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01-12-2020 | Hepatic Encephalopathy | Letter to the Editor

COVID-19 in decompensated cirrhosis

Authors: Mohamed Rela, Vaibhav Patil, Gomathy Narasimhan, Dinesh Jothimani

Published in: Hepatology International | Issue 6/2020

Excerpt

COVID-19 is associated with higher mortality in patients pre-existing comorbidities. There has been several reports recently describing abnormalities in liver function tests (LFT) in COVID-19 patients ranging from very mild abnormalities in the non-cirrhotic patients to moderate elevation of liver enzymes in the cirrhotic patients [1, 2]. Our recent review showed that 14–53% of patients with COVID-19 developed hepatic dysfunction and 2–11% of patients had underlying chronic liver disease [3]. …

Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708–1720. https://doi.org/10.1056/NEJMoa2002032CrossRefPubMed

Grasselli G, Zangrillo A, Zanella A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy [published online ahead of print, 2020 Apr 6]. JAMA 2020;323(16):1574–1581. https://doi.org/10.1001/jama.2020.5394CrossRefPubMedPubMedCentral

Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I, Rela M. COVID-19 and Liver [published online ahead of print, 2020 Jun 15]. J Hepatol 2020. https://doi.org/10.1016/j.jhep.2020.06.006

Wang Y, Liu S, Liu H, et al. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19 [published online ahead of print, 2020 May 10]. J Hepatol 2020. https://doi.org/10.1016/j.jhep.2020.05.002

Asadi-Pooya AA, Simani L. Central nervous system manifestations of COVID-19: a systematic review. J Neurol Sci 2020;413:116832. https://doi.org/10.1016/j.jns.2020.116832CrossRefPubMedPubMedCentral

Moon A, Webb G, et al. High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: preliminary results from an international registry. J Hepatol 2020. https://doi.org/10.1016/j.jhep.2020.05.013CrossRefPubMedPubMedCentral

Title: COVID-19 in decompensated cirrhosis
Authors: Mohamed Rela
Vaibhav Patil
Gomathy Narasimhan
Dinesh Jothimani
Publication date: 01-12-2020
Publisher: Springer India
Keywords: Hepatic Encephalopathy
SARS-CoV-2
Ascites
COVID-19
Hepatic Encephalopathy
CT of the Thorax
Published in: Hepatology International / Issue 6/2020
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI: https://doi.org/10.1007/s12072-020-10092-4

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