Top

Published in:

Open Access 01-01-2014 | Heart Failure and Targeted Imaging (T Schindler and E Schelbert, Section Editors)

Imaging of Myocardial Oxidative Metabolism in Heart Failure

Authors: Masanao Naya, Nagara Tamaki

Published in: Current Cardiovascular Imaging Reports | Issue 1/2014

Abstract

Metabolic imaging has a potential for better understanding of pathophysiology of heart failure. C-11 acetate is taken up by the heart, rapidly converted to acetylCoA and readily metabolized to C-11 CO₂ through TCA cycle with oxidative phosphorylation. Thus, the myocardial turnover rate of this tracer is tightly correlated with its clearance of C-11 CO₂, reflecting overall oxidative metabolism. The heart relies on aerobic oxidative substrate for the generation of ATP, which is required to maintain its contractile function. The progression to heart failure is associated with a gradual decline in the activity of mitochondrial respiratory pathways, leading to diminished capacity for ATP production. The work metabolic index can also be estimated by the combination of C-11 acetate PET and hemodynamics by echocardiography, the metabolic index is a significant marker to understand the pathophysiology of heart failure as well as myocardial oxidative metabolism.

Pike VW et al. Preparation of [1–11C]acetate–an agent for the study of myocardial metabolism by positron emission tomography. Int J Appl Radiat Isot. 1982;33(7):505–12.PubMedCrossRef

Brown M et al. Delineation of myocardial oxygen utilization with carbon-11-labeled acetate. Circulation. 1987;76(3):687–96.PubMedCrossRef

Buxton DB et al. Radiolabeled acetate as a tracer of myocardial tricarboxylic acid cycle flux. Circ Res. 1988;63(3):628–34.PubMedCrossRef

Brown MA, Myears DW, Bergmann SR. Validity of estimates of myocardial oxidative metabolism with carbon-11 acetate and positron emission tomography despite altered patterns of substrate utilization. J Nucl Med. 1989;30(2):187–93.PubMed

Tamaki N et al. Myocardial oxidative metabolism in normal subjects in fasting, glucose loading and dobutamine infusion states. Ann Nucl Med. 1992;6(4):221–8.PubMedCrossRef

Armbrecht JJ, Buxton DB, Schelbert HR. Validation of [1-11C]acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic, and hyperemic canine myocardium. Circulation. 1990;81(5):1594–605.PubMedCrossRef

Buxton DB et al. Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C]acetate and dynamic positron emission tomography. Circulation. 1989;79(1):134–42.PubMedCrossRef

Buxton DB et al. Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium. Circulation. 1992;85(5):1842–56.PubMedCrossRef

Hashimoto T et al. Responses of blood flow, oxygen consumption, and contractile function to inotropic stimulation in stunned canine myocardium. Am Heart J. 1994;127(5):1250–62.PubMedCrossRef

10.

Heyndrickx GR et al. Recovery of regional contractile function and oxidative metabolism in stunned myocardium induced by 1-hour circumflex coronary artery stenosis in chronically instrumented dogs. Circ Res. 1993;72(4):901–13.PubMedCrossRef

11.

Beanlands RS et al. Acute effects of dobutamine on myocardial oxygen consumption and cardiac efficiency measured using carbon-11 acetate kinetics in patients with dilated cardiomyopathy. J Am Coll Cardiol. 1993;22(5):1389–98.PubMedCrossRef

12.

Beanlands RS et al. The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy. J Nucl Cardiol. 1994;1(1):3–16.PubMedCrossRef

13.

Bengel FM et al. Myocardial efficiency and sympathetic reinnervation after orthotopic heart transplantation: a noninvasive study with positron emission tomography. Circulation. 2001;103(14):1881–6.PubMedCrossRef

14.

Walsh MN et al. Noninvasive estimation of regional myocardial oxygen consumption by positron emission tomography with carbon-11 acetate in patients with myocardial infarction. J Nucl Med. 1989;30(11):1798–808.PubMed

15.

Henes CG et al. The Time Course of Restoration of Nutritive Perfusion, Myocardial Oxygen-Consumption, and Regional Function after Coronary Thrombolysis. Coronary Artery Disease. 1990;1(6):687–96.CrossRef

16.

