Top

Published in:

01-06-2019 | Retrovirus | Original Article

Human endogenous retrovirus, HERV-P and HERV-R in pediatric leukemia patients

Authors: Massimiliano Bergallo, Katia Mareschi, Paola Montanari, Cristina Calvi, Massimo Berger, Ilaria Bini, Valentina Daprà, Ilaria Galliano, Franca Fagioli

Published in: Journal of Hematopathology | Issue 2/2019

Abstract

The “HERVs” (human endogenous retroviruses) are a family of endogenous retroviruses integrated into the germ cell DNA of primate over than 30 million years ago. HERV expression seems impaired in several diseases, ranging from autoimmune to neoplastic disorders. The purpose of this study was to evaluate the overall endogenous retroviral transcription profile in bone marrow (BM) samples. A total of 30 pediatric lymphoid and myeloid malignancies patients were tested. Our findings show that HERV-R expression results significantly higher in leukemia patients than donors. This overexpression might be related to lymphatic leukemogenesis and it warrants further investigations.

Sverdlov ED (2000) Retroviruses and primate evolution. Bioessays 22:161–171CrossRefPubMed

Bannert N, Kurth R (2006) The evolutionary dynamics of human endogenous retroviral families. Annu Rev Genomics Hum Genet 7:149–173CrossRefPubMed

Subramanian R, Wildschutte J, Russo C et al (2011) Identification, characterization, and comparative genomic distribution of the HERV-K(HML-2) group of human endogenous retroviruses. Retrovirology 8:90CrossRefPubMedPubMedCentral

Gotzinger N, Sauter M, Roemer K et al (1996) Regulation of human endogenous retrovirus-K gag expression in teratocarcinoma cell lines and human tumours. J Gen Virol 77:2983–2990CrossRefPubMed

Katoh I, Kurata SI (2013) Association of endogenous retroviruses and long terminal repeats with human disorders. Front Oncol 3:234CrossRefPubMedPubMedCentral

Hohn O, Hanke K, Bannert N (2013) HERV-K (HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease. Front Oncol 3:246CrossRefPubMedPubMedCentral

Ruprecht K, Mayer J, Sauter M et al (2008) Endogenous retroviruses and cancer. Cell Mol Life Sci 6(5):3366–3382CrossRef

Weiss RA (2006) The discovery of endogenous retroviruses. Retrovirology 3:67CrossRefPubMedPubMedCentral

Depil S, Roche C, Dussart P, Prin L (2002) Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients. Leukemia 16:254–259CrossRefPubMed

10.

Iwabuchi H, Kakihara T, Kobayashi T, Imai C, Tanaka A, Uchiyama M, Fakuda T (2004) A gene homologous to human endogenous retrovirus overexpressed in childhood acute lymphoblastic leukemia. Leuk Lymphoma 45:2303–2306CrossRefPubMed

11.

Januszkiewicz-Lewandowska D, Nowicka K, Rembowska J, Fichna M, Żurawek M, Derwich K, Nowak J (2013) Env gene expression of human endogenous retrovirus-K and human endogenous retrovirus-W in childhood acute leukemia cells. Acta Haematol 129:232–237. https://doi.org/10.1159/000345407 CrossRefPubMed

12.

Bergallo M, Montanari P, Mareschi K, Merlino C, Berger M, Bini I, Daprà V, Galliano I, Fagioli F (2017) Expression of the pol gene of human endogenous retroviruses HERV-K and -W in leukemia patients. Arch Virol 162(12):3639–3644. https://doi.org/10.1007/s00705-017-3526-7 CrossRefPubMed

13.

Ahn K, Kim HS (2009) Structural and quantitative expression analyses of HERV gene in human tissues. Mol Cell 28:99–103CrossRef

14.

Yi JM, Kim HM, Kim HS (2004) Expression of the human endogenous retrovirus HERV-W family in various human tissues and cancer cells. J Gen Virol 85:1203–1210CrossRefPubMed

15.

