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01-05-2011 | Original Article

Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT

Authors: Kazunari Ishii, Takafumi Uemura, Naokazu Miyamoto, Toshiki Yoshikawa, Toshiaki Yamaguchi, Tatsuhiko Ashihara, Yukihiro Ohtani

Published in: Annals of Nuclear Medicine | Issue 4/2011

Abstract

Purpose

The graph plot method, a technique that uses N-isopropyl-¹²³I-p-iodoamphetamine (IMP) and single photon emission computed tomography (SPECT) for non-invasive measurement of regional cerebral blood flow (CBF), has been developed and applied in the clinical setting, although it has been performed without obtaining normal CBF values in normal, healthy subjects. The aim of this study was to measure normal regional CBF in older healthy subjects with IMP SPECT and the graph plot method.

Subjects and methods

Eleven healthy volunteers (mean age: 63.5 ± 8.9 years; six males and five females) were recruited and regional CBF was measured using IMP SPECT and the graph plot method.

Results

The averaged global CBF was 45.4 ml/100 g/min. The distribution of regional CBF was almost homogenous in the cortices. There was no significant correlation between the global CBF and age in subjects aged 50–80 years.

Conclusion

We used the IMP graph plot method to measure regional CBF in normal healthy subjects, without arterial blood sampling, and obtained compatible CBF values. This method is non-invasive and convenient for determination of regional CBF in the clinical setting.

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Title: Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT
Authors: Kazunari Ishii
Takafumi Uemura
Naokazu Miyamoto
Toshiki Yoshikawa
Toshiaki Yamaguchi
Tatsuhiko Ashihara
Yukihiro Ohtani
Publication date: 01-05-2011
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 4/2011
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-010-0451-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT

Abstract

Purpose

Subjects and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Subjects and methods

Results

Conclusion

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