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Nuclear Medicine and Molecular Imaging
Published in: Nuclear Medicine and Molecular Imaging 4/2019

01-08-2019 | Wound Infection | Original Article

Utility of FDG-PET/CT for the Detection and Characterization of Sternal Wound Infection Following Sternotomy

Authors: Hadi Hariri, Stéphanie Tan, Patrick Martineau, Yoan Lamarche, Michel Carrier, Vincent Finnerty, Sébastien Authier, Francois Harel, Matthieu Pelletier-Galarneau

Published in: Nuclear Medicine and Molecular Imaging | Issue 4/2019

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Abstract

Purpose

FDG-PET/CT has the potential to play an important role in the diagnosis of sternal wound infections (SWI). The purpose of this study was to analyze the diagnostic accuracy of FDG-PET/CT for SWI in patients following sternotomy.

Methods

We performed a single-center, retrospective analysis of patients who had undergone median sternotomy and FDG-PET/CT imaging. The gold standard consisted of positive bacterial culture and/or the presence of purulent material at surgery. Qualitative patterns of sternal FDG uptake, SUVmax, and associated CT findings were determined, and an imaging scoring system was developed. The diagnostic performances were studied in both the recent (≤ 6 months between sternotomy and imaging) and remote surgery phase (> 6 months).

Results

A total of 40 subjects were identified with 11 confirmed SWI cases. Consensus interpretation was associated with a sensitivity of 91% and specificity of 97%. Combination of uptake patterns yielded an AUC of 0.96 while use of SUVmax yielded an AUC of 0.82.

Conclusions

Results suggest that FDG-PET/CT may be useful for the diagnosis of SWI with optimal diagnostic accuracy achieved by identifying specific patterns of uptake. SUVmax can be helpful in assessing subjects with remote surgery, but its use is limited in the context of recent surgery. Further studies are required to confirm these results.
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Metadata
Title
Utility of FDG-PET/CT for the Detection and Characterization of Sternal Wound Infection Following Sternotomy
Authors
Hadi Hariri
Stéphanie Tan
Patrick Martineau
Yoan Lamarche
Michel Carrier
Vincent Finnerty
Sébastien Authier
Francois Harel
Matthieu Pelletier-Galarneau
Publication date
01-08-2019
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 4/2019
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-019-00599-6

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