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Published in: Current Hypertension Reports 5/2013

01-10-2013 | Pediatric Hypertension (JT Flynn, Section Editor)

Primary Hypertension in Childhood

Authors: Barbara S. Bucher, Alessandra Ferrarini, Nico Weber, Marina Bullo, Mario G. Bianchetti, Giacomo D. Simonetti

Published in: Current Hypertension Reports | Issue 5/2013

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Abstract

There is growing concern about elevated blood pressure in children and adolescents, because of its association with the obesity epidemic. Moreover, cardiovascular function and blood pressure level are determined in childhood and track into adulthood. Primary hypertension in childhood is defined by persistent blood pressure values ≥ the 95th percentile and without a secondary cause. Preventable risk factors for elevated blood pressure in childhood are overweight, dietary habits, salt intake, sedentary lifestyle, poor sleep quality and passive smoking, whereas non-preventable risk factors include race, gender, genetic background, low birth weight, prematurity, and socioeconomic inequalities. Several different pathways are implicated in the development of primary hypertension, including obesity, insulin resistance, activation of the sympathetic nervous system, alterations in sodium homeostasis, renin-angiotensin system and altered vascular function. Prevention of adult cardiovascular disease should begin in childhood by regularly screening for high blood pressure, counseling for healthy lifestyle and avoiding preventable risk factors.
Literature
1.
go back to reference Rosendorff C, Black HR, Cannon CP, et al. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention. Circulation. 2007;115:2761–88.PubMedCrossRef Rosendorff C, Black HR, Cannon CP, et al. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention. Circulation. 2007;115:2761–88.PubMedCrossRef
2.
go back to reference McNiece KL, Poffenbarger TS, Turner JL, et al. Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr. 2007;150:640–4. 644 e641.PubMedCrossRef McNiece KL, Poffenbarger TS, Turner JL, et al. Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr. 2007;150:640–4. 644 e641.PubMedCrossRef
3.
go back to reference Bao W, Threefoot SA, Srinivasan SR, Berenson GS. Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am J Hypertens. 1995;8:657–65.PubMedCrossRef Bao W, Threefoot SA, Srinivasan SR, Berenson GS. Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am J Hypertens. 1995;8:657–65.PubMedCrossRef
4.
go back to reference Beckett LA, Rosner B, Roche AF, Guo S. Serial changes in blood pressure from adolescence into adulthood. Am J Epidemiol. 1992;135:1166–77.PubMed Beckett LA, Rosner B, Roche AF, Guo S. Serial changes in blood pressure from adolescence into adulthood. Am J Epidemiol. 1992;135:1166–77.PubMed
5.
go back to reference Hofman A. Blood pressure in childhood: an epidemiological approach to the aetiology of hypertension. J Hypertens. 1984;2:323–8.PubMed Hofman A. Blood pressure in childhood: an epidemiological approach to the aetiology of hypertension. J Hypertens. 1984;2:323–8.PubMed
6.
go back to reference Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation. 2008;117:3171–80.PubMedCrossRef Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation. 2008;117:3171–80.PubMedCrossRef
7.
go back to reference National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114:555–76.CrossRef National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114:555–76.CrossRef
8.
go back to reference Simonetti GD, Rizzi M, Bianchetti MG. Simple references for managing arterial hypertension in children with kidney disease. J Hypertens. 2010;28:1109. author reply 1109–1110.PubMedCrossRef Simonetti GD, Rizzi M, Bianchetti MG. Simple references for managing arterial hypertension in children with kidney disease. J Hypertens. 2010;28:1109. author reply 1109–1110.PubMedCrossRef
9.
go back to reference Somu S, Sundaram B, Kamalanathan AN. Early detection of hypertension in general practice. Arch Dis Child. 2003;88:302.PubMedCrossRef Somu S, Sundaram B, Kamalanathan AN. Early detection of hypertension in general practice. Arch Dis Child. 2003;88:302.PubMedCrossRef
10.
go back to reference Lurbe E, Cifkova R, Cruickshank JK, et al. Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension. J Hypertens. 2009;27:1719–42.PubMedCrossRef Lurbe E, Cifkova R, Cruickshank JK, et al. Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension. J Hypertens. 2009;27:1719–42.PubMedCrossRef
11.
