Skip to main content
Top
Published in: Current Cardiology Reports 2/2012

01-04-2012 | Nuclear Cardiology (V Dilsizian, Section Editor)

Advances in Nuclear Cardiac Instrumentation with a View Towards Reduced Radiation Exposure

Authors: Piotr J. Slomka, Damini Dey, W. Lane Duvall, Milena J. Henzlova, Daniel S. Berman, Guido Germano

Published in: Current Cardiology Reports | Issue 2/2012

Login to get access

Abstract

Recent advances in nuclear cardiology instrumentation have enabled myocardial perfusion imaging (MPI) with improved image quality and faster scan times. These developments also can be exploited to reduce the effective radiation dose to the patient. In this review, we discuss these technologies including new single photon emission computed tomography (SPECT) and positron emission tomography (PET) scanners, as well as novel reconstruction software with regard to their potential for the reduction of the patient radiation dose. New advances in nuclear cardiology instrumentation will allow routine rest/stress MPI imaging with low radiation doses (<5 mSv) and fast imaging times, even by the software-only solutions. It is possible to further reduce the MPI radiation dose to less than 2 to 3 mSv range with standard acquisition times. PET perfusion imaging also can be performed with very low doses especially by the three-dimensional scanners allowing hybrid PET/computed tomographic angiography (CTA) imaging with low overall dose. In addition, stress-only protocols can be utilized to further reduce the radiation dose and the overall test time.
Literature
1.
go back to reference • Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol. 2009;16(2):255–76. This is an in depth-review of the new technologies for MPI. PubMedCrossRef Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol. 2009;16(2):255–76. This is an in depth-review of the new technologies for MPI. PubMedCrossRef
2.
go back to reference Tubiana M, Feinendegen LE, Yang C, Kaminski JM. The linear no-threshold relationship is inconsistent with radiation biologic and experimental data. Radiology. 2009;251(1):13–22.PubMedCrossRef Tubiana M, Feinendegen LE, Yang C, Kaminski JM. The linear no-threshold relationship is inconsistent with radiation biologic and experimental data. Radiology. 2009;251(1):13–22.PubMedCrossRef
3.
go back to reference Laskey WK, Feinendegen LE, Neumann RD, Dilsizian V. Low-level ionizing radiation from noninvasive cardiac imaging: can we extrapolate estimated risks from epidemiologic data to the clinical setting? JACC Cardiovasc Imaging. 2010;3(5):517–24.PubMedCrossRef Laskey WK, Feinendegen LE, Neumann RD, Dilsizian V. Low-level ionizing radiation from noninvasive cardiac imaging: can we extrapolate estimated risks from epidemiologic data to the clinical setting? JACC Cardiovasc Imaging. 2010;3(5):517–24.PubMedCrossRef
4.
go back to reference Gunter DL. Gamma Camera Collimator Characteristics and Design. In: Henkin RE, editor. Nuclear Medicine, vol. 1. Philadelphia, PA: Elsevier; 2006. p. 107–26. Gunter DL. Gamma Camera Collimator Characteristics and Design. In: Henkin RE, editor. Nuclear Medicine, vol. 1. Philadelphia, PA: Elsevier; 2006. p. 107–26.
5.
go back to reference Sharir T, Slomka P, Hayes S, et al. Multicenter trial of high-speed vs. Conventional SPECT Imaging:Quantitive Results of Myocardial Perfusion and Left Ventricular function. J Am Coll Cardiol. 2010;4;55(18):1965–74. Sharir T, Slomka P, Hayes S, et al. Multicenter trial of high-speed vs. Conventional SPECT Imaging:Quantitive Results of Myocardial Perfusion and Left Ventricular function. J Am Coll Cardiol. 2010;4;55(18):1965–74.
