Ai-Wu Ke

Correction to: microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11

Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan, Jian-Ru Xiao

Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation

Mengyan Xie, Tao Yu, Xinming Jing, Ling Ma, Yu Fan, Fengming Yang, Pei Ma, Huning Jiang, Xi Wu, Yongqian Shu, Tongpeng Xu

Correction to: Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis

  • Open Access
  • Correction

Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang, Baosheng Li

m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling

Jian-Wei Xie, Xiao-Bo Huang, Qi-Yue Chen, Yu-Bin Ma, Ya-Jun Zhao, Li-Chao Liu, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Chang-Ming Huang, Ping Li

A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3

Xiaoyu He, Peiwei Chai, Fang Li, Leilei Zhang, Chuandi Zhou, Xiaoling Yuan, Yongyun Li, Jie Yang, Yingxiu Luo, Shengfang Ge, He Zhang, Renbing Jia, Xianqun Fan

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

  • Open Access
  • Review

Chunxiao Li, Ping Jiang, Shuhua Wei, Xiaofei Xu, Junjie Wang

Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis

Anquan Shang, Chenzheng Gu, Weiwei Wang, Xuan Wang, Junjun Sun, Bingjie Zeng, Chen Chen, Wenjing Chang, Yili Ping, Ping Ji, Junlu Wu, Wenqiang Quan, Yiwen Yao, Yongxin Zhou, Zujun Sun, Dong Li

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

Cefan Zhou, Changhua Yi, Yongxiang Yi, Wenying Qin, Yanan Yan, Xueying Dong, Xuewen Zhang, Yuan Huang, Rui Zhang, Jie Wei, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Jingfeng Tang

CircRNAs: biogenesis, functions, and role in drug-resistant Tumours

  • Open Access
  • Review

Shuo Ma, Shan Kong, Feng Wang, Shaoqing Ju

Natural killer cells in cancer biology and therapy

  • Open Access
  • Review

Song-Yang Wu, Tong Fu, Yi-Zhou Jiang, Zhi-Ming Shao

Novel insights into the interplay between m6A modification and noncoding RNAs in cancer

  • Open Access
  • NSCLC
  • Review

You-Cai Yi, Xiao-Yu Chen, Jing Zhang, Jin-Shui Zhu

Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

Rong Deng, Jun-Hao Huang, Yan Wang, Li-Huan Zhou, Zi-Feng Wang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Jia Mai, Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Xiao-Dan Peng, Gong-Kan Feng, Xiao-Feng Zhu, Jun Tang

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1

Yunhao Chen, Yanchun Zhao, Junru Chen, Chuanhui Peng, Yanpeng Zhang, Rongliang Tong, Qiyang Cheng, Beng Yang, Xiaode Feng, Yuejie Lu, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng

Correction to: Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis

  • Open Access
  • Correction

Hongwei Liu, Junming Bi, Wei Dong, Meihua Yang, Juanyi Shi, Ning Jiang, Tianxin Lin, Jian Huang

Correction to: CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling

Jing Zhang, Lidan Hou, Rui Liang, Xiaoyu Chen, Rui Zhang, Wei Chen, Jinshui Zhu

Retraction Note: HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells

  • Open Access
  • Retraction Note

Paola Bendinelli, Paola Maroni, Emanuela Matteucci, Maria Alfonsina Desiderio

CircRNAs in anticancer drug resistance: recent advances and future potential

Tianwei Xu, Mengwei Wang, Lihua Jiang, Li Ma, Li Wan, Qinnan Chen, Chenchen Wei, Zhaoxia Wang

CircRNA inhibits DNA damage repair by interacting with host gene

Xiaolong Xu, Jingwei Zhang, Yihao Tian, Yang Gao, Xin Dong, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Ke Chen, Chunjiang He, Lei Wei

β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer

Ping Song, Lifeng Feng, Jiaqiu Li, Dongjun Dai, Liyuan Zhu, Chaoqun Wang, Jingyi Li, Ling Li, Qiyin Zhou, Rongkai Shi, Xian Wang, Hongchuan Jin

Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

Min Wang, Jun Liu, Yan Zhao, Ruizhi He, Xiaodong Xu, Xingjun Guo, Xu Li, Simiao Xu, Ji Miao, Jianpin Guo, Hang Zhang, Jun Gong, Feng Zhu, Rui Tian, Chengjian Shi, Feng Peng, Yechen Feng, Shuo Yu, Yu Xie, Jianxin Jiang, Min Li, Wenyi Wei, Chuan He, Renyi Qin

Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer

Mitsuro Kanda, Dai Shimizu, Koichi Sawaki, Shunsuke Nakamura, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Chie Tanaka, Masamichi Hayashi, Yohei Iguchi, Suguru Yamada, Masahisa Katsuno, Yasuhiro Kodera

The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

Abakundana Nsenga Ariston Gabriel, Fang Wang, Qinlian Jiao, Umwali Yvette, Xuemei Yang, Samed Ahmed Al-Ameri, Lutao Du, Yun-shan Wang, Chuanxin Wang