go back to reference Kapur G, Mattoo TK. Primary hypertension. In: Flynn JT, Ingelfinger JR, Portman RJ, editors. Pediatric hypertension. 2nd ed. New York: Springer–Humana Press; 2011. p. 343–56.CrossRef Kapur G, Mattoo TK. Primary hypertension. In: Flynn JT, Ingelfinger JR, Portman RJ, editors. Pediatric hypertension. 2nd ed. New York: Springer–Humana Press; 2011. p. 343–56.CrossRef
12.
go back to reference Chiolero A, Cachat F, Burnier M, et al. Prevalence of hypertension in schoolchildren based on repeated measurements and association with overweight. J Hypertens. 2007;25:2209–17.PubMedCrossRef Chiolero A, Cachat F, Burnier M, et al. Prevalence of hypertension in schoolchildren based on repeated measurements and association with overweight. J Hypertens. 2007;25:2209–17.PubMedCrossRef
13.
go back to reference Falkner B, Lurbe E, Schaefer F. High blood pressure in children: clinical and health policy implications. J Clin Hypertens (Greenwich). 2010;12:261–76.CrossRef Falkner B, Lurbe E, Schaefer F. High blood pressure in children: clinical and health policy implications. J Clin Hypertens (Greenwich). 2010;12:261–76.CrossRef
14.
go back to reference Hansen ML, Gunn PW, Kaelber DC. Underdiagnosis of hypertension in children and adolescents. JAMA. 2007;298:874–9.PubMedCrossRef Hansen ML, Gunn PW, Kaelber DC. Underdiagnosis of hypertension in children and adolescents. JAMA. 2007;298:874–9.PubMedCrossRef
15.
go back to reference Brady TM, Solomon BS, Neu AM, et al. Patient-, provider-, and clinic-level predictors of unrecognized elevated blood pressure in children. Pediatrics. 2010;125:e1286–93.PubMedCrossRef Brady TM, Solomon BS, Neu AM, et al. Patient-, provider-, and clinic-level predictors of unrecognized elevated blood pressure in children. Pediatrics. 2010;125:e1286–93.PubMedCrossRef
16.
go back to reference Muntner P, He J, Cutler JA, et al. Trends in blood pressure among children and adolescents. JAMA. 2004;291:2107–13.PubMedCrossRef Muntner P, He J, Cutler JA, et al. Trends in blood pressure among children and adolescents. JAMA. 2004;291:2107–13.PubMedCrossRef
17.
go back to reference • Simonetti GD, Schwertz R, Klett M, et al. Determinants of blood pressure in preschool children: the role of parental smoking. Circulation. 2011;123:292–8. This report indicates that in healthy preschool children, parental smoking is an independent risk factor for higher blood pressure, adding to other familial and environmental risk factors.PubMedCrossRef • Simonetti GD, Schwertz R, Klett M, et al. Determinants of blood pressure in preschool children: the role of parental smoking. Circulation. 2011;123:292–8. This report indicates that in healthy preschool children, parental smoking is an independent risk factor for higher blood pressure, adding to other familial and environmental risk factors.PubMedCrossRef
18.
go back to reference • Chiolero A, Paradis G, Madeleine G, et al. Discordant secular trends in elevated blood pressure and obesity in children and adolescents in a rapidly developing country. Circulation. 2009;119:558–65. In developed countries, secular trend studies demonstrate that the increase in the prevalence of arterial hypertension in childhood is mainly due to the increase in the prevalence of obesity. Interestingly, this report shows that in developing countries, such as the Seychelles, the secular trend for these associations seems not to be present: while BMI increases over the years, BP seems to decrease. A tentative explanation for this discrepancy between industrialized and developing countries is the fact that the prevalence of overweight/obesity may need to reach a very high level before an effect on BP can be measured at a population level.PubMedCrossRef • Chiolero A, Paradis G, Madeleine G, et al. Discordant secular trends in elevated blood pressure and obesity in children and adolescents in a rapidly developing country. Circulation. 2009;119:558–65. In developed countries, secular trend studies demonstrate that the increase in the prevalence of arterial hypertension in childhood is mainly due to the increase in the prevalence of obesity. Interestingly, this report shows that in developing countries, such as the Seychelles, the secular trend for these associations seems not to be present: while BMI increases over the years, BP seems to decrease. A tentative explanation for this discrepancy between industrialized and developing countries is the fact that the prevalence of overweight/obesity may need to reach a very high level before an effect on BP can be measured at a population level.PubMedCrossRef
19.
go back to reference Flynn J, Zhang Y, Solar-Yohay S, Shi V. Clinical and demographic characteristics of children with hypertension. Hypertension. 2012;60:1047–54.PubMedCrossRef Flynn J, Zhang Y, Solar-Yohay S, Shi V. Clinical and demographic characteristics of children with hypertension. Hypertension. 2012;60:1047–54.PubMedCrossRef
20.
