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Published in: Current Cardiovascular Imaging Reports 3/2014

Open Access 01-03-2014 | Cardiac Magnetic Resonance (E Nagel and V Puntmann, Section Editors)

Myocardial Tissue Characterization: Histological and Pathophysiological Correlation

Authors: T. A. Treibel, S. K. White, J. C. Moon

Published in: Current Cardiovascular Imaging Reports | Issue 3/2014

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Abstract

Cardiovascular magnetic resonance imaging (CMR) has become the gold standard not only for cardiac volume and function quantification, but for a key unique strength: non-invasive myocardial tissue characterization. Several different techniques, separately or in combination, can detect and quantify early and established myocardial pathological processes permitting better diagnosis, prognostication and tracking of therapy. The authors will focus on the histological and pathophysiological evidence of these imaging parameters in the characterization of edema, infarction, scar and fibrosis. In addition to laying out the strengths and weaknesses of each modality, the reader will be introduced to rapid developments in T1 and T2 mapping as well as the use of contrast-derived extracellular volume for quantification of diffuse fibrosis.
Literature
2.
go back to reference Rossi MA. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens. 1998;16(7):1031–41.PubMedCrossRef Rossi MA. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens. 1998;16(7):1031–41.PubMedCrossRef
3.
go back to reference Weber KT, Brilla CG. Myocardial fibrosis and the renin-angiotensin-aldosterone system. J Cardiovasc Pharmacol. 1992;20 Suppl 1:S48–54.PubMedCrossRef Weber KT, Brilla CG. Myocardial fibrosis and the renin-angiotensin-aldosterone system. J Cardiovasc Pharmacol. 1992;20 Suppl 1:S48–54.PubMedCrossRef
4.
go back to reference Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, et al. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation. 1994;89(1):151–63.PubMedCrossRef Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, et al. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation. 1994;89(1):151–63.PubMedCrossRef
5.
go back to reference Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, et al. Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am J Cardiol. 1983;52(1):184–8.PubMedCrossRef Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, et al. Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am J Cardiol. 1983;52(1):184–8.PubMedCrossRef
6.
go back to reference Garcia-Dorado D, Oliveras J, Gili J, Sanz E, Perez-Villa F, Barrabes J, et al. Analysis of myocardial oedema by magnetic resonance imaging early after coronary artery occlusion with or without reperfusion. Cardiovasc Res. 1993;27(8):1462–9.PubMedCrossRef Garcia-Dorado D, Oliveras J, Gili J, Sanz E, Perez-Villa F, Barrabes J, et al. Analysis of myocardial oedema by magnetic resonance imaging early after coronary artery occlusion with or without reperfusion. Cardiovasc Res. 1993;27(8):1462–9.PubMedCrossRef
7.
go back to reference Aletras AH, Tilak GS, Natanzon A, Hsu LY, Gonzalez FM, Hoyt Jr RF, et al. Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Circulation. 2006;113(15):1865–70. doi:10.1161/CIRCULATIONAHA.105.576025.PubMedCrossRef Aletras AH, Tilak GS, Natanzon A, Hsu LY, Gonzalez FM, Hoyt Jr RF, et al. Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Circulation. 2006;113(15):1865–70. doi:10.​1161/​CIRCULATIONAHA.​105.​576025.PubMedCrossRef
8.
go back to reference Tilak GS, Hsu LY, Hoyt Jr RF, Arai AE, Aletras AH. In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction. Invest Radiol. 2008;43(1):7–15. doi:10.1097/RLI.0b013e3181558822.PubMedCrossRef Tilak GS, Hsu LY, Hoyt Jr RF, Arai AE, Aletras AH. In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction. Invest Radiol. 2008;43(1):7–15. doi:10.​1097/​RLI.​0b013e3181558822​.PubMedCrossRef
12.
go back to reference Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R. The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J Am Coll Cardiol. 2008;51(16):1581–7. doi:10.1016/j.jacc.2008.01.019.PubMedCrossRef Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R. The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J Am Coll Cardiol. 2008;51(16):1581–7. doi:10.​1016/​j.​jacc.​2008.​01.​019.PubMedCrossRef
13.
go back to reference Carlsson M, Ubachs JF, Hedstrom E, Heiberg E, Jovinge S, Arheden H. Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography. JACC Cardiovasc Imaging. 2009;2(5):569–76. doi:10.1016/j.jcmg.2008.11.018.PubMedCrossRef Carlsson M, Ubachs JF, Hedstrom E, Heiberg E, Jovinge S, Arheden H. Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography. JACC Cardiovasc Imaging. 2009;2(5):569–76. doi:10.​1016/​j.​jcmg.​2008.​11.​018.PubMedCrossRef
14.