6.
go back to reference Maddahi J, Mendez R, Mahmarian JJ, et al. Prospective multicenter evaluation of rapid, gated SPECT myocardial perfusion upright imaging. J Nucl Cardiol. 2009;16(3):351–7.PubMedCrossRef Maddahi J, Mendez R, Mahmarian JJ, et al. Prospective multicenter evaluation of rapid, gated SPECT myocardial perfusion upright imaging. J Nucl Cardiol. 2009;16(3):351–7.PubMedCrossRef
7.
go back to reference Sharir T, Ben-Haim S, Merzon K, et al. High-speed myocardial perfusion imaging: Initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovascular Imaging. 2008;1(2):156–63.PubMedCrossRef Sharir T, Ben-Haim S, Merzon K, et al. High-speed myocardial perfusion imaging: Initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovascular Imaging. 2008;1(2):156–63.PubMedCrossRef
8.
go back to reference Jaszczak RJ, Li J, Wang H, Zalutsky MR, Coleman RE. Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Phys Med Biol. 1994;39:425–37.PubMedCrossRef Jaszczak RJ, Li J, Wang H, Zalutsky MR, Coleman RE. Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Phys Med Biol. 1994;39:425–37.PubMedCrossRef
9.
go back to reference Schramm NU, Ebel G, Engeland U, Schurrat T, Behe M, Behr TM. High-resolution SPECT using multipinhole collimation. Nuclear Science, IEEE Transactions on. 2003;50(3):315–20.CrossRef Schramm NU, Ebel G, Engeland U, Schurrat T, Behe M, Behr TM. High-resolution SPECT using multipinhole collimation. Nuclear Science, IEEE Transactions on. 2003;50(3):315–20.CrossRef
10.
go back to reference Beekman FJ, Vastenhouw B. Design and simulation of a high-resolution stationary SPECT system for small animals. Phys Med Biol. 2004;49(19):4579–92.PubMedCrossRef Beekman FJ, Vastenhouw B. Design and simulation of a high-resolution stationary SPECT system for small animals. Phys Med Biol. 2004;49(19):4579–92.PubMedCrossRef
11.
go back to reference Volokh L, Hugg J, Blevis I, Asma E, Jansen F, Manjeshwar R. Effect of detector energy response on image quality of myocardial perfusion SPECT. Paper presented at: IEEE Nuclear Science Symposium and Medical Imaging conference; 19–26, 2008; Dresden. Volokh L, Hugg J, Blevis I, Asma E, Jansen F, Manjeshwar R. Effect of detector energy response on image quality of myocardial perfusion SPECT. Paper presented at: IEEE Nuclear Science Symposium and Medical Imaging conference; 19–26, 2008; Dresden.
12.
go back to reference Herzog BA, Buechel RR, Husmann L, et al. Validation of CT attenuation correction for high-speed myocardial perfusion imaging using a novel cadmium-zinc-telluride detector technique. J Nucl Med. 2010;51(10):1539–44.PubMedCrossRef Herzog BA, Buechel RR, Husmann L, et al. Validation of CT attenuation correction for high-speed myocardial perfusion imaging using a novel cadmium-zinc-telluride detector technique. J Nucl Med. 2010;51(10):1539–44.PubMedCrossRef
13.
go back to reference Slomka P, Berman D, Germano G. New imaging protocols for new single photon emission CT technologies. Curr Cardiovasc Imaging Rep. 2010;3(3):162–70.PubMedCrossRef Slomka P, Berman D, Germano G. New imaging protocols for new single photon emission CT technologies. Curr Cardiovasc Imaging Rep. 2010;3(3):162–70.PubMedCrossRef
14.
go back to reference Lau YH, Hutton BF, Beekman FJ. Choice of collimator for cardiac SPET when resolution compensation is included in iterative reconstruction. Eur J Nucl Med. 2001;28(1):39–47.PubMedCrossRef Lau YH, Hutton BF, Beekman FJ. Choice of collimator for cardiac SPET when resolution compensation is included in iterative reconstruction. Eur J Nucl Med. 2001;28(1):39–47.PubMedCrossRef