go back to reference Rosner B, Prineas R, Daniels SR, Loggie J. Blood pressure differences between blacks and whites in relation to body size among US children and adolescents. Am J Epidemiol. 2000;151:1007–19.PubMedCrossRef Rosner B, Prineas R, Daniels SR, Loggie J. Blood pressure differences between blacks and whites in relation to body size among US children and adolescents. Am J Epidemiol. 2000;151:1007–19.PubMedCrossRef
21.
go back to reference Archbold KH, Vasquez MM, Goodwin JL, Quan SF. Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: report from the Tucson Children's Assessment of Sleep Apnea Study. J Pediatr. 2012;161:26–30.PubMedCrossRef Archbold KH, Vasquez MM, Goodwin JL, Quan SF. Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: report from the Tucson Children's Assessment of Sleep Apnea Study. J Pediatr. 2012;161:26–30.PubMedCrossRef
22.
go back to reference Javaheri S, Storfer-Isser A, Rosen CL, Redline S. Sleep quality and elevated blood pressure in adolescents. Circulation. 2008;118:1034–40.PubMedCrossRef Javaheri S, Storfer-Isser A, Rosen CL, Redline S. Sleep quality and elevated blood pressure in adolescents. Circulation. 2008;118:1034–40.PubMedCrossRef
23.
go back to reference Bixler EO, Vgontzas AN, Lin HM, et al. Blood pressure associated with sleep-disordered breathing in a population sample of children. Hypertension. 2008;52:841–6.PubMedCrossRef Bixler EO, Vgontzas AN, Lin HM, et al. Blood pressure associated with sleep-disordered breathing in a population sample of children. Hypertension. 2008;52:841–6.PubMedCrossRef
24.
go back to reference Stein DJ, Scott K, Haro Abad JM, et al. Early childhood adversity and later hypertension: data from the World Mental Health Survey. Ann Clin Psychiatry. 2010;22:19–28.PubMed Stein DJ, Scott K, Haro Abad JM, et al. Early childhood adversity and later hypertension: data from the World Mental Health Survey. Ann Clin Psychiatry. 2010;22:19–28.PubMed
25.
go back to reference Pludowski P, Litwin M, Niemirska A, et al. Accelarated skeletal maturation in children with primary hypertension. Hypertension. 2009;54:1234–9.PubMedCrossRef Pludowski P, Litwin M, Niemirska A, et al. Accelarated skeletal maturation in children with primary hypertension. Hypertension. 2009;54:1234–9.PubMedCrossRef
26.
go back to reference Brady TM, Fivush B, Parekh RS, Flynn JT. Racial differences among children with primary hypertension. Pediatrics. 2010;126:931–7.PubMedCrossRef Brady TM, Fivush B, Parekh RS, Flynn JT. Racial differences among children with primary hypertension. Pediatrics. 2010;126:931–7.PubMedCrossRef
27.
go back to reference Berenson GS, Chen W, Dasmahapatra P, et al. Stimulus response of blood pressure in black and white young individuals helps explain racial divergence in adult cardiovascular disease: the Bogalusa Heart Study. J Am Soc Hypertens. 2011;5:230–8.PubMedCrossRef Berenson GS, Chen W, Dasmahapatra P, et al. Stimulus response of blood pressure in black and white young individuals helps explain racial divergence in adult cardiovascular disease: the Bogalusa Heart Study. J Am Soc Hypertens. 2011;5:230–8.PubMedCrossRef
28.
go back to reference Rodriguez-Moran M, Aradillas-Garcia C, Simental-Mendia LE, et al. Family history of hypertension and cardiovascular risk factors in prepubertal children. Am J Hypertens. 2010;23:299–304.PubMedCrossRef Rodriguez-Moran M, Aradillas-Garcia C, Simental-Mendia LE, et al. Family history of hypertension and cardiovascular risk factors in prepubertal children. Am J Hypertens. 2010;23:299–304.PubMedCrossRef
29.
