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Published in: Current Cardiovascular Imaging Reports 3/2014

01-03-2014 | Cardiac Nuclear Imaging (A Cuocolo Section Editor)

Nuclear Cardiology in Heart Failure

Authors: Selene Capitanio, Cecilia Marini, Matteo Bauckneht, Gianmario Sambuceti

Published in: Current Cardiovascular Imaging Reports | Issue 3/2014

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Abstract

Despite recent advances in drug and non-pharmacological treatments, heart failure represents a serious public health problem that is steadily increasing in developed countries. A deeper comprehension of mechanisms underlying this condition still remains the only way to decrease morbidity and mortality in these patients. To this purpose, integrated information on heart failure etiology and pathophysiology is needed for an accurate prediction of patient outcome. Among the currently available non-invasive imaging techniques, nuclear medicine has a peculiar role due to its capability to simultaneously evaluate different aspects of disease and to provide insights into the molecular and cellular mechanisms involved in progression of left ventricular dysfunction. This review aims to synthetically describe possibilities and problems in the radionuclide evaluation of myocardial function, perfusion, innervation and molecular pathways underlying heart failure progression and its complications.
Literature
2.
go back to reference Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, et al. Heart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation. 2011;123:18–209.CrossRef Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, et al. Heart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation. 2011;123:18–209.CrossRef
3.
go back to reference Maddox DE, Wynne J, Uren R, et al. Regional ejection fraction: a quantative radionuclide index of regional left ventricular performance. Circulation. 1979;59:1001–9.PubMedCrossRef Maddox DE, Wynne J, Uren R, et al. Regional ejection fraction: a quantative radionuclide index of regional left ventricular performance. Circulation. 1979;59:1001–9.PubMedCrossRef
4.
go back to reference Hesse B, Lindhardt TB, Acampa W, et al. EANM/ESC guidelines for radionuclide imaging of cardiac function. Eur J Nucl Med Mol Imaging. 2008;35:851–85.PubMedCrossRef Hesse B, Lindhardt TB, Acampa W, et al. EANM/ESC guidelines for radionuclide imaging of cardiac function. Eur J Nucl Med Mol Imaging. 2008;35:851–85.PubMedCrossRef
5.
go back to reference Jessup M, Abraham WT, Casey DE, et al. 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:1977–2016.PubMedCrossRef Jessup M, Abraham WT, Casey DE, et al. 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:1977–2016.PubMedCrossRef
6.
go back to reference Neglia D, Parodi O, Marzullo P, Sambuceti G, et al. Behavior of right and left ventricles during episodes of variant angina in relation to the site of coronary vasospasm. Circulation. 1990;81:567–77.PubMedCrossRef Neglia D, Parodi O, Marzullo P, Sambuceti G, et al. Behavior of right and left ventricles during episodes of variant angina in relation to the site of coronary vasospasm. Circulation. 1990;81:567–77.PubMedCrossRef
7.•
go back to reference Mitra D, Basu S. Equilibrium radionuclide angiocardiography: its usefulness in current practice and potential future applications. World J Radiol. 2012;28(4):421–30. A current review and analysis of an old technique with still a large clinical potential..CrossRef Mitra D, Basu S. Equilibrium radionuclide angiocardiography: its usefulness in current practice and potential future applications. World J Radiol. 2012;28(4):421–30. A current review and analysis of an old technique with still a large clinical potential..CrossRef
8.
go back to reference Abidov A, Hachamovitch R, Berman DS. Modern nuclear cardiac imaging in diagnosis and clinical management of patients with left ventricular dysfunction. Minerva Cardioangiol. 2004;52:505–19.PubMed Abidov A, Hachamovitch R, Berman DS. Modern nuclear cardiac imaging in diagnosis and clinical management of patients with left ventricular dysfunction. Minerva Cardioangiol. 2004;52:505–19.PubMed
9.
go back to reference Sharir T, Germano G, Kang X, et al. Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction. J Nucl Med. 2001;42:831–7.PubMed Sharir T, Germano G, Kang X, et al. Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction. J Nucl Med. 2001;42:831–7.PubMed
10.
go back to reference Kasama S, Toyama T, Kumakura H, et al. Dobutamine stress 99mTc-tetrofosmin quantitative gated SPECT predicts improvement of cardiac function after carvedilol treatment in patients with dilated cardiomyopathy. J Nucl Med. 2004;45:1878–84.PubMed Kasama S, Toyama T, Kumakura H, et al. Dobutamine stress 99mTc-tetrofosmin quantitative gated SPECT predicts improvement of cardiac function after carvedilol treatment in patients with dilated cardiomyopathy. J Nucl Med. 2004;45:1878–84.PubMed
11.