Fischer S, Echeverría N, Moratorio G, Landoni AI, Dighiero G, Cristina J, Oppezzo P, Moreno P (2014) Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients. Leuk Res Rep 25:70–72. https://doi.org/10.1016/j.lrr.2014.06.005 CrossRef

16.

Andersson AC, Venables PJ, Tonjes RR, Scherer J, Eriksson L, Larsson E (2002) Developmental expression of HERV-R (ERV3) and HERV-K in human tissue. Virology 297:220–225CrossRefPubMed

17.

Antony JM, Ellestad KK, Hammond R et al (2007) The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes. J Immunol 179:1210–1224CrossRefPubMed

18.

Dulmage BO, Feng H, Mirvish E et al (2015) Black cat in a dark room: absence of a directly oncogenic virus does not eliminate the role of an infectious agent in CTCL pathogenesis. Br J Dermatol 172:1449–1451CrossRefPubMedPubMedCentral

19.

Herbst H, Sauter M, Mueller-Lantzsch N (1996) Expression of human endogenousretrovirus K elements in germ cell and trophoblastic tumors. Am J Pathol 149:1727–1735PubMedPubMedCentral

20.

Herbst H, Sauter M, Kühler-Obbarius C et al (1998) Human endogenous retrovirus (HERV)-K transcripts in germ cell and trophoblastic tumours. APMIS 106:216–220CrossRefPubMed

21.

Herbst H, Kühler-Obbarius C, Lauke H et al (1999) Human endogenous retrovirus (HERV)-K transcripts in gonadoblastomas and gonadoblastoma-derived germ cell tumours. Virchows Arch 434:11–15CrossRefPubMed

22.

Benešová M, Trejbalová K, Kovářová D et al (2017) DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas. Retrovirology 14(20). https://doi.org/10.1186/s12977-017-0342-9

23.

Rhyu DW, Kang YJ, Ock MS et al (2014) Expression of human endogenous retrovirus env genes in the blood of breast cancer patients. Int J Mol Sci 15:9173–9183. https://doi.org/10.3390/ijms15069173 CrossRefPubMedPubMedCentral

24.

Goering W, Schmitt K, Dostert M et al (2015) Human endogenous retrovirus HERV-K(HML-2) activity in prostate cancer is dominated by a few loci. Prostate 75:1958–1971. https://doi.org/10.1002/pros.23095 CrossRefPubMed

25.

Maliniemi P, Vincendeau M, Mayer J et al (2013) Expression of human endogenous retrovirus-w including syncytin-1 in cutaneous T-cell lymphoma. PLoS One 8(10):e76281. https://doi.org/10.1371/journal.pone.0076281 CrossRefPubMedPubMedCentral

26.

Fava P, Bergallo M, Astrua C et al (2016) Human endogenous retrovirus expression in primary cutaneous T-cell lymphomas. Dermatology 232:38–43. https://doi.org/10.1159/000438669 CrossRefPubMed

27.

Wentzensen N, Wilz B, Findeisen P et al (2004) Identification of differentially expressed genes in colorectal adenoma compared to normal tissue by suppression subtractive hybridization. Int J Oncol 24:987–994PubMed

28.

Liang Q, Xu Z, Xu R et al (2012) Expression patterns of non-coding spliced transcripts from human endogenous retrovirus HERV-H elements in colon cancer. PLoS One 7:e29950. https://doi.org/10.1371/journal.pone.0029950 CrossRefPubMedPubMedCentral

29.

Giebler M, Staege MS, Blauschmidt S et al (2018) Elevated HERV-K expression in soft tissue sarcoma is associated with worsened relapse-free survival. Front Microbiol 9:211. https://doi.org/10.3389/fmicb.2018.00211 CrossRefPubMedPubMedCentral

30.

Ma W, Hong Z, Liu H et al (2016) Human endogenous retroviruses-K (HML-2) expression is correlated with prognosis and progress of hepatocellular carcinoma. Biomed Res Int 2016:8201642. https://doi.org/10.1155/2016/8201642 CrossRefPubMedPubMedCentral

31.