go back to reference • Oikonen M, Tikkanen E, Juhola J, et al. Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study. Hypertension. 2011;58:1079–85. The findings of this study show that genetic variants are associated with preclinical blood pressure traits in childhood; individuals with several susceptibility alleles have, on average, a 0.5-mmHg higher blood pressure, and this tracking continues from childhood to adulthood.PubMedCrossRef • Oikonen M, Tikkanen E, Juhola J, et al. Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study. Hypertension. 2011;58:1079–85. The findings of this study show that genetic variants are associated with preclinical blood pressure traits in childhood; individuals with several susceptibility alleles have, on average, a 0.5-mmHg higher blood pressure, and this tracking continues from childhood to adulthood.PubMedCrossRef
30.
go back to reference Ajala AR, Almeida SS, Rangel M, et al. Association of ACE gene insertion/deletion polymorphism with birth weight, blood pressure levels, and ACE activity in healthy children. Am J Hypertens. 2012;25:827–32.PubMedCrossRef Ajala AR, Almeida SS, Rangel M, et al. Association of ACE gene insertion/deletion polymorphism with birth weight, blood pressure levels, and ACE activity in healthy children. Am J Hypertens. 2012;25:827–32.PubMedCrossRef
31.
go back to reference Bonamy AK, Kallen K, Norman M. High blood pressure in 2.5-year-old children born extremely preterm. Pediatrics. 2012;129:e1199–204.PubMedCrossRef Bonamy AK, Kallen K, Norman M. High blood pressure in 2.5-year-old children born extremely preterm. Pediatrics. 2012;129:e1199–204.PubMedCrossRef
32.
go back to reference Wolfenstetter A, Simonetti GD, Poschl J, et al. Altered cardiovascular rhythmicity in children born small for gestational age. Hypertension. 2012;60:865–70.PubMedCrossRef Wolfenstetter A, Simonetti GD, Poschl J, et al. Altered cardiovascular rhythmicity in children born small for gestational age. Hypertension. 2012;60:865–70.PubMedCrossRef
33.
go back to reference Nilsson PM, Lurbe E, Laurent S. The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome. J Hypertens. 2008;26:1049–57.PubMedCrossRef Nilsson PM, Lurbe E, Laurent S. The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome. J Hypertens. 2008;26:1049–57.PubMedCrossRef
34.
go back to reference de Boer MP, Ijzerman RG, de Jongh RT, et al. Birth weight relates to salt sensitivity of blood pressure in healthy adults. Hypertension. 2008;51:928–32.PubMedCrossRef de Boer MP, Ijzerman RG, de Jongh RT, et al. Birth weight relates to salt sensitivity of blood pressure in healthy adults. Hypertension. 2008;51:928–32.PubMedCrossRef
35.
go back to reference Rostand SG. Oligonephronia, primary hypertension and renal disease: 'is the child father to the man?'. Nephrol Dial Transplant. 2003;18:1434–8.PubMedCrossRef Rostand SG. Oligonephronia, primary hypertension and renal disease: 'is the child father to the man?'. Nephrol Dial Transplant. 2003;18:1434–8.PubMedCrossRef
36.
go back to reference Simonetti GD, Raio L, Surbek D, et al. Salt sensitivity of children with low birth weight. Hypertension. 2008;52:625–30.PubMedCrossRef Simonetti GD, Raio L, Surbek D, et al. Salt sensitivity of children with low birth weight. Hypertension. 2008;52:625–30.PubMedCrossRef
37.
go back to reference van den Berg G, van Eijsden M, Galindo-Garre F, et al. Explaining socioeconomic inequalities in childhood blood pressure and prehypertension: the ABCD study. Hypertension. 2013;61:35–41.PubMedCrossRef van den Berg G, van Eijsden M, Galindo-Garre F, et al. Explaining socioeconomic inequalities in childhood blood pressure and prehypertension: the ABCD study. Hypertension. 2013;61:35–41.PubMedCrossRef
38.
go back to reference • Loeffler LF, Navas-Acien A, Brady TM, et al. Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999–2006. Hypertension. 2012;59:811–7. The results of this study show that increasing levels of serum uric acid are associated with elevated blood pressure in healthy adolescents. Compared with <5.5 mg/dL, participants with a uric acid level ≥ 5.5 mg/dl had a two times higher odds of having elevated blood pressure.PubMedCrossRef • Loeffler LF, Navas-Acien A, Brady TM, et al. Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999–2006. Hypertension. 2012;59:811–7. The results of this study show that increasing levels of serum uric acid are associated with elevated blood pressure in healthy adolescents. Compared with <5.5 mg/dL, participants with a uric acid level ≥ 5.5 mg/dl had a two times higher odds of having elevated blood pressure.PubMedCrossRef
39.