go back to reference Gheorghiade M, Sopko G, De Luca L, et al. Navigating the croassroads of coronary artery disease and heart failure. Circulation. 2006;114:1012–3.CrossRef Gheorghiade M, Sopko G, De Luca L, et al. Navigating the croassroads of coronary artery disease and heart failure. Circulation. 2006;114:1012–3.CrossRef
12.
go back to reference Smith Jr SC, Blair SN. AHA/ACC Scientific Statement: AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation. 2001;104:1577–9.PubMedCrossRef Smith Jr SC, Blair SN. AHA/ACC Scientific Statement: AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation. 2001;104:1577–9.PubMedCrossRef
13.
go back to reference Felker GM, Thompson RE, Hare JM, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med. 2000;342:1077–84.PubMedCrossRef Felker GM, Thompson RE, Hare JM, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med. 2000;342:1077–84.PubMedCrossRef
14.
15.
go back to reference Udelson JE, Shafer CD, Carrio I. Radionuclide imaging in heart failure: assessing etiology and outcomes and implications for management. J Nucl Cardiol. 2002;9:40–52.CrossRef Udelson JE, Shafer CD, Carrio I. Radionuclide imaging in heart failure: assessing etiology and outcomes and implications for management. J Nucl Cardiol. 2002;9:40–52.CrossRef
16.
go back to reference Nitszche EU, Choi Y, Czernin J, et al. Noninvasive quantification of myocardial blood flow in humans. A direct comparison of the [13N]ammonia and the [15O]water techniques. Circulation. 1996;93:2000–6.CrossRef Nitszche EU, Choi Y, Czernin J, et al. Noninvasive quantification of myocardial blood flow in humans. A direct comparison of the [13N]ammonia and the [15O]water techniques. Circulation. 1996;93:2000–6.CrossRef
17.
go back to reference El FG, Kardan A, Sitek A, et al. Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PET. J Nucl Med. 2009;50:1062–71.CrossRef El FG, Kardan A, Sitek A, et al. Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PET. J Nucl Med. 2009;50:1062–71.CrossRef
18.
go back to reference Neglia D, Parodi O, Gallopin M, et al. Myocardial blood flow response to pacing tachycardia and to dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitative assessment by positron emission tomography. Circulation. 1995;92:796–804.PubMedCrossRef Neglia D, Parodi O, Gallopin M, et al. Myocardial blood flow response to pacing tachycardia and to dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitative assessment by positron emission tomography. Circulation. 1995;92:796–804.PubMedCrossRef
19.
go back to reference Neglia D, Michelassi C, Trivieri MG, et al. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation. 2002;105:186–93.PubMedCrossRef Neglia D, Michelassi C, Trivieri MG, et al. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation. 2002;105:186–93.PubMedCrossRef
20.
go back to reference Schinkel AF, Bax JJ, Poldermans D, et al. Hibernating myocardium: diagnosis and patient outcomes. Curr Probl Cardiol. 2007;32:375–410.PubMedCrossRef Schinkel AF, Bax JJ, Poldermans D, et al. Hibernating myocardium: diagnosis and patient outcomes. Curr Probl Cardiol. 2007;32:375–410.PubMedCrossRef
21.
go back to reference Tillisch J, Brunken R, Marshall R, et al. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med. 1986;314:884–8.PubMedCrossRef Tillisch J, Brunken R, Marshall R, et al. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med. 1986;314:884–8.PubMedCrossRef
22.
go back to reference Camici PG, Prasad SK, Rimoldi OE. Stunning, hibernation, and assessment of myocardial viability. Circulation. 2008;117:103–14.PubMedCrossRef Camici PG, Prasad SK, Rimoldi OE. Stunning, hibernation, and assessment of myocardial viability. Circulation. 2008;117:103–14.PubMedCrossRef
23.
go back to reference Pagano D, Lewis ME, Townend JN, et al. Coronary revascularization for postischaemic heart failure: how myocardial viability affects survival. Heart. 1999;82:684–8.PubMed Pagano D, Lewis ME, Townend JN, et al. Coronary revascularization for postischaemic heart failure: how myocardial viability affects survival. Heart. 1999;82:684–8.PubMed
24.
