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Current Nutrition Reports

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01-09-2019 | Nutrition | Cardiovascular Disease (JHY Wu, Section Editor)

Quantity, Quality, and Timing of Carbohydrate Intake and Blood Pressure

Authors: Stephanie S. Byun, Zara K. Mayat, Brooke Aggarwal, Niyati Parekh, Nour Makarem

Published in: Current Nutrition Reports | Issue 3/2019

Abstract

Purpose of Review

This review discusses recent evidence on the association of dietary carbohydrates (quantity, quality, and timing of intake) with hypertension (HTN) risk and out-of-clinic blood pressure (BP) measures.

Recent Findings

Studies on carbohydrate quantity are inconclusive, but low carbohydrate diets may be associated with lower BP. Plant-based carbohydrate-containing foods such as fruits, vegetables, and whole grains may lower HTN risk and 24-h BP. Excessive sugar intakes from sugar-sweetened beverages are associated with higher BP levels and HTN risk, with evidence of a dose-response relationship. Preliminary data suggest that timing of carbohydrate intake may influence HTN risk and 24-h BP.

Summary

The role of carbohydrate nutrition in HTN’s etiology warrants further investigation. Additional studies are needed to investigate the influence of dietary carbohydrates on HTN risk and the circadian pattern of BP, evaluate potential sex and racial/ethnic differences in these associations, and elucidate underlying mechanisms.

Bromfield S, Muntner P. High blood pressure: the leading global burden of disease risk factor and the need for worldwide prevention programs. Curr Hypertens Rep. 2013;15(3):134–6. https://doi.org/10.1007/s11906-013-0340-9.CrossRefPubMedPubMedCentral

Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2017;71(6):e13–e115. https://doi.org/10.1161/HYP.0000000000000065.CrossRefPubMed

Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. Lancet. 2014;383(9932):1899–911. https://doi.org/10.1016/s0140-6736(14)60685-1.CrossRefPubMedPubMedCentral

• Hardy ST, Loehr LR, Butler KR, Chakladar S, Chang PP, Folsom AR, et al. Reducing the blood pressure-related burden of cardiovascular disease: impact of achievable improvements in blood pressure prevention and control. J Am Heart Assoc. 2015;4(10):e002276. https://doi.org/10.1161/JAHA.115.002276 This study provides evidence that modest improvements in blood pressure at the population level may have a substantial impact on cardiovascular disease prevention.CrossRefPubMedPubMedCentral

Forman JP, Stampfer MJ, Curhan GC. Diet and lifestyle risk factors associated with incident hypertension in women. JAMA. 2009;302(4):401–11. https://doi.org/10.1001/jama.2009.1060.CrossRefPubMedPubMedCentral

Bazzano LA, Green T, Harrison TN, Reynolds K. Dietary approaches to prevent hypertension. Curr Hypertens Rep. 2013;15(6):694–702. https://doi.org/10.1007/s11906-013-0390-z.CrossRefPubMedPubMedCentral

Gay HC, Rao SG, Vaccarino V, Ali MK. Effects of different dietary interventions on blood pressure. Hypertension. 2016;67(4):733–9. https://doi.org/10.1161/hypertensionaha.115.06853.CrossRefPubMed

Ndanuko RN, Tapsell LC, Charlton KE, Neale EP, Batterham MJ. Dietary patterns and blood pressure in adults: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2016;7(1):76–89. https://doi.org/10.3945/an.115.009753.CrossRefPubMedPubMedCentral

Brader L, Uusitupa M, Dragsted LO, Hermansen K. Effects of an isocaloric healthy Nordic diet on ambulatory blood pressure in metabolic syndrome: a randomized SYSDIET sub-study. Eur J Clin Nutr. 2014;68(1):57–63. https://doi.org/10.1038/ejcn.2013.192.CrossRefPubMed

10.

Mozaffarian D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity. Circulation. 2016;133(2):187–225. https://doi.org/10.1161/circulationaha.115.018585.CrossRefPubMedPubMedCentral

11.

Chan Q, Stamler J, Griep LM, Daviglus ML, Horn LV, Elliott P. An update on nutrients and blood pressure. J Atheroscler Thromb. 2016;23(3):276–89. https://doi.org/10.5551/jat.30000.CrossRefPubMed

12.