go back to reference Shatat IF, Abdallah RT, Sas DJ, Hailpern SM. Serum uric acid in U.S. adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors. Pediatr Res. 2012. doi:10.1038/pr.2012.47.PubMed Shatat IF, Abdallah RT, Sas DJ, Hailpern SM. Serum uric acid in U.S. adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors. Pediatr Res. 2012. doi:10.​1038/​pr.​2012.​47.PubMed
40.
go back to reference Prebis JW, Gruskin AB, Polinsky MS, Baluarte HJ. Uric acid in childhood essential hypertension. J Pediatr. 1981;98:702–7.PubMedCrossRef Prebis JW, Gruskin AB, Polinsky MS, Baluarte HJ. Uric acid in childhood essential hypertension. J Pediatr. 1981;98:702–7.PubMedCrossRef
41.
go back to reference Feig DI. The role of uric acid in the pathogenesis of hypertension in the young. J Clin Hypertens (Greenwich). 2012;14:346–52.CrossRef Feig DI. The role of uric acid in the pathogenesis of hypertension in the young. J Clin Hypertens (Greenwich). 2012;14:346–52.CrossRef
42.
go back to reference Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008;300:924–32.PubMedCrossRef Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008;300:924–32.PubMedCrossRef
43.
go back to reference Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr. 2009;154:807–13.PubMedCrossRef Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr. 2009;154:807–13.PubMedCrossRef
44.
go back to reference Karpinski L, Plaksej R, Derzhko R, et al. Serum levels of interleukin-6, interleukin-10 and C-reactive protein in patients with myocardial infarction treated with primary angioplasty during a 6-month follow-up. Pol Arch Med Wewn. 2009;119:115–21.PubMed Karpinski L, Plaksej R, Derzhko R, et al. Serum levels of interleukin-6, interleukin-10 and C-reactive protein in patients with myocardial infarction treated with primary angioplasty during a 6-month follow-up. Pol Arch Med Wewn. 2009;119:115–21.PubMed
45.
go back to reference Boring L, Gosling J, Cleary M, Charo IF. Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 1998;394:894–7.PubMedCrossRef Boring L, Gosling J, Cleary M, Charo IF. Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 1998;394:894–7.PubMedCrossRef
46.
go back to reference •• Beveridge LA, Witham MD. Vitamin D and the cardiovascular system. Osteoporos Int. 2013. doi:10.1007/s00198-013-2281-1. An interesting review about the effect of Vitamin D on the cardiovascular system.PubMed •• Beveridge LA, Witham MD. Vitamin D and the cardiovascular system. Osteoporos Int. 2013. doi:10.​1007/​s00198-013-2281-1. An interesting review about the effect of Vitamin D on the cardiovascular system.PubMed
47.
go back to reference Hall JE, Mizelle HL, Hildebrandt DA, Brands MW. Abnormal pressure natriuresis. A cause or a consequence of hypertension? Hypertension. 1990;15:547–59.PubMedCrossRef Hall JE, Mizelle HL, Hildebrandt DA, Brands MW. Abnormal pressure natriuresis. A cause or a consequence of hypertension? Hypertension. 1990;15:547–59.PubMedCrossRef
48.
go back to reference Guyton A. Circulatory Physiology III: Arterial Pressure and Hypertension. Philadelphia: W.B. Saunders Company; 1980. Guyton A. Circulatory Physiology III: Arterial Pressure and Hypertension. Philadelphia: W.B. Saunders Company; 1980.
49.
go back to reference Amann K, Plank C, Dotsch J. Low nephron number–a new cardiovascular risk factor in children? Pediatr Nephrol. 2004;19:1319–23.PubMedCrossRef Amann K, Plank C, Dotsch J. Low nephron number–a new cardiovascular risk factor in children? Pediatr Nephrol. 2004;19:1319–23.PubMedCrossRef
50.
go back to reference Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens. 1988;1:335–47.PubMedCrossRef Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens. 1988;1:335–47.PubMedCrossRef
51.
go back to reference Keller G, Zimmer G, Mall G, et al. Nephron number in patients with primary hypertension. N Engl J Med. 2003;348:101–8.PubMedCrossRef Keller G, Zimmer G, Mall G, et al. Nephron number in patients with primary hypertension. N Engl J Med. 2003;348:101–8.PubMedCrossRef
52.
go back to reference Simonetti GD, Mohaupt MG, Bianchetti MG. Monogenic forms of hypertension. Eur J Pediatr. 2012;171:1433–9.PubMedCrossRef Simonetti GD, Mohaupt MG, Bianchetti MG. Monogenic forms of hypertension. Eur J Pediatr. 2012;171:1433–9.PubMedCrossRef
53.
