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01-01-2014 | Molecular Imaging (G Strijkers, Section Editor)

Myocardial Blood Flow Quantification from MRI – an Image Analysis Perspective

Authors: Niloufar Zarinabad, Amedeo Chiribiri, Marcel Breeuwer

Published in: Current Cardiovascular Imaging Reports | Issue 1/2014

Abstract

First-pass perfusion imaging allows for a very high spatial resolution, noninvasive and radiation free quantification of myocardial blood flow. True quantification of perfusion images offers a unique capability to localize and measure subendocardial ischemia. Several techniques such as semiquantitative, model independent and model dependent methods are available for calculating MBF from perfusion CMR. However, for accurate perfusion quantification a few requirements need to be addressed beforehand. These include but are not limited to the relationship between the amount of injected contrast agent and the signal intensity of the MR image, used pulse sequence, and the extraction of an arterial input function. Moreover, with the new advances in CMR perfusion imaging, high spatial resolution voxel-wise quantitative analysis of myocardial perfusion is feasible. Voxel-wise quantification has the potential to combine the advantage of visual analysis with the objective and reproducible evaluation made by true quantitative methods.

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Zarinabad N, Hautvast G, Breeuwer M, Nagel E, Chiribiri A, editors. The relationship between spatial resolution levels and quantitative myocardial perfusion. Society of Cardiovascular Magnetic Resonance; San Francisco; 2013. J Cardiovasc Magn Reson. This study evaluates the effects of spatial resolution level on the accuracy of the perfusion estimates.

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Jerosch-Herold M, Coelho-Filho OR. Do we need a new prescription to view myocardial perfusion? JACC Cardiovasc Imaging. 2012;5:167–8. doi:10.1016/j.jcmg.2011.08.022. This editorial comments on the voxel-wise analysis of myocardial perfusion.PubMedCrossRef

Title: Myocardial Blood Flow Quantification from MRI – an Image Analysis Perspective
Authors: Niloufar Zarinabad
Amedeo Chiribiri
Marcel Breeuwer
Publication date: 01-01-2014
Publisher: Springer US
Published in: Current Cardiovascular Imaging Reports / Issue 1/2014
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-013-9246-9

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