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Journal of Cardiovascular Translational Research

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Open Access 01-06-2019 | Original Article

Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output

Authors: Jenny Seilitz, Tal M. Hörer, Per Skoog, Mitra Sadeghi, Kjell Jansson, Birger Axelsson, Kristofer F. Nilsson

Published in: Journal of Cardiovascular Translational Research | Issue 3/2019

Abstract

The impact of acute cardiac dysfunction on the gastrointestinal tract was investigated in anesthetized and instrumented pigs by sequential reductions of cardiac output (CO). Using a cardiac tamponade (n = 6) or partial inferior caval vein balloon inflation (n = 6), CO was controllably reduced for 1 h each to 75% (CO_75%), 50% (CO_50%), and 35% (CO_35%) of the baseline value. Cardiac output in controls (n = 6) was not manipulated and maintained. Mean arterial pressure, superior mesenteric arterial blood flow, and intestinal mucosal perfusion started to decrease at CO_50% in the intervention groups. The decrease in superior mesenteric arterial blood flow was non-linear and exaggerated at CO_35%. Systemic, venous mesenteric, and intraperitoneal lactate concentrations increased in the intervention groups from CO_50%. Global and mesenteric oxygen uptake decreased at CO_35%. In conclusion, gastrointestinal metabolism became increasingly anaerobic when CO was reduced by 50%. Anaerobic gastrointestinal metabolism in low CO can be detected using intraperitoneal microdialysis.

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Title: Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output
Authors: Jenny Seilitz
Tal M. Hörer
Per Skoog
Mitra Sadeghi
Kjell Jansson
Birger Axelsson
Kristofer F. Nilsson
Publication date: 01-06-2019
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 3/2019
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-018-9845-6

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Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output

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