Skip to main content
Top
Published in: Dermatology and Therapy 2/2020

Open Access 01-04-2020 | Alopecia | Case Series

Lichen Planopilaris and Low-Level Light Therapy: Four Case Reports and Review of the Literature About Low-Level Light Therapy and Lichenoid Dermatosis

Authors: Michael J. Randolph, Waleed Al Salhi, Antonella Tosti

Published in: Dermatology and Therapy | Issue 2/2020

Login to get access

Abstract

Lichen planopilaris (LPP) is a cell-mediated scarring alopecia that causes inflammation of the scalp and the eventual destruction of hair follicles in affected areas. Current literature on treatment of LPP remains limited with no definitive treatment approach being recognized, although a combination of topical/intralesional steroids and orally administered hydroxychloroquine remains the most utilized option. Low-level light therapy (LLLT) is an expanding technology shown to be effective in a variety of dermatologic conditions. We report here four patients with LPP who show a dramatic response to LLLT, including a reduction of inflammation, disappearance of symptoms, and evident hair regrowth with no side effects. We review the possible role of LLLT in LPP and other lichenoid conditions.
Literature
1.
go back to reference Harries MJ, Meyer K, Chaudhry I, et al. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle’s epithelial stem cell niche. J Pathol. 2013;231(2):236–47.CrossRefPubMed Harries MJ, Meyer K, Chaudhry I, et al. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle’s epithelial stem cell niche. J Pathol. 2013;231(2):236–47.CrossRefPubMed
2.
go back to reference Avci P, Gupta A, Sadasivam M, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg. 2013;32(1):41–52.PubMedPubMedCentral Avci P, Gupta A, Sadasivam M, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg. 2013;32(1):41–52.PubMedPubMedCentral
3.
go back to reference Barolet D, Boucher A. Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series. Lasers Surg Med. 2010;42(6):597–601.CrossRefPubMed Barolet D, Boucher A. Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series. Lasers Surg Med. 2010;42(6):597–601.CrossRefPubMed
4.
go back to reference Koh MJA, Mok ZR, Chong WS. Phototherapy for the treatment of vitiligo in Asian children. Pediatr Dermatol. 2015;32(2):192–7.CrossRefPubMed Koh MJA, Mok ZR, Chong WS. Phototherapy for the treatment of vitiligo in Asian children. Pediatr Dermatol. 2015;32(2):192–7.CrossRefPubMed
5.
go back to reference Lee SY, Park KH, Choi JW, et al. A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem Photobiol B Biol. 2007;88(1):51–67.CrossRef Lee SY, Park KH, Choi JW, et al. A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem Photobiol B Biol. 2007;88(1):51–67.CrossRef
6.
go back to reference Fonda-Pascual P, Moreno-Arrones OM, Saceda-Corralo D, et al. Effectiveness of low-level laser therapy in lichen planopilaris. J Am Acad Dermatol. 2018;78(5):1020–3.CrossRefPubMed Fonda-Pascual P, Moreno-Arrones OM, Saceda-Corralo D, et al. Effectiveness of low-level laser therapy in lichen planopilaris. J Am Acad Dermatol. 2018;78(5):1020–3.CrossRefPubMed
7.
go back to reference Gerkowicz A, Bartosińska J, Wolska-Gawron K, Michalska-Jakubus M, Kwaśny M, Krasowska D. Application of superluminescent diodes (sLED) in the treatment of scarring alopecia: a pilot study. Photodiagnosis Photodyn Ther. 2019;28:195–200.CrossRefPubMed Gerkowicz A, Bartosińska J, Wolska-Gawron K, Michalska-Jakubus M, Kwaśny M, Krasowska D. Application of superluminescent diodes (sLED) in the treatment of scarring alopecia: a pilot study. Photodiagnosis Photodyn Ther. 2019;28:195–200.CrossRefPubMed
8.