Samadian F, Dalili N, Jamalian A. Lifestyle modifications to prevent and control hypertension. Iran J Kidney Dis. 2016;10(5):237–63.

13.

Te Morenga LA, Howatson AJ, Jones RM, Mann J. Dietary sugars and cardiometabolic risk: systematic review and meta-analyses of randomized controlled trials of the effects on blood pressure and lipids. Am J Clin Nutr. 2014;100(1):65–79. https://doi.org/10.3945/ajcn.113.081521.CrossRef

14.

He FJ, MacGregor GA. Salt and sugar: their effects on blood pressure. Pflugers Arch. 2015;467(3):577–86. https://doi.org/10.1007/s00424-014-1677-x.CrossRefPubMed

15.

• St-Onge MP, Ard J, Baskin ML, Chiuve SE, Johnson HM, Kris-Etherton P, et al. Meal timing and frequency: implications for cardiovascular disease prevention: a scientific statement from the American Heart Association. Circulation. 2017;135(9):e96–e121. https://doi.org/10.1161/CIR.0000000000000476 This statement from the American Heart Association summarizes the evidence on the role of meal timing, including the timing of macronutrient intake, in cardiometabolic health. CrossRefPubMed

16.

Makarem N, Aggarwal B, Sears DD, St-Onge M-P, Castañeda SF, Talavera GA, et al. Abstract 11503: circadian timing of food intake is associated with cardiometabolic risk in US Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos. Circulation. 2018;138:A11503.

17.

Morris CJ, Purvis TE, Mistretta J, Scheer FAJL. Effects of the internal circadian system and circadian misalignment on glucose tolerance in chronic shift workers. J Clin Endocrinol Metab. 2016;101(3):1066–74. https://doi.org/10.1210/jc.2015-3924.CrossRefPubMedPubMedCentral

18.

Douma LG, Gumz ML. Circadian clock-mediated regulation of blood pressure. Free Radic Biol Med. 2018;119:108–14. https://doi.org/10.1016/j.freeradbiomed.2017.11.024.CrossRefPubMed

19.

United States Department of Agriculture, Agricultural Research Service (2018) What We Eat in America Data Tables [database on the Internet]. Available from: https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/food-surveys-research-group/docs/wweia-data-tables/. Accessed: January 8, 2019.

20.

Food and Agriculture Organization of the United Nations (2017) Food Balance Sheets 2013. http://www.fao.org/faostat/en/#data/FBS/report. Accessed January 8 2019.

21.

U.S. Department of Health and Human Services and U.S. Department of Agriculture (2015) 2015–2020 Dietary Guidelines for Americans. http://health.gov/dietaryguidelines/2015/guidelines/. Accessed January 8, 2019 8th Edition.

22.

Reicks M, Jonnalagadda S, Albertson AM, Joshi N. Total dietary fiber intakes in the US population are related to whole grain consumption: results from the National Health and Nutrition Examination Survey 2009 to 2010. Nutr Res. 2014;34(3):226–34. https://doi.org/10.1016/j.nutres.2014.01.002.CrossRefPubMed

23.

Rosinger A, Herrick KA, Gahche J, Park S. Sugar-sweetened beverage consumption among U.S. adults, 2011-2014. In: NCHS Data Brief. Centers for Disease Control and Prevention. 2017. https://www.cdc.gov/nchs/products/databriefs/db270.htm. Accessed January 7 2019.

24.

Khan TA, Sievenpiper JL. Controversies about sugars: results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes. Eur J Nutr. 2016;55(Suppl 2):25–43. https://doi.org/10.1007/s00394-016-1345-3.CrossRefPubMedPubMedCentral

25.

Suliga E, Koziel D, Ciesla E, Rebak D, Gluszek S. Dietary patterns in relation to metabolic syndrome among adults in Poland: a cross-sectional study. Nutrients. 2017;9(12). https://doi.org/10.3390/nu9121366.

26.

Bozzetto L, Costabile G, Della Pepa G, Ciciola P, Vetrani C, Vitale M, et al. Dietary fibre as a unifying remedy for the whole spectrum of obesity-associated cardiovascular risk. Nutrients. 2018;10(7). https://doi.org/10.3390/nu10070943.

27.

