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Open Access 01-12-2019 | Central Nervous System Trauma | Review article

Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review

Authors: Eigil Lindekilde Larsen, Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Kristoffer Seem, Messoud Ashina, Sait Ashina, Henrik Winther Schytz

Published in: The Journal of Headache and Pain | Issue 1/2019

Abstract

Background

Post-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH treatment. Thus, we found it timely to provide a systematic review of the current literature on acute and preventive pharmacological treatment of PTH using PubMed and Embase databases.

Findings

Included studies involved acute and preventive pharmacological treatment of headache attributed to traumatic injury to the head in adherence to the International Classification of Headache Disorders (ICHD) criteria. Of 1424 potentially relevant articles identified, 63 were retrieved for detailed evaluation and seven studies (one prospective and six retrospective) met the inclusion criteria. None of the seven included studies were randomized clinical trials (RCTs) or used a placebo-controlled study design.

Conclusion

We found that there is a lack of high-quality evidence-based studies on the pharmacological treatment of PTH. Future studies are highly needed and must emphasize open-label studies with rigorous methodology or RCTs with a placebo-controlled design.

Nampiaparampil DE (2014) Prevalence of chronic pain after traumatic brain injury a systematic review. Clin Corner 300(6):711–719

D’Onofrio F, Russo A, Conte F, Casucci G, Tessitore A, Tedeschi G (2014) Post-traumatic headaches: an epidemiological overview. Neurol Sci 35(SUPPL. 1):203–207CrossRef

Baandrup L, Jensen R (2005) Chronic post-traumatic headache - a clinical analysis in relation to the international headache classification 2nd edition. Cephalalgia. 25(2):132–138CrossRef

Ashina H, Porreca F, Anderson T, Mohammad Amin F, Ashina M, Winther Schytz, et al. Post-traumatic headache: epidemiology and pathophysiological insights. Nat Rev Neurol. 2019; [Epub ahead of print]

Seifert TD, Evans RW (2010) Posttraumatic headache: a review. Curr Pain Headache Rep 14(4):292–298CrossRef

Lucas S (2015) Posttraumatic headache: clinical characterization and management. Curr Pain Headache Rep 19(10):1–9CrossRef

Zeeberg P, Olesen J, Jensen R (2005) Efficacy of multidisciplinary treatment in a tertiary referral headache Centre. Cephalalgia. 25(12):1159–1167CrossRef

Headache Classification Committee of the International Headache Society (IHS) (2018) The international classification of headache disorders, 3rd edition. Cephalalgia. 38(1):1–211CrossRef

Seeger TA, Orr S, Bodell L, Lockyer L, Rajapakse T, Barlow KM. Occipital nerve blocks for pediatric posttraumatic headache: a case series. J child Neurol [internet]. 2015;30(9):1142–1146. Available from: https://doi.org/10.1177/0883073814553973 CrossRef

10.

Dubrovsky AS, Friedman D, Kocilowicz H (2014) Pediatric post-traumatic headaches and peripheral nerve blocks of the scalp: a case series and patient satisfaction survey. Headache. 54(5):878–887CrossRef

11.

Friedman BW, Babbush K, Irizarry E, White D, John Gallagher E. An exploratory study of IV metoclopramide + diphenhydramine for acute post-traumatic headache. Am J Emerg med [internet]. 2018;36(2):285–289. Available from: https://doi.org/10.1016/j.ajem.2017.10.034 CrossRef

12.

Chan S, Kurowski B, Byczkowski T, Timm N. Intravenous migraine therapy in children with posttraumatic headache in the ED. Am J Emerg Med [Internet] 2015;33(5):635–639. Available from: https://doi.org/10.1016/j.ajem.2015.01.053 CrossRef

13.

Cushman DM, Borowski L, Hansen C, Hendrick J, Bushman T, Teramoto M (2019) Gabapentin and Tricyclics in the treatment of post-concussive headache, a retrospective cohort study. Headache. 59(3):371–382CrossRef

14.

Kuczynski A, Crawford S, Bodell L, Dewey D, Barlow KM (2013) Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Dev Med Child Neurol 55(7):636–641CrossRef

15.

Erickson JC (2011) Treatment outcomes of chronic post-traumatic headaches after mild head trauma in us soldiers: an observational study. Headache. 51(6):932–944CrossRef

16.

Macedo A, Farré M, Baños JE (2006) A meta-analysis of the placebo response in acute migraine and how this response may be influenced by some of the characteristics of clinical trials. Eur J Clin Pharmacol 62(3):161–172CrossRef

17.

Diener HC, Agosti R, Allais G, Bergmans P, Bussone G, Davies B et al (2007) Cessation versus continuation of 6-month migraine preventive therapy with topiramate (PROMPT): a randomised, double-blind, placebo-controlled trial. Lancet Neurol 6(12):1054–1062CrossRef

18.

Silberstein SD, Lipton RB, Dodick DW, Freitag FG, Ramadan N, Mathew N et al (2007) Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. Headache. 47(2):170–180CrossRef

19.

Powers SW, Coffey CS, Chamberlin LA, Ecklund DJ, Klingner EA, Yankey JW et al (2016) Trial of amitriptyline, Topiramate, and placebo for pediatric migraine. N Engl J Med 376(2):115–124CrossRef

20.

Tassorelli C, Diener HC, Dodick DW, Silberstein SD, Lipton RB, Ashina M et al (2018) Guidelines of the international headache society for controlled trials of preventive treatment of chronic migraine in adults. Cephalalgia. 38(5):815–832CrossRef

21.

Diener HC, Tassorelli C, Dodick DW, Silberstein SD, Lipton RB, Ashina M et al (2019) Guidelines of the international headache society for controlled trials of acute treatment of migraine attacks in adults: fourth edition. Cephalalgia. 39(6):687–710CrossRef

22.

Russo A, D’Onofrio F, Conte F, Petretta V, Tedeschi G, Tessitore A (2014) Post-traumatic headaches: a clinical overview. Neurol Sci 35(SUPPL. 1):153–157CrossRef

Title: Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review
Authors: Eigil Lindekilde Larsen
Håkan Ashina
Afrim Iljazi
Haidar Muhsen Al-Khazali
Kristoffer Seem
Messoud Ashina
Sait Ashina
Henrik Winther Schytz
Publication date: 01-12-2019
Publisher: Springer Milan
Keywords: Central Nervous System Trauma
Migraine
Traumatic Brain Injuries
Headache
Amitriptyline
Triptan Drugs
Published in: The Journal of Headache and Pain / Issue 1/2019
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-019-1051-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review

Abstract

Background

Findings

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Findings

Conclusion

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