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Hepatology International
Published in: Hepatology International 1/2021

Open Access 01-02-2021 | Esophageal Varices | Review Article

Regression of portal hypertension: underlying mechanisms and therapeutic strategies

Authors: Sonia Selicean, Cong Wang, Sergi Guixé-Muntet, Horia Stefanescu, Norifumi Kawada, Jordi Gracia-Sancho

Published in: Hepatology International | Issue 1/2021

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Abstract

Portal hypertension is the main non-neoplastic complication of chronic liver disease, being the cause of important life-threatening events including the development of ascites or variceal bleeding. The primary factor in the development of portal hypertension is a pathological increase in the intrahepatic vascular resistance, due to liver microcirculatory dysfunction, which is subsequently aggravated by extra-hepatic vascular disturbances including elevation of portal blood inflow. Evidence from pre-clinical models of cirrhosis has demonstrated that portal hypertension and chronic liver disease can be reversible if the injurious etiological agent is removed and can be further promoted using pharmacological therapy. These important observations have been partially demonstrated in clinical studies. This paper aims at providing an updated review of the currently available data regarding spontaneous and drug-promoted regression of portal hypertension, paying special attention to the clinical evidence. It also considers pathophysiological caveats that highlight the need for caution in establishing a new dogma that human chronic liver disease and portal hypertension is reversible.
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Metadata
Title
Regression of portal hypertension: underlying mechanisms and therapeutic strategies
Authors
Sonia Selicean
Cong Wang
Sergi Guixé-Muntet
Horia Stefanescu
Norifumi Kawada
Jordi Gracia-Sancho
Publication date
01-02-2021
Publisher
Springer India
Published in
Hepatology International / Issue 1/2021
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-021-10135-4

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