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The journal of nutrition, health & aging

Published in:

01-07-2016

Sarcopenic obesity: An appraisal of the current status of knowledge and management in elderly people

Authors: S. Molino, M. Dossena, D. Buonocore, Manuela Verri

Published in: The journal of nutrition, health & aging | Issue 7/2016

Abstract

Today’s increased life expectancy highlights both age-related changes in body composition and a higher prevalence of obesity. Sarcopenic obesity (SO) is assuming a prominent role in cardio-metabolic risk because of the double metabolic burden derived from low muscle mass (sarcopenia) and excess adiposity (obesity). This review evaluates the related studies that have been published over the past 10 years in order to give an updated overview of this new syndrome. There is no consensus on the definition of SO due to the wide heterogeneity of diagnostic criteria and choice of body composition components needed to assess this phenotype. There is a growing body of evidence that the ethio-pathogenesis of SO is complex and multi-factorial, as the consequences are a combination of the outcomes of both sarcopenia and obesity, where the effects are maximised. In order to manage SO, it is important to make lifestyle changes that incorporate weight loss, physical exercise and protein supplementation.

The World Bank Group Population ages 65 and above (% of total). Available at: http://data.worldbank.org/indicator/SP.POP.65UP.TO.ZS/countries/XC-US-EU-Z7-7E?display=graph

Eurostat TSO of the EU Proportion of population aged 65 and over. Available at: http://ec.europa.eu/eurostat/tgm/table.do?tab=table&init=1&language=en&pcode=tps00028

Visser M, Goodpaster BH, Kritchevsky SB, Newman AB, Nevitt M, Rubin SM, Simonsick EM, Harris TB. Muscle Mass, Muscle Strength, and Muscle Fat Infiltration as Predictors of Incident Mobility Limitations in Well-Functioning Older Persons. J Gerontol A Biol Sci Med Sci 2005;60: 324–333. doi:10.1093/gerona/60.3.324PubMedCrossRef

Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, Boudreau R, Manini TM, Nevitt M, Newman AB, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 2009;90: 1579–1585. doi:10.3945/ajcn.2009.28047PubMedPubMedCentralCrossRef

Poggiogalle E, Migliaccio S, Lenzi A, Donini LM. Treatment of body composition changes in obese and overweight older adults: insight into the phenotype of sarcopenic obesity. Endocrine 2014;47: 699–716. doi:10.1007/s12020-014-0315-xPubMedCrossRef

Bouchard DR, Beliaeff S, Dionne IJ, Brochu M. Fat Mass But Not Fat-Free Mass Is Related to Physical Capacity in Well-Functioning Older Individuals: Nutrition as a Determinant of Successful Aging (NuAge)—The Quebec Longitudinal Study. J Gerontol A Biol Sci Med Sci 2007;62: 1382–1388. doi:10.1093/gerona/62.12.1382PubMedCrossRef

Rosenberg IH. Symposium: Sarcopenia: Diagnosis and Mechanisms Sarcopenia: Origins and Clinical Relevance. J Nutr 1997;127: 990–991.

Thomas DR. Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia. Clin Nutr 2007;26: 389–99. doi:10.1016/j. clnu.2007.03.008PubMedCrossRef

Nilwik R, Snijders T, Leenders M, Groen BBL, van Kranenburg J, Verdijk LB, van Loon LJC. The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size. Exp Gerontol 2013;48: 492–498. doi:10.1016/j. exger.2013.02.012PubMedCrossRef

10.

Fielding R, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan van Kan G, Andrieu S, Bauer J, Breuille D, et al. Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia. J Am Med Dir Assoc 2011;12: 249–256. doi:10.1016/j.jamda.2011.01.003PubMed

11.

Abellan van Kan G. Epidemiology and consequences of sarcopenia. J Nutr Health Aging 2009;13: 708–12.CrossRef

12.

Goodpaster B, Park S, Harris T, Kritchevsky S, Nevitt M, Schwartz A, Simonsick E, Tylavsky F, Visser M, Newman A. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 2006;61: 1059–1064.PubMedCrossRef

13.

Clark BC, Manini TM. What is dynapenia? Nutrition 2012;28: 495–503. doi:10.1016/j.nut.2011.12.002PubMedPubMedCentralCrossRef

14.

