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Current Urology Reports
Published in: Current Urology Reports 1/2019

01-01-2019 | Kidney Cancer | Kidney Diseases (G Ciancio, Section Editor)

A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma

Authors: Caroline E. Nunes-Xavier, Javier C. Angulo, Rafael Pulido, José I. López

Published in: Current Urology Reports | Issue 1/2019

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Abstract

Purpose of Review

Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient’s life.

Recent Findings

Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunohistochemical detection of PD-1/PD-L1 positivity in inflammatory cells in the tumor, which makes the role of the pathologist crucial, but clinical concern upon the reliability to use immunohistochemistry (IHC) to predict therapeutic response is increasing.

Summary

We review the state of the art of the immune checkpoint inhibition in CCRCC, from the basic science and its fundamentals to the daily application in clinical routine.
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Metadata
Title
A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma
Authors
Caroline E. Nunes-Xavier
Javier C. Angulo
Rafael Pulido
José I. López
Publication date
01-01-2019
Publisher
Springer US
Published in
Current Urology Reports / Issue 1/2019
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-019-0866-8

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