Li M, Radvanyi L, Yin B et al (2017) Downregulation of human endogenous retrovirus type K (HERV-K) viral env RNA in pancreatic cancer cells decreases cell proliferation and tumor growth. Clin Cancer Res 23:5892–5911. https://doi.org/10.1158/1078-0432.CCR-17-0001 CrossRefPubMedPubMedCentral

32.

Boeke JD, Stoye JP (1997) Retrotransposons, endogenous retroviruses, and the evolution of retroelements. In: Coffin JM, Hughes SH, Varmus HE (eds) Retroviruses. Cold Spring Harbour Laboratory Press, New York, pp 343–435

33.

Sandoval J, Esteller M (2012) Cancer epigenomics: beyond genomics. Curr Opin Genet Dev 22:50–55. https://doi.org/10.1016/j.gde.2012.02.008 CrossRefPubMed

34.

Stengel S, Fiebig U, Kurth R et al (2010) Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation. Genes Chromosom Cancer 49(5):401–411. https://doi.org/10.1002/gcc.20751 CrossRefPubMed

35.

Kreimer U, Schulz WA, Koch A et al (2013) HERV-K and LINE-1 DNA methylation and reexpression in urothelial carcinoma. Front Oncol 3:255. https://doi.org/10.3389/fonc.2013.00255 CrossRefPubMedPubMedCentral

36.

Romanish MT, Cohen CJ, Mager DL (2010) Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer. Semin Cancer Biol 20:246–253. https://doi.org/10.1016/j.semcancer.2010.05.005 CrossRefPubMed

37.

Huang G, Li Z, Wan X et al (2013) Human endogenous retroviral K element encodes fusogenic activity in melanoma cells. J Carcinog 12. https://doi.org/10.4103/1477-3163.109032

38.

Strick R, Ackermann S, Langbein M, Swiatek J et al (2007) Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral syncytin-1 and regulated by TGF-beta. J Mol Med 85:23–38. https://doi.org/10.1007/s00109-006-0104-y CrossRefPubMed

39.

Bjerregaard B, Holck S, Christensen IJ et al (2006) Syncytin is involved in breast cancer-endothelial cell fusions. Cell Mol Life Sci 63:1906–1911. https://doi.org/10.1007/s00018-006-6201-9 CrossRefPubMed

40.

Mangeney M, de Parseval N, Thomas G et al (2001) The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties. J Gen Virol 82:2515–2518. https://doi.org/10.1099/0022-1317-82-10-2515 CrossRefPubMed

41.

Kudo-Saito C, Yura M, Yamamoto R et al (2014) Induction of immunoregulatory CD271+ cells by metastatic tumor cells that express human endogenous retrovirus H. Cancer Res 74:1361–1370. https://doi.org/10.1158/0008-5472.CAN-13-1349 CrossRefPubMed

42.

Matteucci C, Balestrieri E, Argaw-Denboba A et al (2018) Human endogenous retroviruses role in cancer cell stemness. Semin Cancer Biol 53:17–30. https://doi.org/10.1016/j.semcancer.2018.10.001 CrossRefPubMed

Title: Human endogenous retrovirus, HERV-P and HERV-R in pediatric leukemia patients
Authors: Massimiliano Bergallo
Katia Mareschi
Paola Montanari
Cristina Calvi
Massimo Berger
Ilaria Bini
Valentina Daprà
Ilaria Galliano
Franca Fagioli
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Keywords: Retrovirus
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Chronic Myeloid Leukemia
Leukemia
Published in: Journal of Hematopathology / Issue 2/2019
Print ISSN: 1868-9256
Electronic ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-019-00352-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Human endogenous retrovirus, HERV-P and HERV-R in pediatric leukemia patients

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2019

Comparison of clinical diagnoses and autopsy findings in 54 cases with lymphoid neoplasms

Biclonal splenic marginal zone lymphoma with T cell-rich background and aggressive transformation to large cell lymphoma

Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia

Characterization of a t(1;2)(p36;p21) involving the PRDM16 gene region by mate-pair sequencing (MPseq) in a patient with newly diagnosed acute myeloid leukemia with myelodysplasia-related changes

Advancing diagnostic hematopathology: pigeons or pixels?

Leishmania interaction with an osteoclast