go back to reference Sambuceti G, Giorgetti A, Corsiglia L, et al. Perfusion-contraction mismatch during inotropic stimulation in hibernating myocardium. J Nucl Med. 1998;39:396–402.PubMed Sambuceti G, Giorgetti A, Corsiglia L, et al. Perfusion-contraction mismatch during inotropic stimulation in hibernating myocardium. J Nucl Med. 1998;39:396–402.PubMed
26.
go back to reference Ghostine S, Caussin C, Habis M, et al. Non-invasive diagnosis of ischaemic heart failure using 64-slice computed tomography. Eur Heart J. 2008;29:2133–40.PubMedCrossRef Ghostine S, Caussin C, Habis M, et al. Non-invasive diagnosis of ischaemic heart failure using 64-slice computed tomography. Eur Heart J. 2008;29:2133–40.PubMedCrossRef
27.•
go back to reference Ko BS, Cameron JD, Meredith IT, et al. Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: a comparison with fractional flow reserve. Eur Heart J. 2012;33:67–77. This work documented the additional value of computed tomography myocardial perfusion imaging used with computed tomography coronary angiography to detect ischemia..PubMedCrossRef Ko BS, Cameron JD, Meredith IT, et al. Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: a comparison with fractional flow reserve. Eur Heart J. 2012;33:67–77. This work documented the additional value of computed tomography myocardial perfusion imaging used with computed tomography coronary angiography to detect ischemia..PubMedCrossRef
28.•
go back to reference Bamberg F, Becker A, Schwarz F, et al. Detection of hemodynamically significant coronary artery stenosis: incremental diagnostic value of dynamic CT-based myocardial perfusion imaging. Radiology. 2011;260:689–98. This study conducted on 36 patients, showed the diagnostic accuracy of CT in the detection of coronary artery stenosis in association with a hemodinamically significant reduction of myocardial blood flow..PubMedCrossRef Bamberg F, Becker A, Schwarz F, et al. Detection of hemodynamically significant coronary artery stenosis: incremental diagnostic value of dynamic CT-based myocardial perfusion imaging. Radiology. 2011;260:689–98. This study conducted on 36 patients, showed the diagnostic accuracy of CT in the detection of coronary artery stenosis in association with a hemodinamically significant reduction of myocardial blood flow..PubMedCrossRef
29.•
go back to reference Hulten EA, Bittencourt MS, Ghoshhajra B, et al. Stress CT perfusion: coupling coronary anatomy with physiology. J Nucl Cardiol. 2012;19:588–600. In this review the authors underlined the strengths and the limitations of CT in the evaluation of coronary anatomy and myocardial perfusion..PubMedCrossRef Hulten EA, Bittencourt MS, Ghoshhajra B, et al. Stress CT perfusion: coupling coronary anatomy with physiology. J Nucl Cardiol. 2012;19:588–600. In this review the authors underlined the strengths and the limitations of CT in the evaluation of coronary anatomy and myocardial perfusion..PubMedCrossRef
30.
go back to reference Bauer RW, Kerl JM, Fischer N, et al. Dual-energy CT for the assessment of chronic myocardial infarction in patients with chronic coronary artery disease: comparison with 3-T MRI. AJR Am J Roentgenol. 2010;196:W550–7. Bauer RW, Kerl JM, Fischer N, et al. Dual-energy CT for the assessment of chronic myocardial infarction in patients with chronic coronary artery disease: comparison with 3-T MRI. AJR Am J Roentgenol. 2010;196:W550–7.
31.
go back to reference Sambuceti G, Marini C, Morbelli S, et al. Witnessing ischemia or proofing coronary atherosclerosis: two different windows on the same or on different pathways precipitating cardiovascular events? J Nucl Cardiol. 2009;16:447–55.PubMedCrossRef Sambuceti G, Marini C, Morbelli S, et al. Witnessing ischemia or proofing coronary atherosclerosis: two different windows on the same or on different pathways precipitating cardiovascular events? J Nucl Cardiol. 2009;16:447–55.PubMedCrossRef
32.
go back to reference Packer M, Coats AJ, Fowler MB, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344:1651–8.PubMedCrossRef Packer M, Coats AJ, Fowler MB, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344:1651–8.PubMedCrossRef
33.
go back to reference Cohn J, Levine T, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with congestive heart failure. N Engl J Med. 1984;311:819–82.PubMedCrossRef Cohn J, Levine T, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with congestive heart failure. N Engl J Med. 1984;311:819–82.PubMedCrossRef
34.