16.
go back to reference Kim RJ, Chen EL, Lima JA, Judd RM. Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation. 1996;94(12):3318–26.PubMedCrossRef Kim RJ, Chen EL, Lima JA, Judd RM. Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation. 1996;94(12):3318–26.PubMedCrossRef
17.
go back to reference Flacke SJ, Fischer SE, Lorenz CH. Measurement of the gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction. Radiology. 2001;218(3):703–10.PubMedCrossRef Flacke SJ, Fischer SE, Lorenz CH. Measurement of the gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction. Radiology. 2001;218(3):703–10.PubMedCrossRef
18.
go back to reference Kim RJ, Shah DJ, Judd RM. How we perform delayed enhancement imaging. J Cardiovasc Magn Reson. 2003;5(3):505–14.PubMedCrossRef Kim RJ, Shah DJ, Judd RM. How we perform delayed enhancement imaging. J Cardiovasc Magn Reson. 2003;5(3):505–14.PubMedCrossRef
19.••
go back to reference Schelbert EB, Hsu LY, Anderson SA, Mohanty BD, Karim SM, Kellman P, et al. Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart. Circ Cardiovasc Imaging. 2010;3(6):743–52. doi:10.1161/CIRCIMAGING.108.835793. The authors have taken histological validation of LGE close to a cellular level, performing extremely high-resolution ex-vivo LGE imaging on rats at 7 Tesla and compared with histological sections showing a remarkable correlation.PubMedCentralPubMedCrossRef Schelbert EB, Hsu LY, Anderson SA, Mohanty BD, Karim SM, Kellman P, et al. Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart. Circ Cardiovasc Imaging. 2010;3(6):743–52. doi:10.​1161/​CIRCIMAGING.​108.​835793. The authors have taken histological validation of LGE close to a cellular level, performing extremely high-resolution ex-vivo LGE imaging on rats at 7 Tesla and compared with histological sections showing a remarkable correlation.PubMedCentralPubMedCrossRef
20.
go back to reference Flett AS, Hasleton J, Cook C, Hausenloy D, Quarta G, Ariti C, et al. Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance. JACC Cardiovasc Imaging. 2011;4(2):150–6. doi:10.1016/j.jcmg.2010.11.015.PubMedCrossRef Flett AS, Hasleton J, Cook C, Hausenloy D, Quarta G, Ariti C, et al. Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance. JACC Cardiovasc Imaging. 2011;4(2):150–6. doi:10.​1016/​j.​jcmg.​2010.​11.​015.PubMedCrossRef
21.
go back to reference Goldman MR, Brady TJ, Pykett IL, Burt CT, Buonanno FS, Kistler JP, et al. Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts. Circulation. 1982;66(5):1012–6.PubMedCrossRef Goldman MR, Brady TJ, Pykett IL, Burt CT, Buonanno FS, Kistler JP, et al. Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts. Circulation. 1982;66(5):1012–6.PubMedCrossRef
22.
go back to reference Wesbey GE, Higgins CB, McNamara MT, Engelstad BL, Lipton MJ, Sievers R, et al. Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium. Radiology. 1984;153(1):165–9.PubMed Wesbey GE, Higgins CB, McNamara MT, Engelstad BL, Lipton MJ, Sievers R, et al. Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium. Radiology. 1984;153(1):165–9.PubMed
23.
go back to reference Wesbey G, Higgins CB, Lanzer P, Botvinick E, Lipton MJ. Imaging and characterization of acute myocardial infarction in vivo by gated nuclear magnetic resonance. Circulation. 1984;69(1):125–30.PubMedCrossRef Wesbey G, Higgins CB, Lanzer P, Botvinick E, Lipton MJ. Imaging and characterization of acute myocardial infarction in vivo by gated nuclear magnetic resonance. Circulation. 1984;69(1):125–30.PubMedCrossRef
24.