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Juyan Zheng, Junluan Mo, Tao Zhu, Wei Zhuo, Yueneng Yi, Shuo Hu, Jiye Yin, Wei Zhang, Honghao Zhou, Zhaoqian Liu

Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Wenjing Wang, Mengyue Zhao, Lijuan Cui, Yong Ren, Jingyuan Zhang, Junli Chen, Lina Jia, Jiayu Zhang, Jingyu Yang, Guoliang Chen, Charles R. Ashby Jr, Chunfu Wu, Zhe-Sheng Chen, Lihui Wang

The potential roles of exosomes in pancreatic cancer initiation and metastasis

Wei Sun, Ying Ren, Zaiming Lu, Xiangxuan Zhao

cGAS-STING pathway in cancer biotherapy

Yang Wang, Jingwen Luo, Aqu Alu, Xuejiao Han, Yuquan Wei, Xiawei Wei

Correction to: YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma

Jiajie Hou, He Zhang, Jun Liu, Zhenjun Zhao, Jianye Wang, Zhike Lu, Bian Hu, Jiankui Zhou, Zhicong Zhao, Mingxuan Feng, Haiyan Zhang, Bin Shen, Xingxu Huang, Beicheng Sun, Mark J. Smyth, Chuan He, Qiang Xia

Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

Jiacheng Lou, Yuchao Hao, Kefeng Lin, Yizhu Lyu, Meiwei Chen, Han Wang, Deyu Zou, Xuewen Jiang, Renchun Wang, Di Jin, Eric W.-F. Lam, Shujuan Shao, Quentin Liu, Jinsong Yan, Xiang Wang, Puxiang Chen, Bo Zhang, Bilian Jin

Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells

Chien-Hung Yeh, Marcia Bellon, Fang Wang, Hong Zhang, Liwu Fu, Christophe Nicot

Correction to: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p

  • Open Access
  • Correction

Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang, Hongyong Cao

Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook

  • Open Access
  • NSCLC
  • Review

Lena Horvath, Bernard Thienpont, Liyun Zhao, Dominik Wolf, Andreas Pircher

Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab

Jie Li, Maoguang Ma, Xuesong Yang, Maolei Zhang, Jingyan Luo, Huangkai Zhou, Nunu Huang, Feizhe Xiao, Bingquan Lai, Weiming Lv, Nu Zhang

Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA

Min Kang, Bo Tang, Jixi Li, Ziyan Zhou, Kang Liu, Rensheng Wang, Ziyan Jiang, Fangfang Bi, David Patrick, Dongin Kim, Anirban K. Mitra, Yang Yang-Hartwich

Correction to: CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p

Lu Wang, Guang Yang, Danfeng Zhao, Jiaqi Wang, Yang Bai, Qiang Peng, Hongzhi Wang, Ruizhe Fang, Guang Chen, Zhichao Wang, Keliang Wang, Guangbin Li, Yinhui Yang, Ziqi Wang, Pengyu Guo, Li Peng, Dayong Hou, Wanhai Xu

Targeting STAT3 in Cancer Immunotherapy

Sailan Zou, Qiyu Tong, Bowen Liu, Wei Huang, Yan Tian, Xianghui Fu

The role of ubiquitination and deubiquitination in cancer metabolism

  • Open Access
  • Review

Tianshui Sun, Zhuonan Liu, Qing Yang

Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing

Xiaoshi Ma, Jinan Guo, Kaisheng Liu, Lipeng Chen, Dale Liu, Shaowei Dong, Jinquan Xia, Qiaoyun Long, Yongjian Yue, Pan Zhao, Fengyan Hu, Zhangang Xiao, Xinghua Pan, Kefeng Xiao, Zhiqiang Cheng, Zunfu Ke, Zhe-Sheng Chen, Chang Zou

Correction to: Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence

  • Open Access
  • Correction

Junming Bi, Hongwei Liu, Wei Dong, Weibin Xie, Qingqing He, Zijian Cai, Jian Huang, Tianxin Lin

Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy

Ying Wang, Yunjing Zhang, Ping Wang, Xianghui Fu, Weiqiang Lin

Treatment monitoring of colorectal cancer by integrated analysis of plasma concentration and sequencing of circulating tumor DNA

Yu-Min Yeh, Peng-Chan Lin, Chung-Ta Lee, Shang-Hung Chen, Bo-Wen Lin, Shao-Chieh Lin, Po-Chuan Chen, Ren-Hao Chan, Meng-Ru Shen

CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc

Shuying Shen, Teng Yao, Yining Xu, Deguang Zhang, Shunwu Fan, Jianjun Ma

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer

Jiangfeng Li, Haiyun Xie, Yufan Ying, Hong Chen, Huaqing Yan, Liujia He, Mingjie Xu, Xin Xu, Zhen Liang, Ben Liu, Xiao Wang, Xiangyi Zheng, Liping Xie

Correction to: EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis

Renjie Wang, Sai Zhang, Xuyi Chen, Nan Li, Jianwei Li, Ruichao Jia, Yuanqing Pan, Haiqian Liang