15.
go back to reference Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets ofprojection data. Medical Imaging, IEEE Transactions on. 1994;13(4):601–9.CrossRef Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets ofprojection data. Medical Imaging, IEEE Transactions on. 1994;13(4):601–9.CrossRef
17.
go back to reference Borges-Neto SPR, Shaw LK, et al. Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies. J Nucl Cardiol. 2007;14:555–65.PubMedCrossRef Borges-Neto SPR, Shaw LK, et al. Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies. J Nucl Cardiol. 2007;14:555–65.PubMedCrossRef
18.
go back to reference • DePuey EG, Bommireddipalli S, Clark J, Thompson L, Srour Y. Wide beam reconstruction “quarter-time” gated myocardial perfusion SPECT functional imaging: a comparison to “full-time” ordered subset expectation maximum. J Nucl Cardiol. 2009;16(5):736–52. Software-only reconstruction improvement allows quarter-time acqusition of the data obtained on the standard SPECT camera. PubMedCrossRef DePuey EG, Bommireddipalli S, Clark J, Thompson L, Srour Y. Wide beam reconstruction “quarter-time” gated myocardial perfusion SPECT functional imaging: a comparison to “full-time” ordered subset expectation maximum. J Nucl Cardiol. 2009;16(5):736–52. Software-only reconstruction improvement allows quarter-time acqusition of the data obtained on the standard SPECT camera. PubMedCrossRef
19.
go back to reference Vija H, Chapman J, Ray M. IQ•SPECT technology White Paper. Siemens Medical Solutions USA Molecular Imaging; 2008:1–7. Vija H, Chapman J, Ray M. IQ•SPECT technology White Paper. Siemens Medical Solutions USA Molecular Imaging; 2008:1–7.
20.
go back to reference Bateman TM, Heller GV, McGhie AI, et al. Multicenter investigation comparing a highly efficient half-time stress-only attenuation correction approach against standard rest-stress Tc-99 m SPECT imaging. J Nucl Cardiol. 2009;16(5):726–35.PubMedCrossRef Bateman TM, Heller GV, McGhie AI, et al. Multicenter investigation comparing a highly efficient half-time stress-only attenuation correction approach against standard rest-stress Tc-99 m SPECT imaging. J Nucl Cardiol. 2009;16(5):726–35.PubMedCrossRef
21.
go back to reference Valenta I, Treyer V, Husmann L, et al. New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT. Eur J Nucl Med Mol Imaging. 2010;37(4):750–7.PubMedCrossRef Valenta I, Treyer V, Husmann L, et al. New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT. Eur J Nucl Med Mol Imaging. 2010;37(4):750–7.PubMedCrossRef
22.
go back to reference Gutstein A, Solodky A, Mats I, et al. Feasibility of myocardial perfusion SPECT with prone and half-time imaging. Nucl Med Commun. 2011;32(5):386–91. Gutstein A, Solodky A, Mats I, et al. Feasibility of myocardial perfusion SPECT with prone and half-time imaging. Nucl Med Commun. 2011;32(5):386–91.
23.
go back to reference Ali I, Ruddy TD, Almgrahi A, Anstett FG, Wells RG. Half-Time SPECT Myocardial Perfusion Imaging with Attenuation Correction. J Nucl Med. 2009;50(4):554–62.PubMedCrossRef Ali I, Ruddy TD, Almgrahi A, Anstett FG, Wells RG. Half-Time SPECT Myocardial Perfusion Imaging with Attenuation Correction. J Nucl Med. 2009;50(4):554–62.PubMedCrossRef
24.
go back to reference Henzlova M, Duvall W. The future of SPECT MPI: Time and dose reduction. J Nucl Cardiol. 2011;18(4):580–7.PubMedCrossRef Henzlova M, Duvall W. The future of SPECT MPI: Time and dose reduction. J Nucl Cardiol. 2011;18(4):580–7.PubMedCrossRef
25.
