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Nuclear Medicine and Molecular Imaging
Published in: Nuclear Medicine and Molecular Imaging 4/2019

Open Access 01-08-2019 | Radioimmunotherapy | Review

Measurement of Tumor Pressure and Strategies of Imaging Tumor Pressure for Radioimmunotherapy

Authors: Hyeon-gi Kim, A. Ram Yu, Jae Joon Lee, Yong-Jin Lee, Sang Moo Lim, Jin Su Kim

Published in: Nuclear Medicine and Molecular Imaging | Issue 4/2019

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Abstract

Tumor interstitial pressure is a fundamental feature of cancer biology. Elevation in tumor pressure affects the efficacy of cancer treatment and results in the heterogenous intratumoral distribution of drugs and macromolecules. Monoclonal antibodies (mAb) play a prominent role in cancer therapy and molecular nuclear imaging. Therapy using mAb labeled with radionuclides—also known as radioimmunotherapy (RIT)—is an effective form of cancer treatment. RIT is clinically effective for the treatment of lymphoma and other blood cancers; however, its clinical use for solid tumor was limited because their high interstitial pressure prevents mAb from penetrating into the tumor. This pressure can be decreased using anti-cancer drugs or additional external therapy. In this paper, we reviewed the intratumoral pressure using direct tumor-pressure measurement strategies, such as the wick-in-needle and pressure catheter transducer method, and indirect tumor-pressure measurement strategies via magnetic resonance.
Literature
1.
Liu LJ, Brown SL, Ewing JR, Ala BD, Schneider KM, Schlesinger M. Estimation of tumor interstitial fluid pressure (TIFP) noninvasively. PLoS One. 2016;11:e0140892.CrossRefPubMedCentralPubMed
2.
Cavin S, Wang X, Zellweger M, Gonzalez M, Bensimon M, Wagnieres G, et al. Interstitial fluid pressure: a novel biomarker to monitor photo-induced drug uptake in tumor and normal tissues. Lasers Surg Med. 2017;49:773–80.CrossRefPubMed
3.
Ariffin AB, Forde PF, Jahangeer S, Soden DM, Hinchion J. Releasing pressure in tumors: what do we know so far and where do we go from here? A review. Cancer Res. 2014;74:2655–62.CrossRefPubMed
4.
Erdi AK, Erdi YE, Yorke ED, Wessels BW. Treatment planning for radio-immunotherapy. Phys Med Biol. 1996;41:2009–26.CrossRefPubMed
5.
6.
7.
8.
Zhang M, Yao Z, Zhang Z, Garmestani K, Talanov VS, Plascjak PS, et al. The anti-CD25 monoclonal antibody 7G7/B6, armed with the alpha-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia. Cancer Res. 2006;66:8227–32.CrossRefPubMed
9.
Jang BS, Lee SM, Kim HS, Shin IS, Razjouyan F, Wang S, et al. Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab. Nucl Med Biol. 2012;39:472–83.CrossRefPubMed
10.
Khaibullina A, Jang B-S, Sun H, Le N, Yu S, Frenkel V, et al. Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice. J Nucl Med. 2008;49:295–302.CrossRefPubMed
11.
Heldin CH, Rubin K, Pietras K, Ostman A. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer. 2004;4:806–13.CrossRefPubMed
12.
Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK. Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res. 1991;51:6695–8.PubMed
13.
Milosevic M, Fyles A, Hedley D, Pintilie M, Levin W, Manchul L, et al. Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res. 2001;61:6400–5.PubMed
14.
15.
16.
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;21:418–29.CrossRefPubMedCentralPubMed
17.
Stohrer M, Boucher Y, Stangassinger M, Jain RK. Oncotic pressure in solid tumors is elevated. Cancer Res. 2000;60:4251–5.PubMed
18.
Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK. Pathology: cancer cells compress intratumour vessels. Nature. 2004;427:695.CrossRefPubMed
19.
Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, et al. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012;109:15101–8.CrossRefPubMedCentralPubMed
20.
Nieskoski MD, Marra K, Gunn JR, Kanick SC, Doyley MM, Hasan T, et al. Separation of solid stress from interstitial fluid pressure in pancreas cancer correlates with collagen area fraction. J Biomech Eng. 2017;139.
21.
Scholander PF, Hargens AR, Miller SL. Negative pressure in the interstitial fluid of animals. Fluid tensions are spectacular in plants; in animals they are elusively small, but just as vital. Science. 1968;161:321–8.CrossRefPubMed
