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01-09-2019 | Case Report

Intraductal Papillary Neoplasm of the Bile Duct (IPNB): Case Report and Literature Review of a Challenging Disease to Diagnose

Authors: Ignacio Fuente, Marcos Gonzalez, Martin de Santibañes, Juan Pekolj, Oscar Mazza, Eduardo de Santibañes, Rodrigo Sanchez Claria

Published in: Journal of Gastrointestinal Cancer | Issue 3/2019

Excerpt

Intraductal papillary neoplasm of the bile duct (IPNB) is defined as a bile duct epithelial tumor characterized by papillary proliferation within the bile duct lumen [1, 2]. It has been established as a precursor lesion towards cholangiocarcinoma and includes previous categories of premalignant biliary lesions. There are certain morphological features of these tumors, especially intraductal papillary growth pattern, that are similar to IPMN of the páncreas. Opposed to cystic mucinous tumors, the IPNB shows communication with the biliary tract and no ovarian like stroma (OLS) in the pathology findings [3]. …

Jung G, Park KM, Lee SS, Yu E, Hong SM, Kim J. Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct. J Hepatol. 2012;57:787–93.

Rocha FG, Lee H, Katabi N, RP DM, Fong Y, D’Angelica MI, et al. Intraductal papillary neoplasm of the bile duct: a biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? Hepatology. 2012;56(4):1352–60.

Kubota K, Nakanuma Y, Kondo F, Hachiya H, Miyazaki M, Nagino M, et al. Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association. J Hepatobiliary Pancreat Sci. 2014;21(3):176–85. https://doi.org/10.1002/jhbp.23.CrossRefPubMed

Zen Y, Fujii T, Itatsu K, Nakamura K, Minato H, Kasashima S, et al. Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology. 2006;44(5):1333–43. https://doi.org/10.1002/hep.21387.CrossRefPubMed

Barton JG, Barrett DA, Maricevich MA, Schnelldorfer T, Wood CM, Smyrk TC, et al. Intraductal papillary mucinous neoplasm of the biliary tract: a real disease? HPB. 2009;11(8):684–91. https://doi.org/10.1111/j.1477-2574.2009.00122.x.CrossRefPubMedPubMedCentral

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WHO classification of tumours of the Digestive System. 4th Edition. 2010.

Nakanuma Y, Zen Y, Harada K, Ikeda H, Sato Y, Uehara T, et al. Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach. J Hepatobiliary Pancreat Sci. 2010;17(3):211–22. https://doi.org/10.1007/s00534-009-0158-7.CrossRefPubMed

Wang X, Cai YQ, Chen YH, Liu XB. Biliary tract intraductal papillary mucinous neoplasm: report of 19 cases. World J Gastroenterol. 2015;21(14):4261–7. https://doi.org/10.3748/wjg.v21.i14.4261.CrossRefPubMedPubMedCentral

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Hong GS, Byun JH, Kim JH, et al. Thread sign in biliary intraductal papillary mucinous neoplasm: a novel specific finding for MRI. Eur Radiol. 2016;26(9):3112–20. https://doi.org/10.1007/s00330-015-4158-5.CrossRefPubMed

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Aljebreen AM, Romagnuolo J, Perini R, Sutherland F. Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesions. World Journal of Gastroenterology : WJG. 2007;13(29):3962–6. https://doi.org/10.3748/wjg.v13.i29.3962. CrossRefPubMed

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Talar-Wojnarowska R, Pazurek M, Durko L, et al. Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions. Oncol Lett. 2013;5(2):613–6. https://doi.org/10.3892/ol.2012.1071.CrossRefPubMed

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Yang J, Wang W, Yan L. The clinicopathological features of intraductal papillary neoplasms of the bile duct in a Chinese population. Digest Liver Dis. 2012;44(3):251–6. https://doi.org/10.1016/j.dld.2011.08.014.CrossRef

Title: Intraductal Papillary Neoplasm of the Bile Duct (IPNB): Case Report and Literature Review of a Challenging Disease to Diagnose
Authors: Ignacio Fuente
Marcos Gonzalez
Martin de Santibañes
Juan Pekolj
Oscar Mazza
Eduardo de Santibañes
Rodrigo Sanchez Claria
Publication date: 01-09-2019
Publisher: Springer US
Published in: Journal of Gastrointestinal Cancer / Issue 3/2019
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-018-0057-8

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