go back to reference Dillenburg CS, Martins MAT, Munerato MC, et al. Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial. J Biomed Opt. 2014;19(6):068002.CrossRefPubMed Dillenburg CS, Martins MAT, Munerato MC, et al. Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial. J Biomed Opt. 2014;19(6):068002.CrossRefPubMed
10.
go back to reference El Shenawy HM, Eldin AM. A comparative evaluation of low-level laser and topical steroid therapies for the treatment of erosive-atrophic lichen planus. Maced J Med Sci. 2015;3(3):462–6.CrossRef El Shenawy HM, Eldin AM. A comparative evaluation of low-level laser and topical steroid therapies for the treatment of erosive-atrophic lichen planus. Maced J Med Sci. 2015;3(3):462–6.CrossRef
11.
go back to reference Jajarm HH, Falaki F, Mahdavi O. A comparative pilot study of low intensity laser versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus. Photomed Laser Surg. 2011;29(6):421–5.CrossRefPubMed Jajarm HH, Falaki F, Mahdavi O. A comparative pilot study of low intensity laser versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus. Photomed Laser Surg. 2011;29(6):421–5.CrossRefPubMed
12.
go back to reference Kazancioglu HO, Erisen M. Comparison of low-level laser therapy versus ozone therapy in the treatment of oral lichen planus. Ann Dermatol. 2015;27(5):485–91.CrossRefPubMedPubMedCentral Kazancioglu HO, Erisen M. Comparison of low-level laser therapy versus ozone therapy in the treatment of oral lichen planus. Ann Dermatol. 2015;27(5):485–91.CrossRefPubMedPubMedCentral
13.
go back to reference Othman NA, Shaker OG, Elshenawy HM, Abd-Elmoniem W, Eldin AM, Fakhr MY. The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients. J Clin Exp Dent. 2016;8(5):e566–70.PubMedPubMedCentral Othman NA, Shaker OG, Elshenawy HM, Abd-Elmoniem W, Eldin AM, Fakhr MY. The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients. J Clin Exp Dent. 2016;8(5):e566–70.PubMedPubMedCentral
14.
go back to reference Lyakhovitsky A, Amichai B, Sizopoulou C, Barzilai A. A case series of 46 patients with lichen planopilaris: demographics, clinical evaluation, and treatment experience. J Dermatol Treat. 2015;26(3):275–9.CrossRef Lyakhovitsky A, Amichai B, Sizopoulou C, Barzilai A. A case series of 46 patients with lichen planopilaris: demographics, clinical evaluation, and treatment experience. J Dermatol Treat. 2015;26(3):275–9.CrossRef
19.
go back to reference Errichetti E, Figini M, Croatto M, Stinco G. Therapeutic management of classic lichen planopilaris: a systematic review. Clin Cosmet Investig Dermatol. 2018;11:91–102.CrossRefPubMedPubMedCentral Errichetti E, Figini M, Croatto M, Stinco G. Therapeutic management of classic lichen planopilaris: a systematic review. Clin Cosmet Investig Dermatol. 2018;11:91–102.CrossRefPubMedPubMedCentral
21.
go back to reference Strazzulla LC, Avila L, Lo KS, Shapiro J. Novel treatment using low-dose naltrexone for lichen planopilaris. J Drugs Dermatol. 2017;16(11):1140–2.PubMed Strazzulla LC, Avila L, Lo KS, Shapiro J. Novel treatment using low-dose naltrexone for lichen planopilaris. J Drugs Dermatol. 2017;16(11):1140–2.PubMed
Metadata
Title
Lichen Planopilaris and Low-Level Light Therapy: Four Case Reports and Review of the Literature About Low-Level Light Therapy and Lichenoid Dermatosis
Authors
Michael J. Randolph
Waleed Al Salhi
Antonella Tosti
Publication date
01-04-2020
Publisher
Springer Healthcare
Published in
Dermatology and Therapy / Issue 2/2020
Print ISSN: 2193-8210
Electronic ISSN: 2190-9172
DOI
https://doi.org/10.1007/s13555-020-00359-x

Other articles of this Issue 2/2020

Dermatology and Therapy 2/2020 Go to the issue