Makarem N, Nicholson JM, Bandera EV, McKeown NM, Parekh N. Consumption of whole grains and cereal fiber in relation to cancer risk: a systematic review of longitudinal studies. Nutr Rev. 2016;74(6):353–73. https://doi.org/10.1093/nutrit/nuw003.CrossRefPubMedPubMedCentral

28.

Gnatiuc L, Alegre-Diaz J, Halsey J, Herrington WG, Lopez-Cervantes M, Lewington S, et al. Adiposity and blood pressure in 110 000 Mexican adults. Hypertension. 2017;69(4):608–14. https://doi.org/10.1161/HYPERTENSIONAHA.116.08791.CrossRefPubMedPubMedCentral

29.

Kovacic JC, Castellano JM, Farkouh ME, Fuster V. The relationships between cardiovascular disease and diabetes: focus on pathogenesis. Endocrinol Metab Clin N Am. 2014;43(1):41–57. https://doi.org/10.1016/j.ecl.2013.09.007.CrossRef

30.

Bernardes N, Ayyappan P, De Angelis K, Bagchi A, Akolkar G, da Silva Dias D, et al. Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation. Can J Physiol Pharmacol. 2017;95(10):1078–90. https://doi.org/10.1139/cjpp-2016-0663.CrossRefPubMed

31.

Klein AV, Kiat H. The mechanisms underlying fructose-induced hypertension: a review. J Hypertens. 2015;33(5):912–20. https://doi.org/10.1097/HJH.0000000000000551.CrossRefPubMedPubMedCentral

32.

Preuss HG, Clouatre D, Swaroop A, Bagchi M, Bagchi D, Kaats GR. Blood pressure regulation: reviewing evidence for interplay between common dietary sugars and table salt. J Am Coll Nutr. 2017;36(8):677–84. https://doi.org/10.1080/07315724.2017.1345338.CrossRefPubMed

33.

Pilic L, Pedlar CR, Mavrommatis Y. Salt-sensitive hypertension mechanisms and effects of dietary and other lifestyle factors. Nutr Rev. 2016;74(10):645–58. https://doi.org/10.1093/nutrit/nuw028.CrossRefPubMed

34.

Bandin C, Scheer FA, Luque AJ, Avila-Gandia V, Zamora S, Madrid JA, et al. Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: a randomized, crossover trial. Int J Obes. 2015;39(5):828–33. https://doi.org/10.1038/ijo.2014.182.CrossRef

35.

Song S, Song Y. Three types of a high-carbohydrate diet are differently associated with cardiometabolic risk factors in Korean adults. Eur J Nutr. 2018. https://doi.org/10.1007/s00394-018-1871-2.

36.

•• Mente A, Dehghan M, Rangarajan S, McQueen M, Dagenais G, Wielgosz A, et al. Association of dietary nutrients with blood lipids and blood pressure in 18 countries: a cross-sectional analysis from the PURE study. Lancet Diabetes Endocrinol. 2017;5(10):774–87. https://doi.org/10.1016/S2213-8587(17)30283-8 This landmark study demonstrates that carbohydrate intake in the highest versus lowest quintile is associated with higher mean systolic blood pressure using data from 18 countries. CrossRefPubMed

37.

Pal A, De S, Sengupta P, Maity P, Dhara PC. Relationship of body compositional and nutritional parameters with blood pressure in adults. J Hum Nutr Diet. 2014;27(5):489–500. https://doi.org/10.1111/jhn.12180.CrossRefPubMed

38.

• Lelong H, Blacher J, Baudry J, Adriouch S, Galan P, Fezeu L, et al. Individual and combined effects of dietary factors on risk of incident hypertension: prospective analysis from the NutriNet-Sante Cohort. Hypertension. 2017;70(4):712–20. https://doi.org/10.1161/HYPERTENSIONAHA.117.09622 This prospective study demonstrates that carbohydrate intake in the highest versus lowest quartile is associated with lower odds of hypertension. CrossRefPubMed

39.

Jayalath VH, Sievenpiper JL, de Souza RJ, Ha V, Mirrahimi A, Santaren ID, et al. Total fructose intake and risk of hypertension: a systematic review and meta-analysis of prospective cohorts. J Am Coll Nutr. 2014;33(4):328–39. https://doi.org/10.1080/07315724.2014.916237.CrossRefPubMedPubMedCentral

40.