go back to reference Engelhardt S, Hein L, Wiesmann F, et al. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci U S A. 1999;96:7059–64.PubMedCentralPubMedCrossRef Engelhardt S, Hein L, Wiesmann F, et al. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci U S A. 1999;96:7059–64.PubMedCentralPubMedCrossRef
35.
go back to reference Freeman K, Lerman I, Kranias EG, et al. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J Clin Invest. 2001;107:967–74.PubMedCentralPubMedCrossRef Freeman K, Lerman I, Kranias EG, et al. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J Clin Invest. 2001;107:967–74.PubMedCentralPubMedCrossRef
36.
go back to reference Eisenhofer G, Friberg P, Rundqvist B, et al. Cardiac sympathetic nerve function in congestive heart failure. Circulation. 1996;93:1667–76.PubMedCrossRef Eisenhofer G, Friberg P, Rundqvist B, et al. Cardiac sympathetic nerve function in congestive heart failure. Circulation. 1996;93:1667–76.PubMedCrossRef
37.
go back to reference Hattori N, Schwaiger M. Metaiodobenzylguanidine scintigraphy of the heart: what have we learnt clinically? Eur J Nucl Med. 2000;27:1–6.PubMedCrossRef Hattori N, Schwaiger M. Metaiodobenzylguanidine scintigraphy of the heart: what have we learnt clinically? Eur J Nucl Med. 2000;27:1–6.PubMedCrossRef
38.
go back to reference Carrió I, Cowie MR, Yamazaki J, et al. Cardiac sympathetic imaging with MIBG in heart failure. JACC Cardiovasc Imaging. 2010;3:92–100.PubMedCrossRef Carrió I, Cowie MR, Yamazaki J, et al. Cardiac sympathetic imaging with MIBG in heart failure. JACC Cardiovasc Imaging. 2010;3:92–100.PubMedCrossRef
39.
go back to reference Jacobson AF, Senior R, Cerqueira MD, et al. Myocardial iodine-123 meta- iodobenzylguanidine imaging and cardiac events in heart failure: results of the prospective ADMIRE-HF study. J Am Coll Cardiol. 2010;55:2212–21.PubMedCrossRef Jacobson AF, Senior R, Cerqueira MD, et al. Myocardial iodine-123 meta- iodobenzylguanidine imaging and cardiac events in heart failure: results of the prospective ADMIRE-HF study. J Am Coll Cardiol. 2010;55:2212–21.PubMedCrossRef
40.
go back to reference Nishisato K, Hashimoto A, Nakata T, et al. Impaired cardiac sympathetic innervation and myocardial perfusion are related to lethal arrhythmia: quantification of cardiac tracers in patients with ICDs. J Nucl Med. 2010;51:1241–9.PubMedCrossRef Nishisato K, Hashimoto A, Nakata T, et al. Impaired cardiac sympathetic innervation and myocardial perfusion are related to lethal arrhythmia: quantification of cardiac tracers in patients with ICDs. J Nucl Med. 2010;51:1241–9.PubMedCrossRef
41.
go back to reference Tamaki S, Yamada T, Okuyama Y, Morita T, Sanada S, Tsukamoto Y, et al. Cardiac iodine-123 Metaiodobenzylguanidine imaging predicts sudden cardiac death independently of left ventricular ejection fraction in patients with chronic heart failure and left ventricular systolic dysfunction: results from a comparative study with signal averaged electrocardiogram, heart rate variability, and QT dispersion. J Am Coll Cardiol. 2009;53:426–35.PubMedCrossRef Tamaki S, Yamada T, Okuyama Y, Morita T, Sanada S, Tsukamoto Y, et al. Cardiac iodine-123 Metaiodobenzylguanidine imaging predicts sudden cardiac death independently of left ventricular ejection fraction in patients with chronic heart failure and left ventricular systolic dysfunction: results from a comparative study with signal averaged electrocardiogram, heart rate variability, and QT dispersion. J Am Coll Cardiol. 2009;53:426–35.PubMedCrossRef
42.
go back to reference Boogers MJ, Borleffs CJ, Henneman MM, et al. Cardiac sympathetic denervation assessed with 123-Iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients. J Am Coll Cardiol. 2010;55:2769–77.PubMedCrossRef Boogers MJ, Borleffs CJ, Henneman MM, et al. Cardiac sympathetic denervation assessed with 123-Iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients. J Am Coll Cardiol. 2010;55:2769–77.PubMedCrossRef
43.
go back to reference Marini C, Giorgetti A, Gimelli A, et al. Extension of myocardial necrosis differently affects MIBG retention in heart failure caused by ischaemic heart disease or by dilated cardiomyopathy. Eur J Nucl Med Mol Imaging. 2005;32:682–8.PubMedCrossRef Marini C, Giorgetti A, Gimelli A, et al. Extension of myocardial necrosis differently affects MIBG retention in heart failure caused by ischaemic heart disease or by dilated cardiomyopathy. Eur J Nucl Med Mol Imaging. 2005;32:682–8.PubMedCrossRef
44.
