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Published in:

01-06-2011

A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

Authors: Erinn B. Rankin, Amato J. Giaccia, Ernestina Schipani

Published in: Current Osteoporosis Reports | Issue 2/2011

Abstract

Hypoxic signaling plays an essential role in maintaining oxygen homeostasis and cell survival. Hypoxia-inducible transcription factors HIF-1 and HIF-2 are central mediators of the cellular response to hypoxia by regulating the expression of genes controlling metabolic adaptation, oxygen delivery, and survival in response to oxygen deprivation. Recent studies have identified an important role for HIF-1 and HIF-2 in the regulation of skeletal development, bone formation, and regeneration, as well as joint formation and homeostasis. In addition, overexpression of HIF-1 and HIF-2 is clinically associated with osteosarcoma and osteoarthritis. Together, these findings implicate hypoxic signaling as a central regulator of bone biology and disease.

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Title: A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis
Authors: Erinn B. Rankin
Amato J. Giaccia
Ernestina Schipani
Publication date: 01-06-2011
Publisher: Current Science Inc.
Published in: Current Osteoporosis Reports / Issue 2/2011
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-011-0047-2

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A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

Abstract

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