Forman JP, Choi H, Curhan GC. Fructose and vitamin C intake do not influence risk for developing hypertension. J Am Soc Nephrol. 2009;20(4):863–71. https://doi.org/10.1681/ASN.2008050473.CrossRefPubMedPubMedCentral

41.

Santos FL, Esteves SS, da Costa Pereira A, Yancy WS, Nunes JP. Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors. Obes Rev. 2012;13(11):1048–66. https://doi.org/10.1111/j.1467-789X.2012.01021.x.CrossRefPubMed

42.

Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS, Brehm BJ, et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006;166(3):285–93. https://doi.org/10.1001/archinte.166.3.285.CrossRefPubMed

43.

Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER, et al. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA. 2005;294(19):2455–64. https://doi.org/10.1001/jama.294.19.2455.CrossRefPubMed

44.

Bazzano LA, Hu T, Reynolds K, Yao L, Bunol C, Liu Y, et al. Effects of low-carbohydrate and low-fat diets: a randomized trial. Ann Intern Med. 2014;161(5):309–18. https://doi.org/10.7326/M14-0180.CrossRefPubMedPubMedCentral

45.

Foraker RE, Pennell M, Sprangers P, Vitolins MZ, DeGraffinreid C, Paskett ED. Effect of a low-fat or low-carbohydrate weight-loss diet on markers of cardiovascular risk among premenopausal women: a randomized trial. J Women's Health (Larchmt). 2014;23(8):675–80. https://doi.org/10.1089/jwh.2013.4638.CrossRef

46.

Jenkins DJ, Wolever TM, Jenkins AL, Josse RG, Wong GS. The glycaemic response to carbohydrate foods. Lancet. 1984;2(8399):388–91.CrossRef

47.

Atkinson FS, Foster-Powell K, Brand-Miller JC. International tables of glycemic index and glycemic load values: 2008. Diabetes Care. 2008;31(12):2281–3. https://doi.org/10.2337/dc08-1239.CrossRefPubMedPubMedCentral

48.

Ludwig DS. The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA. 2002;287(18):2414–23.CrossRef

49.

de Mello Fontanelli M, Sales CH, Carioca AAF, Marchioni DM, Fisberg RM. The relationship between carbohydrate quality and the prevalence of metabolic syndrome: challenges of glycemic index and glycemic load. Eur J Nutr. 2018;57(3):1197–205. https://doi.org/10.1007/s00394-017-1402-6.CrossRefPubMed

50.

Clar C, Al-Khudairy L, Loveman E, Kelly SA, Hartley L, Flowers N, et al. Low glycaemic index diets for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2017;(7):CD004467. https://doi.org/10.1002/14651858.CD004467.pub3.

51.

• Evans CE, Greenwood DC, Threapleton DE, Gale CP, Cleghorn CL, Burley VJ. Glycemic index, glycemic load, and blood pressure: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2017;105(5):1176–90. https://doi.org/10.3945/ajcn.116.143685 Recent meta-analysis of 14 randomized clinical trials providing evidence that low glycemic index and glycemic load diets may lead to significant reductions in blood pressure. CrossRefPubMed

52.

Philippou E, Bovill-Taylor C, Rajkumar C, Vampa ML, Ntatsaki E, Brynes AE, et al. Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study. Metabolism. 2009;58(12):1703–8. https://doi.org/10.1016/j.metabol.2009.05.026.CrossRefPubMed

53.

McKeown NM, Meigs JB, Liu S, Wilson PW, Jacques PF. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr. 2002;76(2):390–8. https://doi.org/10.1093/ajcn/76.2.390.CrossRefPubMed

54.

• Kelly SA, Hartley L, Loveman E, Colquitt JL, Jones HM, Al-Khudairy L, et al. Whole grain cereals for the primary or secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2017;8:CD005051. https://doi.org/10.1002/14651858.CD005051.pub3 A meta-analysis of seven randomized clinical trials showing that interventions that increase whole grain intake are associated with non-significant decreases in blood pressure. CrossRefPubMed

55.

•• Reynolds A, Mann J, Cummings J, Winter N, Mete E, Te Morenga L. Carbohydrate quality and human health: a series of systematic reviews and meta-analyses. Lancet. 2019;393:434–45. https://doi.org/10.1016/S0140-6736(18)31809-9 This systematic review and meta-analysis of eight clinical trials demonstrates that those in the highest versus lowest category of whole grain intake have lower systolic blood pressure. CrossRefPubMed

56.