go back to reference Tu W, Eckert GJ, DiMeglio LA, et al. Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension. 2011;58:818–24.PubMedCrossRef Tu W, Eckert GJ, DiMeglio LA, et al. Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension. 2011;58:818–24.PubMedCrossRef
54.
go back to reference • Babinska K, Kovacs L, Janko V, et al. Association between obesity and the severity of ambulatory hypertension in children and adolescents. J Am Soc Hypertens. 2012;6:356–63. This study investigates the relationship between hypertension and degree of obesity in children aged 7 to 18 years. The severity of high blood pressure increased significantly with the degree of obesity. Daytime systolic, diastolic, and mean arterial BPs increased significantly with increased BMI, whereas the nighttime pressure remained elevated regardless of the degree of obesity.PubMedCrossRef • Babinska K, Kovacs L, Janko V, et al. Association between obesity and the severity of ambulatory hypertension in children and adolescents. J Am Soc Hypertens. 2012;6:356–63. This study investigates the relationship between hypertension and degree of obesity in children aged 7 to 18 years. The severity of high blood pressure increased significantly with the degree of obesity. Daytime systolic, diastolic, and mean arterial BPs increased significantly with increased BMI, whereas the nighttime pressure remained elevated regardless of the degree of obesity.PubMedCrossRef
55.
go back to reference Puri M, Flynn JT, Garcia M, et al. The frequency of elevated blood pressure in obese minority youth. J Clin Hypertens (Greenwich). 2008;10:119–24.CrossRef Puri M, Flynn JT, Garcia M, et al. The frequency of elevated blood pressure in obese minority youth. J Clin Hypertens (Greenwich). 2008;10:119–24.CrossRef
56.
go back to reference Luepker RV, Jacobs DR, Prineas RJ, Sinaiko AR. Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996. J Pediatr. 1999;134:668–74.PubMedCrossRef Luepker RV, Jacobs DR, Prineas RJ, Sinaiko AR. Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996. J Pediatr. 1999;134:668–74.PubMedCrossRef
57.
go back to reference Flynn J. The changing face of pediatric hypertension in the era of the childhood obesity epidemic. Pediatr Nephrol. 2013;28:1059–66.PubMedCrossRef Flynn J. The changing face of pediatric hypertension in the era of the childhood obesity epidemic. Pediatr Nephrol. 2013;28:1059–66.PubMedCrossRef
58.
go back to reference Rademacher ER, Jacobs Jr DR, Moran A, et al. Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults. J Hypertens. 2009;27:1766–74.PubMedCrossRef Rademacher ER, Jacobs Jr DR, Moran A, et al. Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults. J Hypertens. 2009;27:1766–74.PubMedCrossRef
59.
go back to reference Kotchen TA. Obesity-related hypertension: epidemiology, pathophysiology, and clinical management. Am J Hypertens. 2010;23:1170–8.PubMedCrossRef Kotchen TA. Obesity-related hypertension: epidemiology, pathophysiology, and clinical management. Am J Hypertens. 2010;23:1170–8.PubMedCrossRef
60.
go back to reference •• Kotsis V, Stabouli S, Papakatsika S, et al. Mechanisms of obesity-induced hypertension. Hypertens Res. 2010;33:386–93. An important review about the pathophysiological mechanisms leading to arterial hypertension in obesity.PubMedCrossRef •• Kotsis V, Stabouli S, Papakatsika S, et al. Mechanisms of obesity-induced hypertension. Hypertens Res. 2010;33:386–93. An important review about the pathophysiological mechanisms leading to arterial hypertension in obesity.PubMedCrossRef
61.
go back to reference Shatat IF, Freeman KD, Vuguin PM, et al. Relationship between adiponectin and ambulatory blood pressure in obese adolescents. Pediatr Res. 2009;65:691–5.PubMedCrossRef Shatat IF, Freeman KD, Vuguin PM, et al. Relationship between adiponectin and ambulatory blood pressure in obese adolescents. Pediatr Res. 2009;65:691–5.PubMedCrossRef
62.
go back to reference Pacifico L, Anania C, Osborn JF, et al. Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents. Eur J Endocrinol. 2011;165:603–11.PubMedCrossRef Pacifico L, Anania C, Osborn JF, et al. Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents. Eur J Endocrinol. 2011;165:603–11.PubMedCrossRef
63.
