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Journal of Cardiovascular Translational Research
Published in: Journal of Cardiovascular Translational Research 1/2011

Open Access 01-02-2011

Direct Left Atrial Pressure Monitoring in Severe Heart Failure: Long-Term Sensor Performance

Authors: Richard W. Troughton, Jay Ritzema, Neal L. Eigler, Iain C. Melton, Henry Krum, Philip B. Adamson, Saibal Kar, Prediman K. Shah, James S. Whiting, J. Thomas Heywood, Spencer Rosero, Jagmeet P. Singh, Leslie Saxon, Ray Matthews, Ian G. Crozier, William T. Abraham, the HOMEOSTASIS Investigators

Published in: Journal of Cardiovascular Translational Research | Issue 1/2011

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Abstract

We report the stability, accuracy, and development history of a new left atrial pressure (LAP) sensing system in ambulatory heart failure (HF) patients. A total of 84 patients with advanced HF underwent percutaneous transseptal implantation of the pressure sensor. Quarterly noninvasive calibration by modified Valsalva maneuver was achieved in all patients, and 96.5% of calibration sessions were successful with a reproducibility of 1.2 mmHg. Absolute sensor drift was maximal after 3 months at 4.7 mmHg (95% CI, 3.2–6.2 mmHg) and remained stable through 48 months. LAP was highly correlated with simultaneous pulmonary wedge pressure at 3 and 12 months (r = 0.98, average difference of 0.8 ± 4.0 mmHg). Freedom from device failure was 95% (n = 37) at 2 years and 88% (n = 12) at 4 years. Causes of failure were identified and mitigated with 100% freedom from device failure and less severe anomalies in the last 41 consecutive patients (p = 0.005). Accurate and reliable LAP measurement using a chronic implanted monitoring system is safe and feasible in patients with advanced heart failure.
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Metadata
Title
Direct Left Atrial Pressure Monitoring in Severe Heart Failure: Long-Term Sensor Performance
Authors
Richard W. Troughton
Jay Ritzema
Neal L. Eigler
Iain C. Melton
Henry Krum
Philip B. Adamson
Saibal Kar
Prediman K. Shah
James S. Whiting
J. Thomas Heywood
Spencer Rosero
Jagmeet P. Singh
Leslie Saxon
Ray Matthews
Ian G. Crozier
William T. Abraham
the HOMEOSTASIS Investigators
Publication date
01-02-2011
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 1/2011
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-010-9229-z

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