• Schwingshackl L, Schwedhelm C, Hoffmann G, Knuppel S, Iqbal K, Andriolo V, et al. Food groups and risk of hypertension: a systematic review and dose-response meta-analysis of prospective studies. Adv Nutr. 2017;8(6):793–803. https://doi.org/10.3945/an.117.017178 A meta-analysis of prospective studies providing evidence that increased consumption of whole grains is associated with a decreased risk of hypertension. CrossRefPubMedPubMedCentral

57.

Kirwan JP, Malin SK, Scelsi AR, Kullman EL, Navaneethan SD, Pagadala MR, et al. A whole-grain diet reduces cardiovascular risk factors in overweight and obese adults: a randomized controlled trial. J Nutr. 2016;146(11):2244–51. https://doi.org/10.3945/jn.116.230508.CrossRefPubMedPubMedCentral

58.

Tripkovic L, Muirhead NC, Hart KH, Frost GS, Lodge JK. The effects of a diet rich in inulin or wheat fibre on markers of cardiovascular disease in overweight male subjects. J Hum Nutr Diet. 2015;28(5):476–85. https://doi.org/10.1111/jhn.12251.CrossRefPubMed

59.

• Borgi L, Muraki I, Satija A, Willett WC, Rimm EB, Forman JP. Fruit and vegetable consumption and the incidence of hypertension in three prospective cohort studies. Hypertension. 2016;67(2):288–93. https://doi.org/10.1161/HYPERTENSIONAHA.115.06497 This study examines the association between fruit and vegetable intake and incidence of hypertension in three major US cohorts. Findings demonstrate that higher consumption of fruits and vegetables is associated with a decreased risk of hypertension. CrossRefPubMed

60.

Hong SA, Kim MK. Relationship between fruit and vegetable intake and the risk of metabolic syndrome and its disorders in Korean women according to menopausal status. Asia Pac J Clin Nutr. 2017;26(3):514–23. https://doi.org/10.6133/apjcn.042016.03.CrossRefPubMed

61.

Malik AH, Akram Y, Shetty S, Malik SS, Yanchou Njike V. Impact of sugar-sweetened beverages on blood pressure. Am J Cardiol. 2014;113(9):1574–80. https://doi.org/10.1016/j.amjcard.2014.01.437.CrossRefPubMed

62.

Kim Y, Je Y. Prospective association of sugar-sweetened and artificially sweetened beverage intake with risk of hypertension. Arch Cardiovasc Dis. 2016;109(4):242–53. https://doi.org/10.1016/j.acvd.2015.10.005.CrossRefPubMed

63.

Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, et al. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. 2007;116(5):480–8. https://doi.org/10.1161/CIRCULATIONAHA.107.689935.CrossRefPubMed

64.

Cohen L, Curhan G, Forman J. Association of sweetened beverage intake with incident hypertension. J Gen Intern Med. 2012;27(9):1127–34. https://doi.org/10.1007/s11606-012-2069-6.CrossRefPubMedPubMedCentral

65.

Pase MP, Grima N, Cockerell R, Pipingas A. Habitual intake of fruit juice predicts central blood pressure. Appetite. 2015;84:68–72. https://doi.org/10.1016/j.appet.2014.09.019.CrossRefPubMed

66.

Sayon-Orea C, Martinez-Gonzalez MA, Gea A, Alonso A, Pimenta AM, Bes-Rastrollo M. Baseline consumption and changes in sugar-sweetened beverage consumption and the incidence of hypertension: the SUN project. Clin Nutr. 2015;34(6):1133–40. https://doi.org/10.1016/j.clnu.2014.11.010.CrossRefPubMed

67.

Kawano Y. Diurnal blood pressure variation and related behavioral factors. Hypertens Res. 2011;34(3):281–5. https://doi.org/10.1038/hr.2010.241.CrossRefPubMed

68.

Witbracht M, Keim NL, Forester S, Widaman A, Laugero K. Female breakfast skippers display a disrupted cortisol rhythm and elevated blood pressure. Physiol Behav. 2015;140:215–21. https://doi.org/10.1016/j.physbeh.2014.12.044.CrossRefPubMed

69.

