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Current HIV/AIDS Reports
Published in: Current HIV/AIDS Reports 2/2020

01-04-2020 | Pharmacokinetics | HIV Pathogenesis and Treatment (AL Landay and NS Utay, Section Editors)

Novel Antiretroviral Agents

Authors: Mary C. Cambou, Raphael J. Landovitz

Published in: Current HIV/AIDS Reports | Issue 2/2020

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Abstract

Purpose of Review

Combination antiretroviral therapy (cART) has had dramatic effects on morbidity and mortality for persons living with HIV (PLWH). Despite significant progress in treatment efficacy, tolerability, and reducing pill burden, new agents are needed to address issues of resistance, drug-drug interactions, end organ disease, and adherence. This review covers novel ART agents recently approved or in development.

Recent Findings

Capsid inhibitors (CAI) demonstrate high potency and potential for extended-duration dosing in pre-clinical trials. While previous maturation inhibitors (MI) were hampered by issues of drug resistance, a recent phase IIa trial for a second-generation MI demonstrated promising antiviral activity. A phase I trial to evaluate a transdermal implant of islatravir, a nucleoside reverse transcriptase translocation inhibitor (NRTTI), maintained concentrations above the target pharmacokinetic threshold at 12 weeks. The attachment inhibitor fostemsavir is available in the USA for compassionate use in multi-drug-resistant (MDR) HIV.

Summary

New antiretroviral agents show promise for both extended-duration dosing and MDR HIV.
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Metadata
Title
Novel Antiretroviral Agents
Authors
Mary C. Cambou
Raphael J. Landovitz
Publication date
01-04-2020
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 2/2020
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-020-00486-2

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