go back to reference Duvall W, Croft L, Godiwala T, Ginsberg E, George T, Henzlova M. Reduced isotope dose with rapid SPECT MPI imaging: Initial experience with a CZT SPECT camera. J Nucl Cardiol. 2010;17(6):1009–14.PubMedCrossRef Duvall W, Croft L, Godiwala T, Ginsberg E, George T, Henzlova M. Reduced isotope dose with rapid SPECT MPI imaging: Initial experience with a CZT SPECT camera. J Nucl Cardiol. 2010;17(6):1009–14.PubMedCrossRef
26.
go back to reference • Duvall W, Croft L, Ginsberg E, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18(5):847–57. This is a clinical demonstration of the low-dose imaging with the new multi-pinhole camera. PubMedCrossRef Duvall W, Croft L, Ginsberg E, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18(5):847–57. This is a clinical demonstration of the low-dose imaging with the new multi-pinhole camera. PubMedCrossRef
27.
go back to reference Gimelli A, Bottai M, Genovesi D, Giorgetti A, Di Martino F, Marzullo P. High diagnostic accuracy of low-dose gated-SPECT with solid-state ultrafast detectors: preliminary clinical results. Eur J Nucl Med Mol Imaging. 2012;39(1):83–90. Gimelli A, Bottai M, Genovesi D, Giorgetti A, Di Martino F, Marzullo P. High diagnostic accuracy of low-dose gated-SPECT with solid-state ultrafast detectors: preliminary clinical results. Eur J Nucl Med Mol Imaging. 2012;39(1):83–90.
28.
go back to reference DePuey E, Bommireddipalli S, Clark J, Leykekhman A, Thompson L, Friedman M. A comparison of the image quality of full-time myocardial perfusion SPECT vs wide beam reconstruction half-time and half-dose SPECT. J Nucl Cardiol. 2011;18(2):273–80.PubMedCrossRef DePuey E, Bommireddipalli S, Clark J, Leykekhman A, Thompson L, Friedman M. A comparison of the image quality of full-time myocardial perfusion SPECT vs wide beam reconstruction half-time and half-dose SPECT. J Nucl Cardiol. 2011;18(2):273–80.PubMedCrossRef
29.
go back to reference Nkoulou R, Pazhenkottil AP, Kuest SM, et al. Semiconductor Detectors Allow Low-Dose–Low-Dose 1-Day SPECT Myocardial Perfusion Imaging. J Nucl Med. 2011;52(8):1204–9.PubMedCrossRef Nkoulou R, Pazhenkottil AP, Kuest SM, et al. Semiconductor Detectors Allow Low-Dose–Low-Dose 1-Day SPECT Myocardial Perfusion Imaging. J Nucl Med. 2011;52(8):1204–9.PubMedCrossRef
30.
go back to reference Berman DS, Kang X, Tamarappoo B, et al. Stress thallium-201/rest technetium-99 m sequential dual isotope high-speed myocardial perfusion imaging. JACC: Cardiovascular Imaging. 2009;2(3):273–82.PubMedCrossRef Berman DS, Kang X, Tamarappoo B, et al. Stress thallium-201/rest technetium-99 m sequential dual isotope high-speed myocardial perfusion imaging. JACC: Cardiovascular Imaging. 2009;2(3):273–82.PubMedCrossRef
31.
go back to reference Germano G, Slomka PJ, Berman DS. Attenuation correction in cardiac SPECT: the boy who cried wolf? J Nucl Cardiol. 2007;14(1):25–35.PubMedCrossRef Germano G, Slomka PJ, Berman DS. Attenuation correction in cardiac SPECT: the boy who cried wolf? J Nucl Cardiol. 2007;14(1):25–35.PubMedCrossRef
32.
go back to reference Einstein AJ, Johnson LL, Bokhari S, et al. Agreement of Visual Estimation of Coronary Artery Calcium From Low-Dose CT Attenuation Correction Scans in Hybrid PET/CT and SPECT/CT With Standard Agatston Score. J Am Coll Cardiol. 2010;56(23):1914–21.PubMedCrossRef Einstein AJ, Johnson LL, Bokhari S, et al. Agreement of Visual Estimation of Coronary Artery Calcium From Low-Dose CT Attenuation Correction Scans in Hybrid PET/CT and SPECT/CT With Standard Agatston Score. J Am Coll Cardiol. 2010;56(23):1914–21.PubMedCrossRef
33.
