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01-06-2013 | Skeletal Regulations (D Gaddy, Section Editor)

Notch Signaling and Bone Remodeling

Authors: Jenna Regan, Fanxin Long

Published in: Current Osteoporosis Reports | Issue 2/2013

Abstract

Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling for proper differentiation and function, and the specific roles of Notch are dependent on the differentiation status of the cell. The recent discovery of activating NOTCH2 mutations as the cause of Hajdu-Cheney syndrome has highlighted the significance of Notch signaling in human bone physiology.

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Title: Notch Signaling and Bone Remodeling
Authors: Jenna Regan
Fanxin Long
Publication date: 01-06-2013
Publisher: Current Science Inc.
Published in: Current Osteoporosis Reports / Issue 2/2013
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-013-0145-4

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Notch Signaling and Bone Remodeling

Abstract

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