go back to reference Croix B, Feig DI. Childhood hypertension is not a silent disease. Pediatr Nephrol. 2006;21:527–32.PubMedCrossRef Croix B, Feig DI. Childhood hypertension is not a silent disease. Pediatr Nephrol. 2006;21:527–32.PubMedCrossRef
64.
go back to reference Thompson M, Dana T, Bougatsos C, et al. Screening for hypertension in children and adolescents to prevent cardiovascular disease. Pediatrics. 2013;131:490–525.PubMedCrossRef Thompson M, Dana T, Bougatsos C, et al. Screening for hypertension in children and adolescents to prevent cardiovascular disease. Pediatrics. 2013;131:490–525.PubMedCrossRef
65.
go back to reference Daniels SR, Loggie JM, Khoury P, Kimball TR. Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation. 1998;97:1907–11.PubMedCrossRef Daniels SR, Loggie JM, Khoury P, Kimball TR. Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation. 1998;97:1907–11.PubMedCrossRef
66.
go back to reference Matteucci MC, Wuhl E, Picca S, et al. Left ventricular geometry in children with mild to moderate chronic renal insufficiency. J Am Soc Nephrol. 2006;17:218–26.PubMedCrossRef Matteucci MC, Wuhl E, Picca S, et al. Left ventricular geometry in children with mild to moderate chronic renal insufficiency. J Am Soc Nephrol. 2006;17:218–26.PubMedCrossRef
67.
go back to reference Urbina EM, Gidding SS, Bao W, et al. Effect of body size, ponderosity, and blood pressure on left ventricular growth in children and young adults in the Bogalusa Heart Study. Circulation. 1995;91:2400–6.PubMedCrossRef Urbina EM, Gidding SS, Bao W, et al. Effect of body size, ponderosity, and blood pressure on left ventricular growth in children and young adults in the Bogalusa Heart Study. Circulation. 1995;91:2400–6.PubMedCrossRef
68.
go back to reference Lande MB, Meagher CC, Fisher SG, et al. Left ventricular mass index in children with white coat hypertension. J Pediatr. 2008;153:50–4.PubMedCrossRef Lande MB, Meagher CC, Fisher SG, et al. Left ventricular mass index in children with white coat hypertension. J Pediatr. 2008;153:50–4.PubMedCrossRef
69.
go back to reference Redwine KM, Daniels SR. Prehypertension in adolescents: risk and progression. J Clin Hypertens (Greenwich). 2012;14:360–4.CrossRef Redwine KM, Daniels SR. Prehypertension in adolescents: risk and progression. J Clin Hypertens (Greenwich). 2012;14:360–4.CrossRef
70.
go back to reference Mitchell P, Cheung N, de Haseth K, et al. Blood pressure and retinal arteriolar narrowing in children. Hypertension. 2007;49:1156–62.PubMedCrossRef Mitchell P, Cheung N, de Haseth K, et al. Blood pressure and retinal arteriolar narrowing in children. Hypertension. 2007;49:1156–62.PubMedCrossRef
71.
go back to reference Li S, Chen W, Srinivasan SR, et al. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA. 2003;290:2271–6.PubMedCrossRef Li S, Chen W, Srinivasan SR, et al. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA. 2003;290:2271–6.PubMedCrossRef
72.
go back to reference Raitakari OT, Juonala M, Kahonen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290:2277–83.PubMedCrossRef Raitakari OT, Juonala M, Kahonen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290:2277–83.PubMedCrossRef
73.
go back to reference Berenson GS, Srinivasan SR, Bao W, et al. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998;338:1650–6.PubMedCrossRef Berenson GS, Srinivasan SR, Bao W, et al. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998;338:1650–6.PubMedCrossRef
74.
go back to reference Li S, Chen W, Srinivasan SR, Berenson GS. Childhood blood pressure as a predictor of arterial stiffness in young adults: the bogalusa heart study. Hypertension. 2004;43:541–6.PubMedCrossRef Li S, Chen W, Srinivasan SR, Berenson GS. Childhood blood pressure as a predictor of arterial stiffness in young adults: the bogalusa heart study. Hypertension. 2004;43:541–6.PubMedCrossRef
75.
go back to reference Simonetti GD, Vonv RO, Wuhl E, Mohaupt MG. Ambulatory arterial stiffness index is increased in hypertensive childhood disease. Pediatr Res. 2008;64:303–7.PubMedCrossRef Simonetti GD, Vonv RO, Wuhl E, Mohaupt MG. Ambulatory arterial stiffness index is increased in hypertensive childhood disease. Pediatr Res. 2008;64:303–7.PubMedCrossRef
76.