go back to reference Bai C, Conwell R, Kindem J, et al. Phantom evaluation of a cardiac SPECT/VCT system that uses a common set of solid-state detectors for both emission and transmission scans. J Nucl Cardiol. 2010;17(3):459–69.PubMedCrossRef Bai C, Conwell R, Kindem J, et al. Phantom evaluation of a cardiac SPECT/VCT system that uses a common set of solid-state detectors for both emission and transmission scans. J Nucl Cardiol. 2010;17(3):459–69.PubMedCrossRef
34.
go back to reference Mahmarian JJ. Stress only myocardial perfusion imaging: Is it time for a change? J Nucl Cardiol. 2010;17(4):529–35.PubMedCrossRef Mahmarian JJ. Stress only myocardial perfusion imaging: Is it time for a change? J Nucl Cardiol. 2010;17(4):529–35.PubMedCrossRef
35.
go back to reference Duvall WL, Wijetunga MN, Klein TM, et al. The prognosis of a normal stress-only Tc-99 m myocardial perfusion imaging study. J Nucl Cardiol. 2010;17(3):370–7.PubMedCrossRef Duvall WL, Wijetunga MN, Klein TM, et al. The prognosis of a normal stress-only Tc-99 m myocardial perfusion imaging study. J Nucl Cardiol. 2010;17(3):370–7.PubMedCrossRef
36.
go back to reference Duvall WL, Wijetunga MN, Klein TM, et al. Stress-Only Tc-99 m Myocardial Perfusion Imaging in an Emergency Department Chest Pain Unit. J Emerg Med. Aug 27 2011 (in press). Duvall WL, Wijetunga MN, Klein TM, et al. Stress-Only Tc-99 m Myocardial Perfusion Imaging in an Emergency Department Chest Pain Unit. J Emerg Med. Aug 27 2011 (in press).
37.
go back to reference Chang SM, Nabi F, Xu J, Raza U, Mahmarian JJ. Normal stress-only versus standard stress/rest myocardial perfusion imaging: Similar patient mortality with reduced radiation exposure. J Am Coll Cardiol. 2010;55(3):221–30.PubMedCrossRef Chang SM, Nabi F, Xu J, Raza U, Mahmarian JJ. Normal stress-only versus standard stress/rest myocardial perfusion imaging: Similar patient mortality with reduced radiation exposure. J Am Coll Cardiol. 2010;55(3):221–30.PubMedCrossRef
38.
go back to reference •• Nakazato R, Tamarappoo BK, Kang X, et al. Quantitative upright-supine high-speed SPECT myocardial perfusion imaging for detection of coronary artery disease: correlation with invasive coronary angiography. J Nucl Med. Nov 2010;51(11):1724–31. This is a fully quantitive analysis of supine and upright MPI data from the new fast SPECT system with angiographic validation. PubMedCrossRef •• Nakazato R, Tamarappoo BK, Kang X, et al. Quantitative upright-supine high-speed SPECT myocardial perfusion imaging for detection of coronary artery disease: correlation with invasive coronary angiography. J Nucl Med. Nov 2010;51(11):1724–31. This is a fully quantitive analysis of supine and upright MPI data from the new fast SPECT system with angiographic validation. PubMedCrossRef
39.
go back to reference Nishina H, Slomka PJ, Abidov A, et al. Combined supine and prone quantitative myocardial perfusion SPECT: method development and clinical validation in patients with no known coronary artery disease. J Nucl Med. 2006;47(1):51–8.PubMed Nishina H, Slomka PJ, Abidov A, et al. Combined supine and prone quantitative myocardial perfusion SPECT: method development and clinical validation in patients with no known coronary artery disease. J Nucl Med. 2006;47(1):51–8.PubMed
40.
go back to reference Husmann L, Herzog BA, Gaemperli O, et al. Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: comparison of prospective electrocardiogram-triggering vs. retrospective gating. Eur Hear J. 2009;30(5):600.CrossRef Husmann L, Herzog BA, Gaemperli O, et al. Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: comparison of prospective electrocardiogram-triggering vs. retrospective gating. Eur Hear J. 2009;30(5):600.CrossRef
41.
