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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 4/2022

01-04-2022 | Computed Tomography | Original Article

Correlation between noise pareidolia test scores for visual hallucinations and regional cerebral blood flow in dementia with Lewy bodies

Authors: Takashi Nakata, Kenichi Shimada, Akiko Iba, Haruhiko Oda, Akira Terashima, Yutaka Koide, Ryota Kawasaki, Takahiro Yamada, Kazunari Ishii

Published in: Annals of Nuclear Medicine | Issue 4/2022

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Abstract

Objective

This study aimed at investigating the correlation between recurrent visual hallucinations (VHs) and regional cerebral blood flow (rCBF) in patients with dementia with Lewy bodies (DLB).

Methods

In 147 DLB patients, the correlation between noise pareidolia scores and rCBF in brain perfusion single photon emission computed tomography (SPECT) was evaluated. The 147 subjects comprised 52 probable and 95 possible DLB patients, of whom 107 did not have visual hallucinations and 40 had visual hallucinations. Brain perfusion SPECT was then performed, and memory impairment was assessed using the Mini-Mental State Examination (MMSE), while the optical illusion “pareidolia” (the tendency to see a specific image in a random visual pattern) was evaluated using noise pareidolia test. The correlations between rCBF and MMSE or noise pareidolia scores were then analyzed.

Results

The rCBF and MMSE scores were positively correlated, and rCBF was correlated with MMSE scores in a region that was consistent with a previously reported memory-related site. There was no correlation between noise pareidolia scores and occipital CBF, but there were weak correlations between noise pareidolia scores and rCBF in the bilateral frontal lobes (Brodmann area [BA]8 and BA9), left cingulate cortex (BA31), and left angular and supramarginal gyri (BA39 and BA40) in DLB patients.

Conclusion

Weak correlation was found between noise pareidolia scores and rCBF in several sites (BA8, BA9, BA31, BA39 and BA40) other than in occipital lobe. These findings suggest that DLB hallucinations may be manifested by more complex brain network disorders, rather than by primary visual cortex disorders alone.
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Metadata
Title
Correlation between noise pareidolia test scores for visual hallucinations and regional cerebral blood flow in dementia with Lewy bodies
Authors
Takashi Nakata
Kenichi Shimada
Akiko Iba
Haruhiko Oda
Akira Terashima
Yutaka Koide
Ryota Kawasaki
Takahiro Yamada
Kazunari Ishii
Publication date
01-04-2022
Publisher
Springer Singapore
Published in
Annals of Nuclear Medicine / Issue 4/2022
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-022-01717-9

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