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01-06-2010 | Original Paper

Autocrine human growth hormone expression leads to resistance of MCF-7 cells to tamoxifen

Authors: Majid Mojarrad, Majid Momeny, Fatemeh Mansuri, Yassan Abdolazimi, Mina Hajifaraj Tabrizi, Seyed Hamidollah Ghaffari, Seyed Mohammad Tavangar, Mohammad Hussein Modarressi

Published in: Medical Oncology | Issue 2/2010

Abstract

Tamoxifen is the most common antiestrogen used in the treatment of estrogen-positive breast cancer but its adverse effects and also resistance to this drug are serious challenges in the treatment of breast cancer. Characterization of mechanisms responsible for these adverse effects can lead to design of more efficient therapeutic strategies for the treatment of breast cancer. Here, we used a cellular model to evaluate the effects of autocrine expression of human growth hormone on responses of cells to tamoxifen. Our results imply for the first time that autocrine expression of growth hormone in human breast adenocarcinoma cell line, MCF-7, results in increase in cell proliferative capacity of cells even in the presence of tamoxifen. This effect may be due to up-regulation of G-coupled estrogen receptor, GPR30, which is activated by tamoxifen.

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Title: Autocrine human growth hormone expression leads to resistance of MCF-7 cells to tamoxifen
Authors: Majid Mojarrad
Majid Momeny
Fatemeh Mansuri
Yassan Abdolazimi
Mina Hajifaraj Tabrizi
Seyed Hamidollah Ghaffari
Seyed Mohammad Tavangar
Mohammad Hussein Modarressi
Publication date: 01-06-2010
Publisher: Springer US
Published in: Medical Oncology / Issue 2/2010
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-009-9237-5

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