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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 3/2014

01-06-2014 | Original Article

Computer-aided diagnosis system outperforms scoring analysis in myocardial perfusion imaging

Authors: Lena Johansson, BMSc, Lars Edenbrandt, MD, PhD, Kenichi Nakajima, MD, PhD, Milan Lomsky, MD, PhD, Sven-Eric Svensson, MD, PhD, Elin Trägårdh, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 3/2014

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Abstract

Background

The aim of this myocardial perfusion imaging (MPI) study was to compare the diagnostic performance of two computer-aided diagnosis (CAD) systems, EXINI HeartTM (EXINI), and PERFEXTM (PERFEX) Emory Cardiac Toolbox (ECT), and the summed stress score (SSS) values from both software packages.

Methods

We studied 1,052 consecutive patients who underwent 2-day stress/rest 99mTc-sestamibi MPI studies. The reference standard classifications for the MPI studies were obtained from three experienced physicians who separately classified all cases regarding the presence or absence of ischemia and/or infarction. Automatic processing was carried out using EXINI and PERFEX to obtain CAD results and SSS values based on the 17-segment model.

Results

The three experts’ classifications showed ischemia in 257 patients and abnormal studies, i.e., either ischemia or infarction or both, in 318 patients. Accuracy was significantly higher in EXINI than in PERFEX, regarding both the detection of ischemia (87.4 vs 77.6%; P < 0.0001) and the detection of abnormal studies (91.6 vs 67.9%; P < 0.0001). EXINI’s CAD system showed a higher specificity than its SSS values (86.8 vs 73.6%; P < 0.0001) at the same level of sensitivity.

Conclusions

EXINI demonstrated greater diagnostic accuracy for detection of ischemia and abnormal studies than did PERFEX. EXINI CAD also outperformed its SSS analysis.
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Metadata
Title
Computer-aided diagnosis system outperforms scoring analysis in myocardial perfusion imaging
Authors
Lena Johansson, BMSc
Lars Edenbrandt, MD, PhD
Kenichi Nakajima, MD, PhD
Milan Lomsky, MD, PhD
Sven-Eric Svensson, MD, PhD
Elin Trägårdh, MD, PhD
Publication date
01-06-2014
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 3/2014
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-013-9815-y

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