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Journal of Cardiovascular Translational Research

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01-08-2019 | Heart Failure | Original Article

A Novel Wireless Left Atrial Pressure Monitoring System for Patients with Heart Failure, First Ex-Vivo and Animal Experience

Authors: Leor Perl, Elina Soifer, Jozef Bartunek, Dedi Erdheim, Friedrich Köhler, William T. Abraham, David Meerkin

Published in: Journal of Cardiovascular Translational Research | Issue 4/2019

Abstract

The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts were compared with pulmonary capillary wedge pressure (PCWP) at index procedure and 1, 2 and 3–6 months after the implantation, at rest and after volume loading. Histopathology assessment (n = 8) was performed up to 50 weeks post procedure. Procedural success was 100%. Measurements showed a mean difference of 0.19 ± 2.51 mmHg. During this period, correlation of V-LAP™ with PCWP was excellent (R² = 0.95, for 119 total measurements). There were no major adverse events related to the V-LAP™ system. In an animal model, the implantation of the novel wireless left atrial pressure sensor V-LAP™ was feasible, safe, and showed good accuracy and precision.

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Title: A Novel Wireless Left Atrial Pressure Monitoring System for Patients with Heart Failure, First Ex-Vivo and Animal Experience
Authors: Leor Perl
Elina Soifer
Jozef Bartunek
Dedi Erdheim
Friedrich Köhler
William T. Abraham
David Meerkin
Publication date: 01-08-2019
Publisher: Springer US
Keyword: Heart Failure
Published in: Journal of Cardiovascular Translational Research / Issue 4/2019
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-018-9856-3

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