Woo J, Leung J, Morley JE. Defining sarcopenia in terms of incident adverse outcomes. J Am Med Dir Assoc 2015;16: 247–52. doi:10.1016/j.jamda.2014.11.013PubMedCrossRef

15.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel J-P, Rolland Y, Schneider SM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39: 412–23. doi:10.1093/ageing/afq034PubMedPubMedCentralCrossRef

16.

Bijlsmaa. Y, Meskers CGM, Ling CHY, Narici M, Kurrle SE, Cameron ID, Westendorp RGJ, Maiera. B. Defining sarcopenia: The impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort. Age (Omaha) 2013;35: 871–881. doi:10.1007/s11357-012-9384-zCrossRef

17.

Serra Rexach J. Consecuencias clinicas de la sarcopenia. Nutr Hosp 2006;21: 46–50.PubMed

18.

Lang T, Streeper T, Cawthon P, Baldwin K, Taaffe DR, Harris TB. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int 2010;21: 543–59. doi:10.1007/s00198-009-1059-yPubMedCrossRef

19.

Landi F, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R, Onder G. Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clin Nutr 2012;31: 652–8. doi:10.1016/j.clnu.2012.02.007PubMedCrossRef

20.

Wang C, Bai L. Sarcopenia in the elderly: basic and clinical issues. Geriatr Gerontol Int 2012;12: 388–96. doi:10.1111/j.1447-0594.2012.00851.xPubMedCrossRef

21.

Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of Sarcopenia and Predictors of Skeletal Muscle Mass in Healthy, Older Men and Women. J Gerontol A Biol Sci Med Sci 2002;57: M772–M777. doi:10.1093/gerona/57.12.M772PubMedCrossRef

22.

Kob R, Bollheimer LC, Bertsch T, Fellner C, Djukic M, Sieber CC, Fischer BE. Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis? Biogerontology 1014;16: 15–29. doi:10.1007/s10522-014-9539-7PubMedCrossRef

23.

Forbes SC, Little JP, Candow DG. Exercise and nutritional interventions for improving aging muscle health. Endocrine 2012;42: 29–38. doi:10.1007/s12020-012-9676-1PubMedCrossRef

24.

Kuk JL, Saunders TJ, Davidson LE, Ross R. Age-related changes in total and regional fat distribution. Ageing Res Rev 2009;8: 339–48. doi:10.1016/j. arr.2009.06.001PubMedCrossRef

25.

Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: A new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 2008;18: 388–395. doi:10.1016/j.numecd.2007.10.002PubMedCrossRef

26.

Blaum CS, Xue QL, Michelon E, Semba RD, Fried LP. The association between obesity and the frailty syndrome in older women: the Women’s Health and Aging Studies. J Am Geriatr Soc 2005;53: 927–34. doi:10.1111/j.1532-5415.2005.53300.xPubMedCrossRef

27.

Sarkisian CA, Liu H, Gutierrez PR, Seeley DG, Cummings SR, Mangione CM. Modifiable risk factors predict functional decline among older women: a prospectively validated clinical prediction tool. The Study of Osteoporotic Fractures Research Group. J Am Geriatr Soc 2000;48: 170–8.PubMed

28.

Hiraki T, Gobara H, Mimura H, Sano Y, Kanazawa S. Excess baggage: sarcopenia, obesity, and cancer outcomes. Lancet Oncol 2008;9: 605–607.CrossRef

29.

Benton MJ, Whyte MD, Dyal BW. Sarcopenic obesity: strategies for management. Am J Nurs 2011;111: 38–44; quiz 45–6. doi:10.1097/01.NAJ.0000408184.21770.98PubMedCrossRef

30.

Baumgartner RN, Wayne SJ, Waters DL, Janssen I, Gallagher D, Morley JE. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res 12004;2: 1995–2004. doi:10.1038/oby.2004.250CrossRef

31.

Cauley JA. An Overview of Sarcopenic Obesity. J Clin Densitom, 2015; doi:10.1016/j.jocd.2015.04.013

32.

Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998;147: 755–63.PubMedCrossRef

33.

Gallagher D, Visser M, de Meersman RE, Sepulveda D, Baumgartner RN, Pierson RN, Harris T, Heymsfield SB (1997) Appendicular skeletal muscle mass: effects of age, gender, and ethnicity. J Appl Physiol, 1997;83: 229–239.PubMed

34.

