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01-08-2017 | Original Article

Effect of resolution recovery using graph plots on regional cerebral blood flow in healthy volunteers

Authors: Nobuhiro Yada, Hideo Onishi, Masahiro Miyai, Kentarou Ozasa, Takashi Katsube, Keiichi Onoda, Masuo Haramoto, Yasushi Yamamoto, Shuhei Yamaguchi, Hajime Kitagaki

Published in: Annals of Nuclear Medicine | Issue 7/2017

Abstract

Purpose

We evaluated the effect of resolution recovery (RR) using graph plots on regional cerebral blood flow (rCBF) in brain perfusion single-photon emission computed tomography (SPECT) images derived from healthy volunteers and patients diagnosed with probable Alzheimer’s disease.

Method

We acquired brain perfusion SPECT images with scatter correction (SC), computed tomography-based attenuation correction (CTAC), and RR from a three-dimensional brain phantom and from healthy volunteers. We then compared contrast-to-noise ratio, count density ratios, increase maps, and rCBF using statistical parametric mapping 8.

Results

Regional brain counts were significantly increased from 20–24% with SC, CTAC, and RR compared with SC and CTAC. Mean CBF in healthy volunteers was 42.5 ± 5.4 mL/100 g/min. Average rCBF determined using SC, CTAC and RR increased 7.5, 2.0, and 3.7% at the thalamus, posterior cingulate, and whole brain, respectively, compared with SC and CTAC.

Conclusion

Resolution recovery caused variations in normal rCBF because counts increased in cerebral regions.

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Title: Effect of resolution recovery using graph plots on regional cerebral blood flow in healthy volunteers
Authors: Nobuhiro Yada
Hideo Onishi
Masahiro Miyai
Kentarou Ozasa
Takashi Katsube
Keiichi Onoda
Masuo Haramoto
Yasushi Yamamoto
Shuhei Yamaguchi
Hajime Kitagaki
Publication date: 01-08-2017
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 7/2017
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-017-1186-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effect of resolution recovery using graph plots on regional cerebral blood flow in healthy volunteers

Abstract

Purpose

Method

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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