go back to reference Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, et al. An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001;218(1):215–23.PubMedCrossRef Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, et al. An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001;218(1):215–23.PubMedCrossRef
25.
go back to reference Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999;100(19):1992–2002.PubMedCrossRef Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999;100(19):1992–2002.PubMedCrossRef
26.
go back to reference Rehwald WG, Fieno DS, Chen EL, Kim RJ, Judd RM. Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation. 2002;105(2):224–9.PubMedCrossRef Rehwald WG, Fieno DS, Chen EL, Kim RJ, Judd RM. Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation. 2002;105(2):224–9.PubMedCrossRef
27.
go back to reference Fieno DS, Kim RJ, Chen EL, Lomasney JW, Klocke FJ, Judd RM. Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing. J Am Coll Cardiol. 2000;36(6):1985–91.PubMedCrossRef Fieno DS, Kim RJ, Chen EL, Lomasney JW, Klocke FJ, Judd RM. Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing. J Am Coll Cardiol. 2000;36(6):1985–91.PubMedCrossRef
29.
30.
go back to reference Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation. 2001;104(10):1101–7.PubMedCrossRef Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation. 2001;104(10):1101–7.PubMedCrossRef
31.
go back to reference Yan AT, Shayne AJ, Brown KA, Gupta SN, Chan CW, Luu TM, et al. Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality. Circulation. 2006;114(1):32–9. doi:10.1161/CIRCULATIONAHA.106.613414.PubMedCrossRef Yan AT, Shayne AJ, Brown KA, Gupta SN, Chan CW, Luu TM, et al. Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality. Circulation. 2006;114(1):32–9. doi:10.​1161/​CIRCULATIONAHA.​106.​613414.PubMedCrossRef
32.
go back to reference Kwong RY, Chan AK, Brown KA, Chan CW, Reynolds HG, Tsang S, et al. Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation. 2006;113(23):2733–43. doi:10.1161/CIRCULATIONAHA.105.570648.PubMedCrossRef Kwong RY, Chan AK, Brown KA, Chan CW, Reynolds HG, Tsang S, et al. Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation. 2006;113(23):2733–43. doi:10.​1161/​CIRCULATIONAHA.​105.​570648.PubMedCrossRef
33.
go back to reference Wu E, Ortiz JT, Tejedor P, Lee DC, Bucciarelli-Ducci C, Kansal P, et al. Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart. 2008;94(6):730–6. doi:10.1136/hrt.2007.122622.PubMedCrossRef Wu E, Ortiz JT, Tejedor P, Lee DC, Bucciarelli-Ducci C, Kansal P, et al. Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart. 2008;94(6):730–6. doi:10.​1136/​hrt.​2007.​122622.PubMedCrossRef
34.
go back to reference Klein C, Nekolla SG, Balbach T, Schnackenburg B, Nagel E, Fleck E, et al. The influence of myocardial blood flow and volume of distribution on late Gd-DTPA kinetics in ischemic heart failure. J Magn Reson Imaging. 2004;20(4):588–93. doi:10.1002/jmri.20164.PubMedCrossRef Klein C, Nekolla SG, Balbach T, Schnackenburg B, Nagel E, Fleck E, et al. The influence of myocardial blood flow and volume of distribution on late Gd-DTPA kinetics in ischemic heart failure. J Magn Reson Imaging. 2004;20(4):588–93. doi:10.​1002/​jmri.​20164.PubMedCrossRef
35.
go back to reference Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003;361(9355):374–9. doi:10.1016/s0140-6736(03)12389-6.PubMedCrossRef Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003;361(9355):374–9. doi:10.​1016/​s0140-6736(03)12389-6.PubMedCrossRef
36.
go back to reference Mahrholdt H, Wagner A, Holly TA, Elliott MD, Bonow RO, Kim RJ, et al. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation. 2002;106(18):2322–7.PubMedCrossRef Mahrholdt H, Wagner A, Holly TA, Elliott MD, Bonow RO, Kim RJ, et al. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation. 2002;106(18):2322–7.PubMedCrossRef
37.
