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Published in: Current Urology Reports 1/2019

01-01-2019 | Kidney Transplantation | Kidney Diseases (G Ciancio, Section Editor)

Use of Mannitol for Ischemia Reperfusion Injury in Kidney Transplant and Partial Nephrectomies—Review of Literature

Authors: Jose Alejandro Lugo-Baruqui, Rajinikanth Ayyathurai, Adavan Sriram, Kothai Divya Pragatheeshwar

Published in: Current Urology Reports | Issue 1/2019

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Abstract

Purpose of Review

Few procedures involve the ischemia-reperfusion injury to organs purposely. Two clear examples in urologic surgery consist on kidney transplantation and partial nephrectomies.

Recent Findings

Mannitol is an osmotic diuretic that is commonly used in partial nephrectomies and kidney transplantation to increase renal blood flow and decrease warm-ischemia-related renal injury to preserve estimated glomerular filtration rate (eGFR).

Summary

We review the current evidence for the use of mannitol and its effects on these procedures.
Literature
1.
go back to reference Volpe A, Cadeddu JA, Cestari A, Gill IS, Jewett MAS, Joniau S, et al. Contemporary management of small renal masses. Eur Urol. 2011;60:501–15.CrossRef Volpe A, Cadeddu JA, Cestari A, Gill IS, Jewett MAS, Joniau S, et al. Contemporary management of small renal masses. Eur Urol. 2011;60:501–15.CrossRef
2.
go back to reference Bjurlin MA, Walter D, Taksler GB, Huang WC, Wysock JS, Sivarajan G, et al. National trends in the utilization of partial nephrectomy before and after the establishment of AUA guidelines for the management of renal masses. Urology. 2013;82:1283–90.CrossRef Bjurlin MA, Walter D, Taksler GB, Huang WC, Wysock JS, Sivarajan G, et al. National trends in the utilization of partial nephrectomy before and after the establishment of AUA guidelines for the management of renal masses. Urology. 2013;82:1283–90.CrossRef
3.
go back to reference • Shawkat H, Westwood M, Mortimer A. Mannitol: a review of its clinical uses. Contin Educ Anaesth Crit Care Pain. 2012;12(2):82–5 Comprehensive pharmacological review of mannitol, itls clinical uses in anesthesiology, and side effects. CrossRef • Shawkat H, Westwood M, Mortimer A. Mannitol: a review of its clinical uses. Contin Educ Anaesth Crit Care Pain. 2012;12(2):82–5 Comprehensive pharmacological review of mannitol, itls clinical uses in anesthesiology, and side effects. CrossRef
4.
go back to reference Johnston PA, Bernard DB, Perrin NS, Levinsky NG. Prostaglandins mediate the vasodilatory effect of mannitol in the hypoperfused rat kidney. J Clin Invest. 1981;68:127–33.CrossRef Johnston PA, Bernard DB, Perrin NS, Levinsky NG. Prostaglandins mediate the vasodilatory effect of mannitol in the hypoperfused rat kidney. J Clin Invest. 1981;68:127–33.CrossRef
5.
go back to reference • Bugge JF, Hartmann A, Osnes S, Bentdal O, Stenstrøm J. Immediate and early renal function after living donor transplantation. Nephrol Dial Transplant. 1999;14(2):389–93 Classic paper that describes normalization of renal function of kidneys transplanted from living donors after volume expansion comb ined with the use of mannitol and furosemide. CrossRef • Bugge JF, Hartmann A, Osnes S, Bentdal O, Stenstrøm J. Immediate and early renal function after living donor transplantation. Nephrol Dial Transplant. 1999;14(2):389–93 Classic paper that describes normalization of renal function of kidneys transplanted from living donors after volume expansion comb ined with the use of mannitol and furosemide. CrossRef
6.
go back to reference P S, van der Woude FJ. Perioperative fluid management in renal transplantation: a narrative review of the literature. Transpl Int. 2006;19(12):947–59.CrossRef P S, van der Woude FJ. Perioperative fluid management in renal transplantation: a narrative review of the literature. Transpl Int. 2006;19(12):947–59.CrossRef
8.
go back to reference van Valenberg PL, Hoitsma AJ, Tiggeler RG, Berden JH, van Lier HJ, Koene RA. Mannitol as an indispensable constituent of an intraoperative hydration protocol for the prevention of acute renal failure after renal cadaveric transplantation. Transplantation. 1987;44(6):784–8.CrossRef van Valenberg PL, Hoitsma AJ, Tiggeler RG, Berden JH, van Lier HJ, Koene RA. Mannitol as an indispensable constituent of an intraoperative hydration protocol for the prevention of acute renal failure after renal cadaveric transplantation. Transplantation. 1987;44(6):784–8.CrossRef
10.
go back to reference Hanif F, Macrae AN, Littlejohn MG, Clancy MJ, Murio E. Outcome of renal transplantation with and without intra-operative diuretics. Int J Surg. 2011;9:460–3.CrossRef Hanif F, Macrae AN, Littlejohn MG, Clancy MJ, Murio E. Outcome of renal transplantation with and without intra-operative diuretics. Int J Surg. 2011;9:460–3.CrossRef
