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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 5/2022

01-05-2022 | Original Article

Voxel-based analysis of age and gender effects on striatal [123I] FP-CIT binding in healthy Japanese adults

Authors: Yoko Shigemoto, Hiroshi Matsuda, Yukio Kimura, Emiko Chiba, Masahiro Ohnishi, Moto Nakaya, Norihide Maikusa, Masayo Ogawa, Yohei Mukai, Yuji Takahashi, Kazuya Sako, Hiroshi Toyama, Yoshitaka Inui, Yasuyuki Taki, Hiroshi Nagayama, Kenjiro Ono, Atsushi Kono, Kenji Sekiguchi, Shigeki Hirano, Noriko Sato

Published in: Annals of Nuclear Medicine | Issue 5/2022

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Abstract

Objective

Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [(123)I] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)I] FP-CIT)-single photon emission computed tomography (SPECT) scans in 256 healthy Japanese adults.

Methods

We used the Southampton method to calculate the specific binding ratios (SBRs) of each subject’s striatum and then converted the [123I] FP-CIT SPECT images to quantitative SBRs images. To investigate the effects of age and gender effects on striatal DaT binding, we performed a voxel-based analysis using statistical parametric mapping. Gender differences were also compared between young to middle-aged subjects and elderly subjects (age threshold: 60 years).

Results

When all subjects were explored as a group, DaT binding throughout the striatum decreased with advancing age. Among all subjects, the females showed higher DaT binding in the bilateral caudate compared to the males. In the young to middle-aged subjects, the females showed higher DaT binding throughout the striatum (with a slight caudate predominance) versus the males. In the elderly, there were no gender differences in striatal DaT binding.

Conclusion

Our findings of striatal subregional age- and gender-related differences may provide useful information to construct a more detailed DaT database in healthy Japanese subjects.
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Metadata
Title
Voxel-based analysis of age and gender effects on striatal [123I] FP-CIT binding in healthy Japanese adults
Authors
Yoko Shigemoto
Hiroshi Matsuda
Yukio Kimura
Emiko Chiba
Masahiro Ohnishi
Moto Nakaya
Norihide Maikusa
Masayo Ogawa
Yohei Mukai
Yuji Takahashi
Kazuya Sako
Hiroshi Toyama
Yoshitaka Inui
Yasuyuki Taki
Hiroshi Nagayama
Kenjiro Ono
Atsushi Kono
Kenji Sekiguchi
Shigeki Hirano
Noriko Sato
Publication date
01-05-2022
Publisher
Springer Nature Singapore
Published in
Annals of Nuclear Medicine / Issue 5/2022
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-022-01725-9

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