go back to reference Kim RJ, Albert TS, Wible JH, Elliott MD, Allen JC, Lee JC, et al. Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction: an international, multicenter, double-blinded, randomized trial. Circulation. 2008;117(5):629–37. doi:10.1161/CIRCULATIONAHA.107.723262.PubMedCrossRef Kim RJ, Albert TS, Wible JH, Elliott MD, Allen JC, Lee JC, et al. Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction: an international, multicenter, double-blinded, randomized trial. Circulation. 2008;117(5):629–37. doi:10.​1161/​CIRCULATIONAHA.​107.​723262.PubMedCrossRef
38.
go back to reference Choudhury L, Mahrholdt H, Wagner A, Choi KM, Elliott MD, Klocke FJ, et al. Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2002;40(12):2156–64.PubMedCrossRef Choudhury L, Mahrholdt H, Wagner A, Choi KM, Elliott MD, Klocke FJ, et al. Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2002;40(12):2156–64.PubMedCrossRef
42.
44.
go back to reference Becker AE, Heijmans CD, Essed CE. Chronic non-ischaemic congestive heart disease and endomyocardial biopsies. Worth the extra? Eur Heart J. 1991;12(2):218–23.PubMed Becker AE, Heijmans CD, Essed CE. Chronic non-ischaemic congestive heart disease and endomyocardial biopsies. Worth the extra? Eur Heart J. 1991;12(2):218–23.PubMed
45.
go back to reference Kehr E, Sono M, Chugh SS, Jerosch-Herold M. Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro. Int J Cardiovasc Imaging. 2008;24(1):61–8. doi:10.1007/s10554-007-9223-y.PubMedCrossRef Kehr E, Sono M, Chugh SS, Jerosch-Herold M. Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro. Int J Cardiovasc Imaging. 2008;24(1):61–8. doi:10.​1007/​s10554-007-9223-y.PubMedCrossRef
46.••
go back to reference Flett AS, Hayward MP, Ashworth MT, Hansen MS, Taylor AM, Elliott PM, et al. Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation. 2010;122(2):138–44. doi:10.1161/CIRCULATIONAHA.109.930636. The authors developed an extracellular volume technique and validated it against histology in patients with severe aortic stenosis and hypertrophic cardiomyopathy.PubMedCrossRef Flett AS, Hayward MP, Ashworth MT, Hansen MS, Taylor AM, Elliott PM, et al. Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation. 2010;122(2):138–44. doi:10.​1161/​CIRCULATIONAHA.​109.​930636. The authors developed an extracellular volume technique and validated it against histology in patients with severe aortic stenosis and hypertrophic cardiomyopathy.PubMedCrossRef
47.
go back to reference White SK, Sado DM, Fontana M, Banypersad SM, Maestrini V, Flett AS, et al. T1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique. JACC Cardiovasc Imaging. 2013. doi:10.1016/j.jcmg.2013.01.011. White SK, Sado DM, Fontana M, Banypersad SM, Maestrini V, Flett AS, et al. T1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique. JACC Cardiovasc Imaging. 2013. doi:10.​1016/​j.​jcmg.​2013.​01.​011.
48.
go back to reference Miller CA, Naish JH, Bishop P, Coutts G, Clark D, Zhao S, et al. Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. Circ Cardiovasc Imaging. 2013;6(3):373–83. doi:10.1161/CIRCIMAGING.112.000192.PubMedCrossRef Miller CA, Naish JH, Bishop P, Coutts G, Clark D, Zhao S, et al. Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. Circ Cardiovasc Imaging. 2013;6(3):373–83. doi:10.​1161/​CIRCIMAGING.​112.​000192.PubMedCrossRef
49.
go back to reference Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol. 2008;52(19):1574–80. doi:10.1016/j.jacc.2008.06.049.PubMedCrossRef Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol. 2008;52(19):1574–80. doi:10.​1016/​j.​jacc.​2008.​06.​049.PubMedCrossRef
50.