The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors

Ying Jin, Dong-Liang Chen, Feng Wang, Chao-pin Yang, Xu-Xian Chen, Jin-qi You, Jin-Sheng Huang, Yang Shao, Dong-Qin Zhu, Yu-Ming Ouyang, Hui-Yan Luo, Zhi-Qiang Wang, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu, Dong-Sheng Zhang

The PVT1 lncRNA is a novel epigenetic enhancer of MYC, and a promising risk-stratification biomarker in colorectal cancer

Kunitoshi Shigeyasu, Shusuke Toden, Tsuyoshi Ozawa, Takatoshi Matsuyama, Takeshi Nagasaka, Toshiaki Ishikawa, Debashis Sahoo, Pradipta Ghosh, Hiroyuki Uetake, Toshiyoshi Fujiwara, Ajay Goel

circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2

Lei Peng, Huaiming Sang, Shuchun Wei, Yuanyuan Li, Duochen Jin, Xudong Zhu, Xuan Li, Yini Dang, Guoxin Zhang

Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit

Cunying Ma, Xiaoying Wang, Fenghua Yang, Yichen Zang, Jiansong Liu, Xinyi Wang, Xia Xu, Wenjuan Li, Jihui Jia, Zhifang Liu

Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy

Bin Zhang, Ping Cheng

Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer

Wanjun Gu, Junchao Shi, Hui Liu, Xudong Zhang, Jin J. Zhou, Musheng Li, Dandan Zhou, Rui Li, Jingzhu Lv, Guoxia Wen, Shanshan Zhu, Ting Qi, Wei Li, Xiaojing Wang, Zhaohua Wang, Hua Zhu, Changcheng Zhou, Kenneth S. Knox, Ting Wang, Qi Chen, Zhongqing Qian, Tong Zhou

Exosome-based immunotherapy: a promising approach for cancer treatment

Zhijie Xu, Shuangshuang Zeng, Zhicheng Gong, Yuanliang Yan

A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer

  • Open Access
  • Shock
  • Letter to the Editor

Jung Min Park, Yoon-Jae Kim, Soeun Park, Minsu Park, Lee Farrand, Cong-Truong Nguyen, Jihyae Ann, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ji Young Kim, Jae Hong Seo

Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies

  • Open Access
  • Letter to the Editor

Chaoting Zhang, Heyilimu Palashati, Zhuona Rong, Ningjing Lin, Luyan Shen, Ying Liu, Shance Li, Bentong Yu, Wenjun Yang, Zheming Lu

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Junjie Xu, Zhe Wan, Minyue Tang, Zhongjie Lin, Shi Jiang, Lin Ji, Kirill Gorshkov, Qijiang Mao, Shunjie Xia, Dong Cen, Junhao Zheng, Xiao Liang, Xiujun Cai

The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation

Liang-Yan Chen, Lian Wang, Yue-Xiang Ren, Zheng Pang, Yao Liu, Xiao-Dong Sun, Jian Tu, Zheng Zhi, Yan Qin, Li-Na Sun, Jian-Ming Li

Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

Xiufang Xu, Miaofeng Zhang, Faying Xu, Shaojie Jiang

circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

  • Open Access
  • Research

Wei Gao, Huina Guo, Min Niu, Xiwang Zheng, Yuliang Zhang, Xuting Xue, Yunfeng Bo, Xiaoya Guan, Zhongxun Li, Yujia Guo, Long He, Yu Zhang, Li Li, Jimin Cao, Yongyan Wu

Long noncoding RNAs: functions and mechanisms in colon cancer

Sian Chen, Xian Shen

CSN8 is a key regulator in hypoxia-induced epithelial–mesenchymal transition and dormancy of colorectal cancer cells

Songwen Ju, Feng Wang, Yirong Wang, Songguang Ju

Programmable N6-methyladenosine modification of CDCP1 mRNA by RCas9-methyltransferase like 3 conjugates promotes bladder cancer development

Xiaoling Ying, Xu Jiang, Haiqing Zhang, Bixia Liu, Yapeng Huang, Xiaowei Zhu, Defeng Qi, Gang Yuan, Junhang Luo, Weidong Ji

The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?

Robert Ballotti, Yann Cheli, Corine Bertolotto

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

Simeng Wen, Yulei Wei, Chong Zen, Wei Xiong, Yuanjie Niu, Yu Zhao

Circular RNA: metabolism, functions and interactions with proteins

  • Open Access
  • Review

Wei-Yi Zhou, Ze-Rong Cai, Jia Liu, De-Shen Wang, Huai-Qiang Ju, Rui-Hua Xu

Correction to: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer

  • Open Access
  • Correction

Haihai Liang, Xiaoguang Zhao, Chengyu Wang, Jian Sun, Yingzhun Chen, Guoyuan Wang, Lei Fang, Rui Yang, Mengxue Yu, Yunyan Gu, Hongli Shan

Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Ajaz A. Bhat, Salma N. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Santosh K. Yadav, Wael El-Rifai, Mohammad A. Zargar, Hatem Zayed, Mohammad Haris, Shahab Uddin

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Keynote webinar | Spotlight on progress in colorectal cancer

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
Watch now
Image Credits
Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images