go back to reference Lande MB, Kaczorowski JM, Auinger P, et al. Elevated blood pressure and decreased cognitive function among school-age children and adolescents in the United States. J Pediatr. 2003;143:720–4.PubMedCrossRef Lande MB, Kaczorowski JM, Auinger P, et al. Elevated blood pressure and decreased cognitive function among school-age children and adolescents in the United States. J Pediatr. 2003;143:720–4.PubMedCrossRef
77.
go back to reference •• Lande MB, Kupferman JC, Adams HR. Neurocognitive alterations in hypertensive children and adolescents. J Clin Hypertens (Greenwich). 2012;14:353–9. This article reviews the evidence that children with hypertension manifest neurocognitive differences when compared with normotensive controls. Several studies suggest that children with hypertension manifest deficits on measures of neurocognition and have an increased prevalence of learning difficulties, and that children with hypertension associated with obesity may be at increased risk for depression and anxiety.CrossRef •• Lande MB, Kupferman JC, Adams HR. Neurocognitive alterations in hypertensive children and adolescents. J Clin Hypertens (Greenwich). 2012;14:353–9. This article reviews the evidence that children with hypertension manifest neurocognitive differences when compared with normotensive controls. Several studies suggest that children with hypertension manifest deficits on measures of neurocognition and have an increased prevalence of learning difficulties, and that children with hypertension associated with obesity may be at increased risk for depression and anxiety.CrossRef
78.
go back to reference Adams HR, Szilagyi PG, Gebhardt L, Lande MB. Learning and attention problems among children with pediatric primary hypertension. Pediatrics. 2010;126:e1425–9.PubMedCrossRef Adams HR, Szilagyi PG, Gebhardt L, Lande MB. Learning and attention problems among children with pediatric primary hypertension. Pediatrics. 2010;126:e1425–9.PubMedCrossRef
79.
go back to reference Wong LJ, Kupferman JC, Prohovnik I, et al. Hypertension impairs vascular reactivity in the pediatric brain. Stroke. 2011;42:1834–8.PubMedCrossRef Wong LJ, Kupferman JC, Prohovnik I, et al. Hypertension impairs vascular reactivity in the pediatric brain. Stroke. 2011;42:1834–8.PubMedCrossRef
80.
go back to reference Seeman T, Pohl M, Palyzova D, John U. Microalbuminuria in children with primary and white-coat hypertension. Pediatr Nephrol. 2012;27:461–7.PubMedCrossRef Seeman T, Pohl M, Palyzova D, John U. Microalbuminuria in children with primary and white-coat hypertension. Pediatr Nephrol. 2012;27:461–7.PubMedCrossRef
81.
go back to reference Hanevold CD, Pollock JS, Harshfield GA. Racial differences in microalbumin excretion in healthy adolescents. Hypertension. 2008;51:334–8.PubMedCrossRef Hanevold CD, Pollock JS, Harshfield GA. Racial differences in microalbumin excretion in healthy adolescents. Hypertension. 2008;51:334–8.PubMedCrossRef
82.
go back to reference Nguyen S, McCulloch C, Brakeman P, et al. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008;121:37–45.PubMedCrossRef Nguyen S, McCulloch C, Brakeman P, et al. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008;121:37–45.PubMedCrossRef
83.
go back to reference Bibbins-Domingo K, Coxson P, Pletcher MJ, et al. Adolescent overweight and future adult coronary heart disease. N Engl J Med. 2007;357:2371–9.PubMedCrossRef Bibbins-Domingo K, Coxson P, Pletcher MJ, et al. Adolescent overweight and future adult coronary heart disease. N Engl J Med. 2007;357:2371–9.PubMedCrossRef
84.
go back to reference Daniels SR. Is there an epidemic of cardiovascular disease on the horizon? J Pediatr. 1999;134:665–6.PubMedCrossRef Daniels SR. Is there an epidemic of cardiovascular disease on the horizon? J Pediatr. 1999;134:665–6.PubMedCrossRef
Metadata
Title
Primary Hypertension in Childhood
Authors
Barbara S. Bucher
Alessandra Ferrarini
Nico Weber
Marina Bullo
Mario G. Bianchetti
Giacomo D. Simonetti
Publication date
01-10-2013
Publisher
Springer US
Published in
Current Hypertension Reports / Issue 5/2013
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI
https://doi.org/10.1007/s11906-013-0378-8

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