22.
Reulen HJ, Graham R, Spatz M, Klatzo I. Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurg. 1977;46:24–35.CrossRefPubMed
23.
Thompson CB, Shepard HM, O’Connor PM, Kadhim S, Jiang P, Osgood RJ, et al. Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models. Mol Cancer Ther. 2010;9:3052–64.CrossRefPubMed
24.
Zimmer HG, Millar HD. Technology and application of ultraminiature catheter pressure transducers. Can J Cardiol. 1998;14:1259–66.PubMed
25.
DuFort CC, DelGiorno KE, Hingorani SR. Mounting pressure in the microenvironment: fluids, solids, and cells in pancreatic ductal adenocarcinoma. Gastroenterology. 2016;150:1545–57 e2.CrossRefPubMed
26.
DelGiorno KE, Carlson MA, Osgood R, Provenzano PP, Brockenbough JS, Thompson CB, et al. Response to Chauhan et Al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning. Cancer Cell. 2014;26:16–7.CrossRefPubMedCentralPubMed
27.
28.
29.
Thomassin-Naggara I, De Bazelaire C, Chopier J, Bazot M, Marsault C, Trop I. Diffusion-weighted MR imaging of the breast: advantages and pitfalls. Eur J Radiol. 2013;82:435–43.CrossRefPubMed
30.
Padhani AR, Liu G, Koh DM, Chenevert TL, Thoeny HC, Takahara T, et al. Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia. 2009;11:102–25.CrossRefPubMedCentralPubMed
31.
Hompland T, Ellingsen C, Galappathi K, Rofstad EK. DW-MRI in assessment of the hypoxic fraction, interstitial fluid pressure, and metastatic propensity of melanoma xenografts. BMC Cancer. 2014;14:92.CrossRefPubMedCentralPubMed
32.
Yankeelov TE, Arlinghaus LR, Li X, Gore JC. The role of magnetic resonance imaging biomarkers in clinical trials of treatment response in cancer. Semin Oncol. 2011;38:16–25.CrossRefPubMedCentralPubMed
33.
Zhai G, Grubbs CJ, Stockard CR, Umphrey HR, Beasley TM, Kim H. Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. PLoS One. 2013;8:e64445.CrossRefPubMedCentralPubMed
34.
Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK. Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer. Oncotarget. 2017;8:105682–91.PubMedCentralPubMed
35.
Walker-Samuel S, Roberts TA, Ramasawmy R, Burrell JS, Johnson SP, Siow BM, et al. Investigating low-velocity fluid flow in tumors with convection-MRI. Cancer Res. 2018;78:1859–72.CrossRefPubMedCentralPubMed
36.
Less JR, Posner MC, Boucher Y, Borochovitz D, Wolmark N, Jain RK. Interstitial hypertension in human breast and colorectal tumors. Cancer Res. 1992;52:6371–4.PubMed
37.
Nathanson SD, Nelson L. Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma. Ann Surg Oncol. 1994;1:333–8.CrossRefPubMed
38.
Curti BD, Urba WJ, Alvord WG, Janik JE, Smith JW 2nd, Madara K, et al. Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. Cancer Res. 1993;53:2204–7.PubMed
39.
Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res. 1991;51:6691–4.PubMed
40.
Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, et al. Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. Cancer Res. 1992;52:1993–5.PubMed
41.
Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, et al. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun. 2013;4:2516.CrossRefPubMed
42.
Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery. Cancer Res. 1995;55:5451–8.PubMed
43.
Beyer I, Cao H, Persson J, Song H, Richter M, Feng Q, et al. Coadministration of epithelial junction opener JO-1 improves the efficacy and safety of chemotherapeutic drugs. Clin Cancer Res. 2012;18:3340–51.CrossRefPubMedCentralPubMed
44.
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 2004;64:3731–6.CrossRefPubMed
45.
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004;10:145–7.CrossRefPubMedCentralPubMed
46.
Eikenes L, Bruland OS, Brekken C, Davies CL. Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts. Cancer Res. 2004;64:4768–73.CrossRefPubMed
47.
Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A. 2011;108:2909–14.CrossRefPubMedCentralPubMed
Metadata
Title
Measurement of Tumor Pressure and Strategies of Imaging Tumor Pressure for Radioimmunotherapy
Authors
Hyeon-gi Kim
A. Ram Yu
Jae Joon Lee
Yong-Jin Lee
Sang Moo Lim
Jin Su Kim
Publication date
01-08-2019
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 4/2019
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-019-00598-7

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