Kalff V et al. Use of C-11 Acetate and Dynamic Positron Emission Tomography to Assess Regional Myocardial Oxygen-Consumption in Patients with Acute Myocardial-Infarction Receiving Thrombolysis or Coronary Angioplasty. American Journal of Cardiology. 1993;71(7):529–35.PubMedCrossRef

17.

Czernin J et al. Regional Blood-Flow, Oxidative-Metabolism, and Glucose-Utilization in Patients with Recent Myocardial-Infarction. Circulation. 1993;88(3):884–95.PubMedCrossRef

18.

Vanoverschelde JL et al. Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium Circulation. 1993;87(5):1513–23.

19.

Gropler RJ et al. Dependence of recovery of contractile function on maintenance of oxidative metabolism after myocardial infarction. J Am Coll Cardiol. 1992;19(5):989–97.PubMedCrossRef

20.

Gropler RJ et al. Functional recovery after coronary revascularization for chronic coronary artery disease is dependent on maintenance of oxidative metabolism. J Am Coll Cardiol. 1992;20(3):569–77.PubMedCrossRef

21.

Weinheimer CJ et al. Functional recovery after reperfusion is predicated on recovery of myocardial oxidative metabolism. Am Heart J. 1993;125(4):939–49.PubMedCrossRef

22.

Hicks RJ et al. Metabolic imaging by positron emission tomography early after myocardial infarction as a predictor of recovery of myocardial function after reperfusion. J Nucl Cardiol. 1994;1(2 Pt 1):124–37.PubMedCrossRef

23.

Chan SY et al. Use of the Metabolic Tracer Carbon-11-Acetate for Evaluation of Regional Myocardial Perfusion. Journal of Nuclear Medicine. 1991;32(4):665–72.PubMed

24.

Gropler RJ, Siegel BA, Geltman EM. Myocardial uptake of carbon-11-acetate as an indirect estimate of regional myocardial blood flow. J Nucl Med. 1991;32(2):245–51.PubMed

25.

Wolpers HG et al. Assessment of myocardial viability by use of ¹¹C-acetate and positron emission tomography. Threshold criteria of reversible dysfunction Circulation. 1997;95(6):1417–24.

26.

Gropler RJ et al. Comparison of carbon-11-acetate with fluorine-18-fluorodeoxyglucose for delineating viable myocardium by positron emission tomography. J Am Coll Cardiol. 1993;22(6):1587–97.PubMedCrossRef

27.

Rubin PJ et al. Superiority of C-11 acetate compared with F-18 fluorodeoxyglucose in predicting myocardial functional recovery by positron emission tomography in patients with acute myocardial infarction. American Journal of Cardiology. 1996;78(11):1230–5.PubMedCrossRef

28.

Vanoverschelde JL et al. Regional oxidative metabolism in patients after recovery from reperfused anterior myocardial infarction. Relation to regional blood flow and glucose uptake Circulation. 1992;85(1):9–21.

29.

Henes CG et al. Assessment of myocardial oxidative metabolic reserve with positron emission tomography and carbon-11 acetate. J Nucl Med. 1989;30(9):1489–99.PubMed

30.

Hata T et al. Noninvasive assessment of myocardial viability by positron emission tomography with 11C acetate in patients with old myocardial infarction. Usefulness of low-dose dobutamine infusion Circulation. 1996;94(8):1834–41.

31.

Yoshinaga K et al. Reduced oxidative metabolic response in dysfunctional myocardium with preserved glucose metabolism but with impaired contractile reserve. J Nucl Med. 2004;45(11):1885–91.PubMed

32.

Huss JM, Kelly DP. Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest. 2005;115(3):547–55.PubMedCentralPubMed

33.

Tadamura E et al. Myocardial metabolic changes in hypertrophic cardiomyopathy. J Nucl Med. 1996;37(4):572–7.PubMed

34.

Bach DS et al. Heterogeneity of ventricular function and myocardial oxidative metabolism in nonischemic dilated cardiomyopathy. J Am Coll Cardiol. 1995;25(6):1258–62.PubMedCrossRef

35.