45.
go back to reference Su H, Spinale FG, Dobrucki LW, et al. Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation. 2005;112:3157–67.PubMedCrossRef Su H, Spinale FG, Dobrucki LW, et al. Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation. 2005;112:3157–67.PubMedCrossRef
46.
go back to reference Boersma HH, Kietselaer BLJH, Stolk LML, et al. Past, present, and future of annexin A5: from protein discovery to clinical applications. J Nucl Med. 2005;46:2035–50.PubMed Boersma HH, Kietselaer BLJH, Stolk LML, et al. Past, present, and future of annexin A5: from protein discovery to clinical applications. J Nucl Med. 2005;46:2035–50.PubMed
47.
go back to reference Lefebvre F, Prefontaine A, Calderone A, et al. Modification of the pulmonary renin-angiotensin system and lung structural remodelling in congestive heart failure. Clin Sci (Lond). 2006;111:217–24.CrossRef Lefebvre F, Prefontaine A, Calderone A, et al. Modification of the pulmonary renin-angiotensin system and lung structural remodelling in congestive heart failure. Clin Sci (Lond). 2006;111:217–24.CrossRef
48.
go back to reference Asano Y, Ihn H, Yamane K, et al. Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. J Immunol. 2005;175:7708–18.PubMed Asano Y, Ihn H, Yamane K, et al. Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. J Immunol. 2005;175:7708–18.PubMed
49.
go back to reference Spinale FG. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev. 2007;87:1285–342.PubMedCrossRef Spinale FG. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev. 2007;87:1285–342.PubMedCrossRef
50.
go back to reference Wilson EM, Moainie SL, Baskin JM, et al. Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation. 2003;107:2857–63.PubMedCrossRef Wilson EM, Moainie SL, Baskin JM, et al. Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation. 2003;107:2857–63.PubMedCrossRef
51.
go back to reference Assomull RG, Prasad SK, Lyne J, et al. Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol. 2006;48:1977–85.PubMedCrossRef Assomull RG, Prasad SK, Lyne J, et al. Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol. 2006;48:1977–85.PubMedCrossRef
52.
go back to reference Poulsen SH, Host NB, Jensen SE, et al. Relationship between serum amino-terminal propeptide of type III procollagen and changes of left ventricular function after acute myocardial infarction. Circulation. 2000;101:1527–32.PubMedCrossRef Poulsen SH, Host NB, Jensen SE, et al. Relationship between serum amino-terminal propeptide of type III procollagen and changes of left ventricular function after acute myocardial infarction. Circulation. 2000;101:1527–32.PubMedCrossRef
53.
go back to reference Van den Borne SWM, Isobe S, Zandbergen HR, et al. Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling. J Am Coll Cardiol Img. 2009;2:187–98.CrossRef Van den Borne SWM, Isobe S, Zandbergen HR, et al. Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling. J Am Coll Cardiol Img. 2009;2:187–98.CrossRef
54.
go back to reference Verjans JW, Lovhaug D, Narula N, et al. Noninvasive imaging of angiotensin receptors after myocardial infarction. JACC Cardiovasc Imaging. 2008;1:354–62.PubMedCentralPubMedCrossRef Verjans JW, Lovhaug D, Narula N, et al. Noninvasive imaging of angiotensin receptors after myocardial infarction. JACC Cardiovasc Imaging. 2008;1:354–62.PubMedCentralPubMedCrossRef
55.
go back to reference Mann DL. Molecular Imaging and the failing heart. J Am Coll Cardiol Img. 2009;2:199–201.CrossRef Mann DL. Molecular Imaging and the failing heart. J Am Coll Cardiol Img. 2009;2:199–201.CrossRef
Metadata
Title
Nuclear Cardiology in Heart Failure
Authors
Selene Capitanio
Cecilia Marini
Matteo Bauckneht
Gianmario Sambuceti
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Cardiovascular Imaging Reports / Issue 3/2014
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-013-9256-7

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