go back to reference Klein R, Beanlands R, deKemp R. Quantification of myocardial blood flow and flow reserve: Technical aspects. J Nucl Cardiol. 2010;17(4):555–70.PubMedCrossRef Klein R, Beanlands R, deKemp R. Quantification of myocardial blood flow and flow reserve: Technical aspects. J Nucl Cardiol. 2010;17(4):555–70.PubMedCrossRef
42.
go back to reference Esteves F, Nye J, Khan A, et al. Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT. J Nucl Cardiol. 2010;17(2):247–53.PubMedCrossRef Esteves F, Nye J, Khan A, et al. Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT. J Nucl Cardiol. 2010;17(2):247–53.PubMedCrossRef
43.
go back to reference Knešaurek K, Machac J, Krynyckyi BR, Almeida OD. Comparison of 2-Dimensional and 3-Dimensional 82Rb Myocardial Perfusion PET Imaging. J Nucl Med. 2003;44(8):1350–6.PubMed Knešaurek K, Machac J, Krynyckyi BR, Almeida OD. Comparison of 2-Dimensional and 3-Dimensional 82Rb Myocardial Perfusion PET Imaging. J Nucl Med. 2003;44(8):1350–6.PubMed
44.
go back to reference Jakoby BW, Bercier Y, Conti M, Casey ME, Bendriem B, Townsend DW. Physical and clinical performance of the mCT time-of-flight PET/CT scanner. Phys Med Biol. 2011;56(8):2375–89.PubMedCrossRef Jakoby BW, Bercier Y, Conti M, Casey ME, Bendriem B, Townsend DW. Physical and clinical performance of the mCT time-of-flight PET/CT scanner. Phys Med Biol. 2011;56(8):2375–89.PubMedCrossRef
45.
go back to reference Panin VY, Kehren F, Michel C, Casey M. Fully 3-D PET reconstruction with system matrix derived from point source measurements. IEEE Trans Med Imaging. 2006;25(7):907–21.PubMedCrossRef Panin VY, Kehren F, Michel C, Casey M. Fully 3-D PET reconstruction with system matrix derived from point source measurements. IEEE Trans Med Imaging. 2006;25(7):907–21.PubMedCrossRef
46.
go back to reference Le Meunier L, Slomka P, Dey D, et al. Enhanced definition PET for cardiac imaging. J Nucl Cardiol. 2010;17(3):414–26.PubMedCrossRef Le Meunier L, Slomka P, Dey D, et al. Enhanced definition PET for cardiac imaging. J Nucl Cardiol. 2010;17(3):414–26.PubMedCrossRef
47.
go back to reference Le Meunier L, Slomka PJ, Dey D, et al. Motion frozen (18)F-FDG cardiac PET. J Nucl Cardiol. 2011;18(2):259–66.PubMedCrossRef Le Meunier L, Slomka PJ, Dey D, et al. Motion frozen (18)F-FDG cardiac PET. J Nucl Cardiol. 2011;18(2):259–66.PubMedCrossRef
48.
go back to reference Slomka PJ, Nishina H, Berman DS, et al. “Motion-frozen” display and quantification of myocardial perfusion. J Nucl Med. 2004;45(7):1128–34.PubMed Slomka PJ, Nishina H, Berman DS, et al. “Motion-frozen” display and quantification of myocardial perfusion. J Nucl Med. 2004;45(7):1128–34.PubMed
49.
go back to reference Di Carli MF, Dorbala S, Meserve J, El Fakhri G, Sitek A, Moore SC. Clinical myocardial perfusion PET/CT. J Nucl Med. 2007;48(5):783–93.PubMedCrossRef Di Carli MF, Dorbala S, Meserve J, El Fakhri G, Sitek A, Moore SC. Clinical myocardial perfusion PET/CT. J Nucl Med. 2007;48(5):783–93.PubMedCrossRef
50.
go back to reference Schwaiger M, Ziegler SI, Nekolla SG. PET/CT challenge for the non-invasive diagnosis of coronary artery disease. Eur J Radiol. 2010;73(3):494–503.PubMedCrossRef Schwaiger M, Ziegler SI, Nekolla SG. PET/CT challenge for the non-invasive diagnosis of coronary artery disease. Eur J Radiol. 2010;73(3):494–503.PubMedCrossRef
51.
go back to reference Senthamizhchelvan S, Bravo PE, Esaias C, et al. Human Biodistribution and Radiation Dosimetry of 82Rb. J Nucl Med. 2010;51(10):1592–9.PubMedCrossRef Senthamizhchelvan S, Bravo PE, Esaias C, et al. Human Biodistribution and Radiation Dosimetry of 82Rb. J Nucl Med. 2010;51(10):1592–9.PubMedCrossRef