Davison KK, Ford ES, Cogswell ME, Dietz WH (2002) Percentage of body fat and body mass index are associated with mobility limitations in people aged 70 and older from NHANES III. J Am Geriatr Soc, 2002;50: 1802–9.PubMedCrossRef

35.

Zoico E, Di Francesco V, Guralnik JM, Mazzali G, Bortolani A, Guariento S, Sergi G, Bosello O, Zamboni M (2004) Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women. Int J Obes Relat Metab Disord, 2004;28: 234–41. doi:10.1038/sj.ijo.0802552PubMed

36.

Kim J, Wang Z, Heymsfield SB, Baumgartner RN, Gallagher D (2002) Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method. Am J Clin Nutr, 2002;76: 378–83.PubMed

37.

Heymsfield S, Smith R, Aulet M, Bensen B, Lichtman S, Wang J, Pierson, RN J (1990) Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr, 1990;52: 214–218.PubMed

38.

Schrager MA, Metter EJ, Simonsick E, Ble A, Lauretani F, Ferrucci L (2007) Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol, 2007;102: 919–925. doi:10.1152/japplphysiol.00627.2006PubMedCrossRef

39.

Bouchard DR, Dionne IJ, Brochu M (2009) Sarcopenic/obesity and physical capacity in older men and women: data from the Nutrition as a Determinant of Successful Aging (NuAge)-the Quebec longitudinal Study. Obesity (Silver Spring), 2009;17: 2082–8. doi:10.1038/oby.2009.109CrossRef

40.

Kim TN, Yang SJ, Yoo HJ, Lim KI, Kang HJ, Song W, Seo J a, Kim SG, Kim NH, Baik SH, et al. (2009) Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study. Int J Obes, 2009;33: 885–892. doi:10.1038/ijo.2009.130CrossRef

41.

Levine ME, Crimmins EM (2012) The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning. Obesity (Silver Spring), 2012;20: 2101–6. doi:10.1038/oby.2012.20CrossRef

42.

Waters DL, Baumgartner RN (2011) Sarcopenia and obesity. Clin Geriatr Med, 2011;27: 401–21. doi:10.1016/j.cger.2011.03.007PubMedCrossRef

43.

Batsis Ja, Barre LK, Mackenzie Ta, Pratt SI, Lopez-Jimenez F, Bartels SJ (2013) Variation in the prevalence of sarcopenia and sarcopenic obesity in older adults associated with different research definitions: Dual-energy X-ray absorptiometry data from the National Health and Nutrition Examination Survey 1999-2004. J Am Geriatr Soc, 2013;61: 974–980. doi:10.1111/jgs.12260PubMedCrossRef

44.

Han TS, Tajar A, Lean MEJ (2011) Obesity and weight management in the elderly. Br Med Bull, 2011;97: 169–196. doi:10.1093/bmb/ldr002PubMedCrossRef

45.

Prado CMM, Wells JCK, Smith SR, Stephan BCM, Siervo M (2012) Sarcopenic obesity: A Critical appraisal of the current evidence. Clin Nutr, 2012;31: 583–601. doi:10.1016/j.clnu.2012.06.010PubMedCrossRef

46.

Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L (2008) Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care, 2008;11: 693–700. doi:10.1097/MCO.0b013e328312c37dPubMedPubMedCentralCrossRef

47.

Sakuma K, Yamaguchi A (2013) Sarcopenic obesity and endocrinal adaptation with age. Int J Endocrinol 2013: doi:10.1155/2013/204164

48.

Zamboni M, Mazzali G, Zoico E, Harris TB, Meigs JB, Di Francesco V, Fantin F, Bissoli L, Bosello O (2005) Health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes (Lond), 2005;29: 1011–29. doi:10.1038/sj.ijo.0803005CrossRef

49.

Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S (2007) Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans. Diabetes, 2007;56: 4–7. doi:10.2337/db06-1656.CRPCrossRef

50.

Woodrow G (2009) Body composition analysis techniques in the aged adult: indications and limitations. Curr Opin Clin Nutr Metab Care, 2009;12: 8–14. doi:10.1097/MCO.0b013e32831b9c5bPubMedCrossRef

51.

Guillet C, Boirie Y (2005) Insulin resistance: a contributing factor to age-related muscle mass loss? Diabetes Metab 2005;2: 5S20–5S26. doi:10.1016/S1262-3636(05)73648-X

52.

