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Current Nutrition Reports
Published in: Current Nutrition Reports 3/2019

01-09-2019 | Nutrition | Cancer (MF Leitzmann, Section Editor)

Nutritional Metabolomics in Cancer Epidemiology: Current Trends, Challenges, and Future Directions

Authors: Emma E. McGee, Rama Kiblawi, Mary C. Playdon, A. Heather Eliassen

Published in: Current Nutrition Reports | Issue 3/2019

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Abstract

Purpose of Review

Metabolomics offers several opportunities for advancement in nutritional cancer epidemiology; however, numerous research gaps and challenges remain. This narrative review summarizes current research, challenges, and future directions for epidemiologic studies of nutritional metabolomics and cancer.

Recent Findings

Although many studies have used metabolomics to investigate either dietary exposures or cancer, few studies have explicitly investigated diet-cancer relationships using metabolomics. Most studies have been relatively small (≤ ~ 250 cases) or have assessed a limited number of nutritional metabolites (e.g., coffee or alcohol-related metabolites).

Summary

Nutritional metabolomic investigations of cancer face several challenges in study design; biospecimen selection, handling, and processing; diet and metabolite measurement; statistical analyses; and data sharing and synthesis. More metabolomics studies linking dietary exposures to cancer risk, prognosis, and survival are needed, as are biomarker validation studies, longitudinal analyses, and methodological studies. Despite the remaining challenges, metabolomics offers a promising avenue for future dietary cancer research.
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Metadata
Title
Nutritional Metabolomics in Cancer Epidemiology: Current Trends, Challenges, and Future Directions
Authors
Emma E. McGee
Rama Kiblawi
Mary C. Playdon
A. Heather Eliassen
Publication date
01-09-2019
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 3/2019
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-019-00279-z

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