go back to reference Coelho-Filho OR, Shah RV, Mitchell R, Neilan TG, Moreno Jr H, Simonson B, et al. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. 2013;128(11):1225–33. doi:10.1161/CIRCULATIONAHA.112.000438.PubMed Coelho-Filho OR, Shah RV, Mitchell R, Neilan TG, Moreno Jr H, Simonson B, et al. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. 2013;128(11):1225–33. doi:10.​1161/​CIRCULATIONAHA.​112.​000438.PubMed
51.••
go back to reference Ugander M, Oki AJ, Hsu LY, Kellman P, Greiser A, Aletras AH, et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur Heart J. 2012;33(10):1268–78. doi:10.1093/eurheartj/ehr481. The authors show that ECV imaging can quantitatively characterize MI, atypical diffuse fibrosis, and subtle myocardial abnormalities not clinically apparent on LGE images.PubMedCrossRef Ugander M, Oki AJ, Hsu LY, Kellman P, Greiser A, Aletras AH, et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur Heart J. 2012;33(10):1268–78. doi:10.​1093/​eurheartj/​ehr481. The authors show that ECV imaging can quantitatively characterize MI, atypical diffuse fibrosis, and subtle myocardial abnormalities not clinically apparent on LGE images.PubMedCrossRef
52.••
go back to reference Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012;126(10):1206–16. doi:10.1161/CIRCULATIONAHA.111.089409. In this large cohort study, the authors show in unselected patients that ECV predicts outcomes at least as strongly as left ventricular ejection fraction.PubMedCentralPubMedCrossRef Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012;126(10):1206–16. doi:10.​1161/​CIRCULATIONAHA.​111.​089409. In this large cohort study, the authors show in unselected patients that ECV predicts outcomes at least as strongly as left ventricular ejection fraction.PubMedCentralPubMedCrossRef
53.
go back to reference Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, et al. Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. Eur Heart J. 2013. doi:10.1093/eurheartj/eht193. Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, et al. Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. Eur Heart J. 2013. doi:10.​1093/​eurheartj/​eht193.
54.•
go back to reference Piechnik SK, Ferreira VM, Dall'Armellina E, Cochlin LE, Greiser A, Neubauer S, et al. Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson. 2010;12:69. doi:10.1186/1532-429X-12-69. A seminal papers for the three main T1 mapping sequences.PubMedCrossRef Piechnik SK, Ferreira VM, Dall'Armellina E, Cochlin LE, Greiser A, Neubauer S, et al. Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson. 2010;12:69. doi:10.​1186/​1532-429X-12-69. A seminal papers for the three main T1 mapping sequences.PubMedCrossRef
55.•
go back to reference Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med. 2004;52(1):141–6. doi:10.1002/mrm.20110. A seminal paper for the three main T1 mapping sequences. Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med. 2004;52(1):141–6. doi:10.​1002/​mrm.​20110. A seminal paper for the three main T1 mapping sequences.
56.•
go back to reference Chow K, Flewitt JA, Green JD, Pagano JJ, Friedrich MG, Thompson RB. Saturation recovery single-shot acquisition (SASHA) for myocardial T mapping. Magn Reson Med. 2013. doi:10.1002/mrm.24878. A seminal paper for the three main T1 mapping sequences. Chow K, Flewitt JA, Green JD, Pagano JJ, Friedrich MG, Thompson RB. Saturation recovery single-shot acquisition (SASHA) for myocardial T mapping. Magn Reson Med. 2013. doi:10.​1002/​mrm.​24878. A seminal paper for the three main T1 mapping sequences.
57.••
go back to reference Kellman P, Wilson JR, Xue H, Ugander M, Arai AE. Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method. J Cardiovasc Magn Reson. 2012;14:63. doi:10.1186/1532-429X-14-63. In this work, the authors developed and evaluated a fully automated, motion-corrected and co-registered method for producing ECV maps feasible for clinical work flow.PubMedCrossRef Kellman P, Wilson JR, Xue H, Ugander M, Arai AE. Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method. J Cardiovasc Magn Reson. 2012;14:63. doi:10.​1186/​1532-429X-14-63. In this work, the authors developed and evaluated a fully automated, motion-corrected and co-registered method for producing ECV maps feasible for clinical work flow.PubMedCrossRef
58.
60.
go back to reference Sado DM, White SK, Piechnik SK, Banypersad SM, Treibel T, Captur G, et al. The identification and assessment of anderson fabry disease by cardiovascular magnetic resonance non-contrast myocardial T1 mapping. Circ Cardiovasc Imaging. 2013. doi:10.1161/CIRCIMAGING.112.000070. Sado DM, White SK, Piechnik SK, Banypersad SM, Treibel T, Captur G, et al. The identification and assessment of anderson fabry disease by cardiovascular magnetic resonance non-contrast myocardial T1 mapping. Circ Cardiovasc Imaging. 2013. doi:10.​1161/​CIRCIMAGING.​112.​000070.