52.
go back to reference Knuuti J. Integrated positron emission tomography/computed tomography (PET/CT) in coronary disease. Heart. 2009;95(17):1457–63.PubMedCrossRef Knuuti J. Integrated positron emission tomography/computed tomography (PET/CT) in coronary disease. Heart. 2009;95(17):1457–63.PubMedCrossRef
53.
go back to reference Kajander S, Joutsiniemi E, Saraste M, et al. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease/Clinical Perspective. Circulation. 2010;122(6):603–13.PubMedCrossRef Kajander S, Joutsiniemi E, Saraste M, et al. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease/Clinical Perspective. Circulation. 2010;122(6):603–13.PubMedCrossRef
54.
go back to reference Herzog BA, Buechel RR, Katz R, et al. Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: Optimized protocol for scan time reduction. J Nucl Med. 2010;51(1):46–51.PubMedCrossRef Herzog BA, Buechel RR, Katz R, et al. Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: Optimized protocol for scan time reduction. J Nucl Med. 2010;51(1):46–51.PubMedCrossRef
55.
go back to reference Buechel RR, Herzog BA, Husmann L, et al. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation. Eur J Nucl Med Mol Imaging. 2010;37(4):773–78. Buechel RR, Herzog BA, Husmann L, et al. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation. Eur J Nucl Med Mol Imaging. 2010;37(4):773–78.
56.
go back to reference Esteves FP, Raggi P, Folks RD, et al. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras. J Nucl Cardiol. 2009;16:927–34.PubMedCrossRef Esteves FP, Raggi P, Folks RD, et al. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras. J Nucl Cardiol. 2009;16:927–34.PubMedCrossRef
57.
go back to reference Fiechter M, Ghadri J, Kuest S, et al. Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography. Eur J Nucl Med Mol Imaging. 2011;38(11):2025–30.PubMedCrossRef Fiechter M, Ghadri J, Kuest S, et al. Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography. Eur J Nucl Med Mol Imaging. 2011;38(11):2025–30.PubMedCrossRef
58.
go back to reference Venero CV, Heller GV, Bateman TM, et al. A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol. 2009;16(5):714–25.PubMedCrossRef Venero CV, Heller GV, Bateman TM, et al. A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol. 2009;16(5):714–25.PubMedCrossRef
59.
go back to reference Gimelli A, Bottai M, Giorgetti A, et al. Comparison between ultrafast and standard single-photon emission CT in patients with coronary artery disease: a pilot study. Circ Cardiovasc Imaging. 2011;4(1):51–8.PubMedCrossRef Gimelli A, Bottai M, Giorgetti A, et al. Comparison between ultrafast and standard single-photon emission CT in patients with coronary artery disease: a pilot study. Circ Cardiovasc Imaging. 2011;4(1):51–8.PubMedCrossRef
Metadata
Title
Advances in Nuclear Cardiac Instrumentation with a View Towards Reduced Radiation Exposure
Authors
Piotr J. Slomka
Damini Dey
W. Lane Duvall
Milena J. Henzlova
Daniel S. Berman
Guido Germano
Publication date
01-04-2012
Publisher
Current Science Inc.
Published in
Current Cardiology Reports / Issue 2/2012
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-012-0248-z

Other articles of this Issue 2/2012

Current Cardiology Reports 2/2012 Go to the issue

Valvular Heart Disease (V Nkomo, Section Editor)

Minimally Invasive Heart Valve Surgery: How and Why in 2012

Peripheral Vascular Disease (M Shishehbor, Section Editor)

Renal Intervention to Treat Hypertension

Valvular Heart Disease (V Nkomo, Section Editor)

Tricuspid Regurgitation: Pathophysiology and Management