Nilsson MI, Dobson JP, Greene NP, Wiggs MP, Shimkus KL, Wudeck E V, Davis AR, Laureano ML, Fluckey JD (2013) Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity. FASEB J, 2013;27: 3905–16. doi:10.1096/fj.12-224006PubMedCrossRef

53.

Kim TN, Park MS, Lim KIl, Choi HY, Yang SJ, Yoo HJ, Kang HJ, Song W, Choi H, Baik SH, et al. (2013) Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: The Korean Sarcopenic Obesity Study. Clin Endocrinol (Oxf), 2013;78: 525–532. doi:10.1111/j.1365-2265.2012.04433.xCrossRef

54.

Kohara K, Ochi M, Tabara Y, Nagai T, Igase M, Miki T (2011) Leptin in sarcopenic visceral obesity: Possible link between adipocytes and myocytes. PLoS One, 2011;6: doi:10.1371/journal.pone.0024633

55.

Fulgoni VL (2008) Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr, 2008;87: 1554S–1557S.PubMed

56.

Hays NP, Roberts SB (2006) The anorexia of aging in humans. Physiol Behav, 2006;88: 257–266. doi:10.1016/j.physbeh.2006.05.029PubMedCrossRef

57.

Rolland Y, Czerwinski S, Abellan Van Kan G, Morley JE, Cesari M, Onder G, Woo J, Baumgartner R, Pillard F, Boirie Y, et al. (2008) Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging, 2008;12: 433–50.PubMedPubMedCentralCrossRef

58.

Srikanthan P, Hevener AL, Karlamangla AS (2010) Sarcopenia exacerbates obesityassociated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS One, 2010;5: e10805. doi:10.1371/journal. pone.0010805PubMedPubMedCentralCrossRef

59.

Lim S, Kim JH, Kang SM, Choi SH, Park YJ, Kim KW, Lim JY, Park KS, Jang HC (2010) Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean longitudinal study on health and aging. Diabiates Care, 2010;33: 1652–1654. doi:10.2337/dc10-0107.S.L.CrossRef

60.

Kim J, Cho JJ, Park YS (2015) Relationship between Sarcopenic Obesity and Cardiovascular Disease Risk as Estimated by the Framingham Risk Score. J Korean Med Sci, 2015;30: 264–271.PubMedPubMedCentralCrossRef

61.

Stephen WC, Janssen I (2009) Sarcopenic-obesity and cardiovascular disease risk in the elderly. J Nutr Health Aging, 2009;13: 460–466.PubMedCrossRef

62.

Janssen I, Katzmarzyk PT, Ross R (2005) Body mass index is inversely related to mortality in older people after adjustment for waist circumference. J Am Geriatr Soc, 2005;53: 2112–8. doi:10.1111/j.1532-5415.2005.00505.xPubMedCrossRef

63.

Monteiro M, Gabriel R, Aranha J, Nevese Castro M, Sousa M, Moreira M (2010) Influence of obesity and sarcopenic obesity on plantar pressure of postmenopausal women. Clin Biomech (Bristol, Avon), 2010;25: 461–7. doi:10.1016/j. clinbiomech.2010.01.017CrossRef

64.

Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, Baracos VE (2008) Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol, 2008;9: 629–635. doi:10.1016/S1470-2045(08)70153-0PubMedCrossRef

65.

Lim JP, Ding YY, Ismail NH, Yew S (2015) Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clin Interv Aging, 2015;10: 605–609.PubMedPubMedCentral

66.

Honda H, Qureshi AR, Axelsson J, Heimburger O, Suliman ME, Barany P, Stenvinkel P, Lindholm B (2007) Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr, 2007;86: 633–638.PubMed

67.

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2014) Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. J Am Geriatr Soc, 2014;62: 253–60. doi:10.1111/jgs.12652PubMedCrossRef

68.

Kim TN, Choi KM (2015) The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease. J Cell Biochem, 2015;1178: 1171–8. doi:10.1002/jcb.25077CrossRef

69.

Chung JY, Kang HT, Lee DC, Lee HR, Lee YJ (2013) Body composition and its association with cardiometabolic risk factors in the elderly: A focus on sarcopenic obesity. Arch Gerontol Geriatr, 2013;56: 270–278. doi:10.1016/j.archger.2012.09.007PubMedCrossRef

70.

Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH (2006) Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical. Circulation, 2013;113: 898–918. doi:10.1161/CIRCULATIONAHA.106.1710162006PubMedCrossRef

71.

Li Z, Heber D (2012) Sarcopenic obesity in the elderly and strategies for weight management. Nutr Rev, 2012;70: 57–64. doi:10.1111/j.1753-4887.2011.00453.xPubMedCrossRef

72.

Mazzali G, Di Francesco V, Zoico E, Fantin F, Zamboni G, Benati C, Bambara V, Negri M, Bosello O, Zamboni M (2006) Interrelations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance: effect of moderate weight loss in older women. Am J Clin Nutr, 2006;84: 1193–1199.PubMed

73.

Villareal DT, Apovian CM, Kushner RF, Klein S (2005) Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res, 2005;13: 1849–63. doi:10.1038/oby.2005.228PubMedCrossRef

74.

Weinheimer EM, Sands LP, Campbell WW (2010) A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity. Nutr Rev, 2010;68: 375–88. doi:10.1111/j.1753-4887.2010.00298.xPubMedCrossRef

75.

Tiffany NF, David RS, Villareal DT (2008) Exercise Attenuates the Weight-Loss-Induced Reduction in Muscle Mass in Frail Obese Older Adults. Med Sci Sport Exerc, 2008;40: 1213–1219. doi:10.1016/j.biotechadv.2011.08.021.SecretedCrossRef

76.

Haslam DW, James WPT (2005) Obesity. Lancet, 2005;366: 1197–209. doi:10.1016/S0140-6736(05)67483-1PubMedCrossRef

77.

Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K (2011) Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med, 2011;364: 1218–1229. doi:10.1056/NEJMoa1008234PubMedPubMedCentralCrossRef

78.

Pedrero-Chamizo R, Gómez-Cabello A, Meléndez A, Vila-Maldonado S, Espino L, Gusi N, Villa G, Casajús JA, González-Gross M, Ara I (2015) Higher levels of physical fitness are associated with a reduced risk of suffering sarcopenic obesity and better perceived health among the elderly: the EXERNET multi-center study. J Nutr Health Aging, 2015;19: 211–7. doi:10.1007/s12603-014-0530-4PubMedCrossRef

79.

Marzetti E, Leeuwenburgh C (2006) Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Gerontol, 2006;41: 1234–8. doi:10.1016/j.exger.2006.08.011PubMedCrossRef

80.

Donges CE, Duffield R, Drinkwater EJ. Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition. Med Sci Sports Exerc 2010;42: 304–13. doi:10.1249/MSS.0b013e3181b117ca

81.

Negro M, Rucci S, Marzatico F. Antiaging: nutrizione e attività fisica contro l’ invecchiamento muscolare. Rivista della Società Italiana di Medicina Generale 2011;2: 19–25.

82.

Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not dietinduced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol 2008;105: 473–8. doi:10.1152/japplphysiol.00006.2008PubMedPubMedCentralCrossRef

83.

Ormsbee MJ, Prado CM, Ilich JZ, Purcell S, Siervo M, Folsom A, Panton L. Osteosarcopenic obesity: the role of bone, muscle, and fat on health. J Cachexia Sarcopenia Muscle 2014;5: 183–192. doi:10.1007/s13539-014-0146-xPubMedPubMedCentralCrossRef

84.

Sieber C, Bollheimer C, Engelke K, Kemmler W, Freiberger E. Effects of Wholebody Electromyostimulation and Dietary Supplements on “Sarcopenic Obesity.” 2015;Available at: https://clinicaltrials.gov/ct2/show/NCT02356016

85.

Theodorakopoulos C, Bannerman E. Lifestyle Modifications for the Treatment of Sarcopenic Obesity. 2015;Available at: https://clinicaltrials.gov/ct2/show/NCT02379026

86.

Wolfe RR, Miller SL, Miller KB. Optimal protein intake in the elderly. Clin Nutr 2008;27: 675–684. doi:10.1016/j.clnu.2008.06.008PubMedCrossRef

87.

Bernstein M, Munoz N. Position of the Academy of Nutrition and Dietetics: Food and Nutrition for Older Adults: Promoting Health and Wellness. J Acad Nutr Diet 2012;112: 1255–1277. doi:10.1016/j.jand.2012.06.015PubMedCrossRef

88.