Odegaard AO, Jacobs DR Jr, Steffen LM, Van Horn L, Ludwig DS, Pereira MA. Breakfast frequency and development of metabolic risk. Diabetes Care. 2013;36(10):3100–6. https://doi.org/10.2337/dc13-0316.CrossRefPubMedPubMedCentral

70.

Haus E, Reinberg A, Mauvieux B, Le Floc’h N, Sackett-Lundeen L, Touitou Y. Risk of obesity in male shift workers: a chronophysiological approach. Chronobiol Int. 2016;33(8):1018–36. https://doi.org/10.3109/07420528.2016.1167079.CrossRefPubMed

71.

Shihab HM, Meoni LA, Chu AY, Wang NY, Ford DE, Liang KY, et al. Body mass index and risk of incident hypertension over the life course: the Johns Hopkins Precursors Study. Circulation. 2012;126(25):2983–9. https://doi.org/10.1161/CIRCULATIONAHA.112.117333.CrossRefPubMedPubMedCentral

72.

Spaeth AM, Dinges DF, Goel N. Sex and race differences in caloric intake during sleep restriction in healthy adults. Am J Clin Nutr. 2014;100(2):559–66. https://doi.org/10.3945/ajcn.114.086579.CrossRefPubMedPubMedCentral

73.

Wismann J, Willoughby D. Gender differences in carbohydrate metabolism and carbohydrate loading. J Int Soc Sports Nutr. 2006;3:28–34. https://doi.org/10.1186/1550-2783-3-1-28.CrossRefPubMedPubMedCentral

74.

Therkelsen KE, Pedley A, Speliotes EK, Massaro JM, Murabito J, Hoffmann U, et al. Intramuscular fat and associations with metabolic risk factors in the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2013;33(4):863–70. https://doi.org/10.1161/ATVBAHA.112.301009.CrossRefPubMedPubMedCentral

75.

Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr. 2007;86(4):899–906. https://doi.org/10.1093/ajcn/86.4.899.CrossRefPubMed

76.

Howard G, Cushman M, Moy CS, Oparil S, Muntner P, Lackland DT, et al. Association of clinical and social factors with excess hypertension risk in black compared with white US adults. JAMA. 2018;320(13):1338–48. https://doi.org/10.1001/jama.2018.13467.CrossRefPubMedPubMedCentral

77.

Sharma S, Sheehy T, Kolonel L. Sources of vegetables, fruits and vitamins A, C and E among five ethnic groups: results from a multiethnic cohort study. Eur J Clin Nutr. 2014;68(3):384–91. https://doi.org/10.1038/ejcn.2013.271.CrossRefPubMedPubMedCentral

78.

Thompson FE, McNeel TS, Dowling EC, Midthune D, Morrissette M, Zeruto CA. Interrelationships of added sugars intake, socioeconomic status, and race/ethnicity in adults in the United States: National Health Interview Survey, 2005. J Am Diet Assoc. 2009;109(8):1376–83. https://doi.org/10.1016/j.jada.2009.05.002.CrossRefPubMedPubMedCentral

79.

DiNicolantonio JJ, Lucan SC. The wrong white crystals: not salt but sugar as aetiological in hypertension and cardiometabolic disease. Open Heart. 2014;1(1):e000167. https://doi.org/10.1136/openhrt-2014-000167.CrossRefPubMedPubMedCentral

80.

Schisler JC, Charles PC, Parker JS, Hilliard EG, Mapara S, Meredith D, et al. Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry. PLoS One. 2009;4(12):e8183. https://doi.org/10.1371/journal.pone.0008183.CrossRefPubMedPubMedCentral

81.

Chandalia M, Lin P, Seenivasan T, Livingston EH, Snell PG, Grundy SM, et al. Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. PLoS One. 2007;2(8):e812. https://doi.org/10.1371/journal.pone.0000812.CrossRefPubMedPubMedCentral

82.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72. https://doi.org/10.1001/jama.289.19.2560.CrossRef

Title: Quantity, Quality, and Timing of Carbohydrate Intake and Blood Pressure
Authors: Stephanie S. Byun
Zara K. Mayat
Brooke Aggarwal
Niyati Parekh
Nour Makarem
Publication date: 01-09-2019
Publisher: Springer US
Keywords: Nutrition
Hypertension
Hypertension
Published in: Current Nutrition Reports / Issue 3/2019
Electronic ISSN: 2161-3311
DOI: https://doi.org/10.1007/s13668-019-00277-1

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