62.
63.
go back to reference Ferreira VM, Piechnik SK, Dall'armellina E, Karamitsos TD, Francis JM, Ntusi N, et al. T mapping for the diagnosis of acute myocarditis using CMR: comparison to T-weighted and late gadolinium enhanced imaging. JACC Cardiovasc Imaging. 2013. doi:10.1016/j.jcmg.2013.03.008. Ferreira VM, Piechnik SK, Dall'armellina E, Karamitsos TD, Francis JM, Ntusi N, et al. T mapping for the diagnosis of acute myocarditis using CMR: comparison to T-weighted and late gadolinium enhanced imaging. JACC Cardiovasc Imaging. 2013. doi:10.​1016/​j.​jcmg.​2013.​03.​008.
64.••
go back to reference Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson. 2013;15(1):92. doi:10.1186/1532-429X-15-92. This document provides recommendations for clinical and research T1 and ECV measurement, addressing site preparation, scan type, scan planning and acquisition, quality control, visualisation and analysis, technical development, as well as discussing controversies in the field.PubMedCrossRef Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson. 2013;15(1):92. doi:10.​1186/​1532-429X-15-92. This document provides recommendations for clinical and research T1 and ECV measurement, addressing site preparation, scan type, scan planning and acquisition, quality control, visualisation and analysis, technical development, as well as discussing controversies in the field.PubMedCrossRef
65.
go back to reference Robson MD, Piechnik SK, Tunnicliffe EM, Neubauer S. T measurements in the human myocardium: the effects of magnetization transfer on the SASHA and MOLLI sequences. Magn Reson Med. 2013. doi:10.1002/mrm.24867. Robson MD, Piechnik SK, Tunnicliffe EM, Neubauer S. T measurements in the human myocardium: the effects of magnetization transfer on the SASHA and MOLLI sequences. Magn Reson Med. 2013. doi:10.​1002/​mrm.​24867.
68.
go back to reference Ugander MC, Chen MY, Chen B, Bagi PS, Hsu LY, Kellman P, Arai AE. Contrast Enhanced CT and MRI Measures of Extracellular Volume Fraction Confirm Presence of Peri-Infarct Edema in Acute Myocardial Infarction (Abstract). American Heart Association 2011. Ugander MC, Chen MY, Chen B, Bagi PS, Hsu LY, Kellman P, Arai AE. Contrast Enhanced CT and MRI Measures of Extracellular Volume Fraction Confirm Presence of Peri-Infarct Edema in Acute Myocardial Infarction (Abstract). American Heart Association 2011.
69.
go back to reference Bandula S, White SK, Flett AS, Lawrence D, Pugliese F, Ashworth MT, et al. Measurement of myocardial extracellular volume fraction by using equilibrium contrast-enhanced CT: validation against histologic findings. Radiology. 2013. doi:10.1148/radiol.13130130. Bandula S, White SK, Flett AS, Lawrence D, Pugliese F, Ashworth MT, et al. Measurement of myocardial extracellular volume fraction by using equilibrium contrast-enhanced CT: validation against histologic findings. Radiology. 2013. doi:10.​1148/​radiol.​13130130.
70.
go back to reference Nacif MS, Kawel N, Lee JJ, Chen X, Yao J, Zavodni A, et al. Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. Radiology. 2012;264(3):876–83. doi:10.1148/radiol.12112458.PubMedCrossRef Nacif MS, Kawel N, Lee JJ, Chen X, Yao J, Zavodni A, et al. Interstitial myocardial fibrosis assessed as extracellular volume fraction with low-radiation-dose cardiac CT. Radiology. 2012;264(3):876–83. doi:10.​1148/​radiol.​12112458.PubMedCrossRef
Metadata
Title
Myocardial Tissue Characterization: Histological and Pathophysiological Correlation
Authors
T. A. Treibel
S. K. White
J. C. Moon
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Cardiovascular Imaging Reports / Issue 3/2014
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-013-9254-9

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