Oh C, No J-K, Kim H-S. Dietary pattern classifications with nutrient intake and body composition changes in Korean elderly. Nutr Res Pract 2014;8: 192–7. doi:10.4162/nrp.2014.8.2.192PubMedPubMedCentralCrossRef

89.

Farnsworth E, Luscombe ND, Noakes M, Wittert G, Argyiou E, Clifton PM. Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women. Am J Clin Nutr 2003;78: 31–39.PubMed

90.

Weigle DS, Breen Pa., Matthys CC, Callahan HS, Meeuws KE, Burden VR, Purnell JQ. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr 2005;82: 41–48.PubMed

91.

Treyzon L, Chen S, Hong K, Yan E, Carpenter CL, Thames G, Bowerman S, Wang H-J, Elashoff R, Li Z. A controlled trial of protein enrichment of meal replacements for weight reduction with retention of lean body mass. Nutr J 2008;7: 23. doi:10.1186/1475-2891-7-23PubMedPubMedCentralCrossRef

92.

Levine ME, Suarez Ja., Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, et al. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab 2014;19: 407–417. doi:10.1016/j. cmet.2014.02.006PubMedPubMedCentralCrossRef

93.

Serra-Prat M, Papiol M, Monteis R. Relationship between plasma ghrelin levels and sarcopenia in elderly subjects: A cross-sectional study. J Nutr Health Aging 2015;19: 669–672.PubMedCrossRef

94.

EFSA. EFSA Panel on Dietetic Products, Nutrition and Allergies. EFSA J 2012;10: 2557. doi:10.2903/j.efsa.2012.2557

95.

Joint WHO/FAO/UNU Expert Consultation. Protein and amino acid requirements in human nutrition. World Heal Organ Tech Rep Ser 2007;935: 1–265, back cover.

96.

Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR. Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr 2008;87: 1562S–1566S.PubMed

97.

Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky Fa, Newman AB. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr, 2008;87: 150–155.PubMed

98.

Katsanos CS, Chinkes DL, Paddon-Jones D, Zhang X, Aarsland A, Wolfe RR. Whey protein ingestion in elderly results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res 2008;28: 651–658. doi:10.1016/j.nutres.2008.06.007PubMedPubMedCentralCrossRef

99.

Hayes A, Cribb PJ. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care 2008;11: 40–4. doi:10.1097/MCO.0b013e3282f2a57dPubMedCrossRef

100.

Antonione R, Caliandro E, Zorat F, Guarnieri G, Heer M, Biolo G. Whey protein ingestion enhances postprandial anabolism during short-term bed rest in young men. J Nutr 2008;138: 2212–2216. doi:10.3945/jn.108.086462PubMedCrossRef

101.

Coker RH, Miller S, Schutzler S, Deutz N, Wolfe RR. Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals. Nutr J 2012;11: 105. doi:10.1186/1475-2891-11-105PubMedPubMedCentralCrossRef

102.

Jain SK, Velusamy T, Croad JL, Rains JL, Bull R. l-Cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-κB activation in the livers of Zucker diabetic rats. Free Radic Biol Med 2009;46: 1633–1638. doi:10.1016/j.freeradbiomed.2009.03.014PubMedPubMedCentralCrossRef

103.

Wall BT, Hamer HM, de Lange A, Kiskini A, Groen BBL, Senden JMG, Gijsen AP, Verdijk LB, van Loon LJC. Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. Clin Nutr 2013;32: 412–419. doi:10.1016/j. clnu.2012.09.002PubMedCrossRef

104.

Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 2006;291: E381–E387. doi:10.1152/ajpendo.00488.2005PubMedCrossRef

105.

Layman DK, Walker DA. Potential Importance of Leucine in Treatment of Obesity and the Metabolic Syndrome. J Nutr 2006;136: 319S–323S.PubMed

106.

Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti P, et al. Beneficial effec ts of a long-term oral L -arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab 2006;291: 906–912. doi:10.1152/ajpendo.00002.2006CrossRef

Title: Sarcopenic obesity: An appraisal of the current status of knowledge and management in elderly people
Authors: S. Molino
M. Dossena
D. Buonocore
Manuela Verri
Publication date: 01-07-2016
Publisher: Springer Paris
Published in: The journal of nutrition, health & aging / Issue 7/2016
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-015-0631-8

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Sarcopenic obesity: An appraisal of the current status of knowledge and management in elderly people

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