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Open Access 01-06-2013 | Imaging (T Lang, Section Editor)

High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group

Authors: Angela M. Cheung, Jonathan D. Adachi, David A. Hanley, David L. Kendler, K. Shawn Davison, Robert Josse, Jacques P. Brown, Louis-Georges Ste-Marie, Richard Kremer, Marta C. Erlandson, Larry Dian, Andrew J. Burghardt, Steven K. Boyd

Published in: Current Osteoporosis Reports | Issue 2/2013

Abstract

Bone structure is an integral determinant of bone strength. The availability of high resolution peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure three-dimensional bone microarchitecture and volumetric bone mineral density in vivo, with accuracy previously unachievable and with relatively low-dose radiation. Recent studies using this novel imaging tool have increased our understanding of age-related changes and sex differences in bone microarchitecture, as well as the effect of different pharmacological therapies. One advantage of this novel tool is the use of finite element analysis modelling to non-invasively estimate bone strength and predict fractures using reconstructed three-dimensional images. In this paper, we describe the strengths and limitations of HR-pQCT and review the clinical studies using this tool.

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Title: High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group
Authors: Angela M. Cheung
Jonathan D. Adachi
David A. Hanley
David L. Kendler
K. Shawn Davison
Robert Josse
Jacques P. Brown
Louis-Georges Ste-Marie
Richard Kremer
Marta C. Erlandson
Larry Dian
Andrew J. Burghardt
Steven K. Boyd
Publication date: 01-06-2013
Publisher: Current Science Inc.
Published in: Current Osteoporosis Reports / Issue 2/2013
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-013-0140-9

At a glance: The STEP trials

Springer Medicine

High-Resolution Peripheral Quantitative Computed Tomography for the Assessment of Bone Strength and Structure: A Review by the Canadian Bone Strength Working Group

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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