11.
go back to reference Tiggeler RG, Berden JH, Hoitsma AJ, Koene RA. Prevention of acute tubular necrosis in cadaveric kidney transplantation by the combined use of mannitol and moderate hydration. Ann Surg. 1985;201:246–51.CrossRef Tiggeler RG, Berden JH, Hoitsma AJ, Koene RA. Prevention of acute tubular necrosis in cadaveric kidney transplantation by the combined use of mannitol and moderate hydration. Ann Surg. 1985;201:246–51.CrossRef
12.
go back to reference Weimar W, Geerlings W, Bijnen AB, et al. A controlled study on the effect of mannitol on immediate renal function after cadaver donor kidney transplantation. Transplantation. 1983;35:99.PubMed Weimar W, Geerlings W, Bijnen AB, et al. A controlled study on the effect of mannitol on immediate renal function after cadaver donor kidney transplantation. Transplantation. 1983;35:99.PubMed
13.
go back to reference Namnesnikov M, Fedorov D, Abu-Gazala S, Weinbroum AA, Khoury W. Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion. J Surg Res. 2010;160(1):163–8.CrossRef Namnesnikov M, Fedorov D, Abu-Gazala S, Weinbroum AA, Khoury W. Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion. J Surg Res. 2010;160(1):163–8.CrossRef
14.
go back to reference •• Andrews PM, Cooper M, Verbesey J, Ghasemian S, Rogalsky D, Moody P, et al. Mannitol infusion within 15 min of cross-clamp improves living donor kidney preservation. Transplantation. 2014;98(8):893–7 Classic paper with clinical evidence for the use of mannitol in kidney transplant. CrossRef •• Andrews PM, Cooper M, Verbesey J, Ghasemian S, Rogalsky D, Moody P, et al. Mannitol infusion within 15 min of cross-clamp improves living donor kidney preservation. Transplantation. 2014;98(8):893–7 Classic paper with clinical evidence for the use of mannitol in kidney transplant. CrossRef
15.
go back to reference Esfahani HS, Nooraei N, Asgary M, Hashemian MR. The effect of mannitol administration to kidney donor on short-term outcomes of kidney transplantation. Saudi J Kidney Dis Transpl. 2014;25(6):1154–9.CrossRef Esfahani HS, Nooraei N, Asgary M, Hashemian MR. The effect of mannitol administration to kidney donor on short-term outcomes of kidney transplantation. Saudi J Kidney Dis Transpl. 2014;25(6):1154–9.CrossRef
16.
go back to reference Prerez-Perez AJ, Pazos B, Sobrado J, Gonzalez L, Gandara A. Acute renal failure following massive mannitol infusion. Am J Nephrol. 2002;22:573–5.CrossRef Prerez-Perez AJ, Pazos B, Sobrado J, Gonzalez L, Gandara A. Acute renal failure following massive mannitol infusion. Am J Nephrol. 2002;22:573–5.CrossRef
17.
go back to reference Power NE, Maschino AC, Savage C, Silberstein JL, Thorner D, Tarin T, et al. Intraoperative mannitol use does not improve long-term renal function outcomes after minimally invasive partial nephrectomy. Urology. 2012;79:821–6.CrossRef Power NE, Maschino AC, Savage C, Silberstein JL, Thorner D, Tarin T, et al. Intraoperative mannitol use does not improve long-term renal function outcomes after minimally invasive partial nephrectomy. Urology. 2012;79:821–6.CrossRef
18.
go back to reference Omae K, Kondo T, Takagi T, Iizuka J, Kobayashi H, Hashimoto Y, et al. Mannitol has no impact on renal function after open partial nephrectomy in solitary kidneys. Int J Urol. 2014;21:200–3.CrossRef Omae K, Kondo T, Takagi T, Iizuka J, Kobayashi H, Hashimoto Y, et al. Mannitol has no impact on renal function after open partial nephrectomy in solitary kidneys. Int J Urol. 2014;21:200–3.CrossRef
19.
go back to reference Spaliviero M, Power NE, Murray KS, Sjoberg DD, Benfante NE, Bernstein ML, et al. Intravenous mannitol versus placebo during partial nephrectomy in patients with Normal kidney function: a double-blind, clinically-integrated, randomized trial [Figure presented]. Eur Urol. 2018;73:53–9.CrossRef Spaliviero M, Power NE, Murray KS, Sjoberg DD, Benfante NE, Bernstein ML, et al. Intravenous mannitol versus placebo during partial nephrectomy in patients with Normal kidney function: a double-blind, clinically-integrated, randomized trial [Figure presented]. Eur Urol. 2018;73:53–9.CrossRef
21.
go back to reference Novick AC. Renal hypothermia: in vivo and ex vivo. Urol Clin North Am. 1983;10(4):637-44 Novick AC. Renal hypothermia: in vivo and ex vivo. Urol Clin North Am. 1983;10(4):637-44
22.
go back to reference Gelman S. Does mannitol save the kidney? Anesth Analg. 1996;82(5):899-901 Gelman S. Does mannitol save the kidney? Anesth Analg. 1996;82(5):899-901
Metadata
Title
Use of Mannitol for Ischemia Reperfusion Injury in Kidney Transplant and Partial Nephrectomies—Review of Literature
Authors
Jose Alejandro Lugo-Baruqui
Rajinikanth Ayyathurai
Adavan Sriram
Kothai Divya Pragatheeshwar
Publication date
01-01-2019

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