Wu YW et al. Heterogeneous reduction of myocardial oxidative metabolism in patients with ischemic and dilated cardiomyopathy using C-11 acetate PET. Circ J. 2008;72(5):786–92.PubMedCrossRef

36.

Hicks RJ et al. Assessment of myocardial oxidative metabolism in aortic valve disease using positron emission tomography with C-11 acetate. Am Heart J. 1992;123(3):653–64.PubMedCrossRef

37.••

Naya M et al. Myocardial oxidative metabolism is increased due to haemodynamic overload in patients with aortic valve stenosis: assessment using ¹¹C-acetate positron emission tomography. Eur J Nucl Med Mol Imaging. 2010;37(12):2242–8. This paper shows an increase in oxidative metabolism in patients with aortic stenosis with its reduction after operation, indicating such an increase in oxidative metabolism in AS largely attributable to the LV pressire overload. (The most important recent report from our group.).PubMedCrossRef

38.

Bing RJ, Hammond MM, et al. The measurement of coronary blood flow, oxygen consumption, and efficiency of the left ventricle in man. Am Heart J. 1949;38(1):1–24.PubMedCrossRef

39.

Stolen KQ et al. Exercise training improves biventricular oxidative metabolism and left ventricular efficiency in patients with dilated cardiomyopathy. J Am Coll Cardiol. 2003;41(3):460–7.PubMedCrossRef

40.

Christenson SD et al. Effects of simultaneous and optimized sequential cardiac resynchronization therapy on myocardial oxidative metabolism and efficiency. J Cardiovasc Electrophysiol. 2008;19(2):125–32.PubMedCrossRef

41.

Ukkonen H et al. Effect of cardiac resynchronization on myocardial efficiency and regional oxidative metabolism. Circulation. 2003;107(1):28–31.PubMedCrossRef

42.

Matsui Y et al. Integrated overlapping ventriculoplasty combined with papillary muscle plication for severely dilated heart failure. J Thorac Cardiovasc Surg. 2004;127(4):1221–3.PubMedCrossRef

43.••

Sugiki T et al. Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency in nonischemic and ischemic dilated cardiomyopathy. JACC Cardiovasc Imaging. 2011;4(7):762–70. This paper nicely shows an imporvement of cardiac efficiency in association with reduced LV volume after surgical ventricular reconstruction and mitral complex reconstruction in patients with severe heart failure. This paper is also received an editorial comments from Dr Robert Bonow. (The most important recent report from our group.).PubMedCrossRef

44.

Chow BJ et al. Effects of mitral valve surgery on myocardial energetics in patients with severe mitral regurgitation. Circ Cardiovasc Imaging. 2010;3(3):308–13.PubMedCrossRef

45.

Hicks RJ et al. Assessment of right ventricular oxidative metabolism by positron emission tomography with C-11 acetate in aortic valve disease. Am J Cardiol. 1991;67(8):753–7.PubMedCrossRef

46.•

Wong YY et al. ¹¹C-Acetate clearance as an index of oxygen consumption of the right myocardium in idiopathic pulmonary arterial hypertension: a validation study using 15O-labeled tracers and PET. J Nucl Med. 2013;54(8):1258–62. This is the first report to analyze oxidative metabolism in the right ventricle using PET in patients with idiopathic pulmonary hypertension. (The important recent report from another group.).PubMedCrossRef

Title: Imaging of Myocardial Oxidative Metabolism in Heart Failure
Authors: Masanao Naya
Nagara Tamaki
Publication date: 01-01-2014
Publisher: Springer US
Published in: Current Cardiovascular Imaging Reports / Issue 1/2014
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-013-9244-y

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Imaging of Myocardial Oxidative Metabolism in Heart Failure

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2014

Imaging of Cardiac Autonomic Innervation with SPECT and PET

Recent Developments in Imaging of Myocardial Angiotensin Receptors

What You See is What You Get? Imaging of Cell Therapy for Cardiac Regeneration

Myocardial Blood Flow Quantification from MRI – an Image Analysis Perspective

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page