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Open Access 01-06-2010

New Imaging Protocols for New Single Photon Emission CT Technologies

Authors: Piotr J. Slomka, Daniel S. Berman, Guido Germano

Published in: Current Cardiovascular Imaging Reports | Issue 3/2010

Abstract

Nuclear cardiology practitioners have several new technologies available with which to perform myocardial perfusion single photon emission CT (MPS). These include dedicated small-footprint cardiac scanners, new stationary or semi-stationary three-dimensional detectors, and advanced software algorithms for optimal image reconstruction. These new technologies have been employed to reduce imaging time and radiation exposure. They require less technologist and camera time and offer improved patient comfort. They have potential for the overall cost reduction of MPS and at the same time for improved accuracy by increased resolution, or accurate attenuation correction. Furthermore, these new technologies offer potential for new protocols such as simultaneous dual isotope, new combinations of isotopes, stress only MPS, or dynamic first-pass imaging. In addition, new imaging technologies in coronary CT angiography (CCTA) allow novel hybrid stress only MPS/CCTA protocols with reduced radiation burden. Additional developments further improving efficiency and diagnostic accuracy of MPS are on the horizon.

Dilsizian V, Narula J: Atlas of Nuclear Cardiology, edn 3. Springer; Philadelphia, PA: 2009.

• Slomka PJ, Patton JA, Berman DS, Germano G: Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol 2009, 16:255–276. This is a comprehensive review of the technical aspects of the new systems and software.CrossRefPubMed

Lewin HC, Hyun MC: A clinical comparison of an upright triple-head digital detector system to a standard supine dual-head gamma camera [abstract]. J Nucl Cardiol 2005, 12:113.CrossRef

www.CardiArc.com. Accessed May 30, 2008.

Jaszczak RJ, Li J, Wang H, et al.: Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Phys Med Biol 1994, 39:425–437.CrossRefPubMed

Schramm NU, Ebel G, Engeland U, et al.: High-resolution SPECT using multipinhole collimation. IEEE Transactions on Nuclear Science 2003, 50:315–320.CrossRef

Beekman FJ, Vastenhouw B: Design and simulation of a high-resolution stationary SPECT system for small animals. Phys Med Biol 2004, 49:4579–4592.CrossRefPubMed

Volokh L, Hugg J, Blevis I, et al.: Effect of detector energy response on image quality of myocardial perfusion SPECT. Paper presented at IEEE Nuclear Science Symposium and Medical Imaging Conference. Dresden, Germany; October 19–26, 2008.

Vija H, Chapman J, Ray M: IQ•SPECT technology White Paper. Siemens Medical Solutions USA Molecular Imaging; 2008:1–7.

10.

Hudson HM, Larkin RS: Accelerated image reconstruction using ordered subsets of projection data. IEEE Transactions on Medical Imaging 1994, 13:601–609.CrossRefPubMed

11.

Ultraspect. www.UltraSPECT.com. Accessed September 6, 2008.

12.

Borges-Neto S, Pagnanelli RA, Shaw LK, et al.: Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies. J Nucl Cardiol 2007, 14:555–565.CrossRefPubMed

13.

Herzog BA, Buechel RR, Katz R, et al.: Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: optimized protocol for scan time reduction. J Nucl Med 2010, 51:46–51.CrossRefPubMed

14.

Buechel RR, Herzog BA, Husmann L, et al.: Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation. Eur J Nucl Med Mol Imaging 2009, In press.

15.

• Esteves FP, Raggi P, Folks RD, et al.: Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras. J Nucl Cardiol 2009, 16:927–934. This is the first clinical US study of the new multi-pinhole detector system.CrossRefPubMed

16.

Sharir T, Ben-Haim S, Merzon K, et al.: High-speed myocardial perfusion imaging: initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovasc Imaging 2008, 1:156–163.CrossRefPubMed

17.

• Berman DS, Kang X, Tamarappoo B, et al.: Stress thallium-201/rest technetium-99m sequential dual isotope high-speed myocardial perfusion imaging. JACC Cardiovasc Imaging 2009, 2:273–282. This is a novel Tl/Tc protocol for dose-efficient fast stress and rest MPS scanning.CrossRefPubMed

18.

Nishina H, Slomka PJ, Abidov A, et al.: Combined supine and prone quantitative myocardial perfusion SPECT: method development and clinical validation in patients with no known coronary artery disease. J Nucl Med 2006, 47:51–58.PubMed

19.

•• Sharir T, Slomka P, Hayes S, et al.: Multicenter trial of high-speed vs. conventional SPECT imaging: quantitative results of myocardial perfusion and left ventricular function. J Am Coll Cardiol 2010, In press. This article includes a comparison of fully automated perfusion quantification for conventional and fast SPECT.

20.

Slomka PJ, Nishina H, Berman DS, et al.: Automated quantification of myocardial perfusion SPECT using simplified normal limits. J Nucl Cardiol 2005, 12:66–77.CrossRefPubMed

21.

Germano G, Kiat H, Kavanagh PB, et al.: Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 1995, 36:2138–2147.PubMed

22.

Maddahi J, Mendez R, Mahmarian JJ, et al.: Prospective multicenter evaluation of rapid, gated SPECT myocardial perfusion upright imaging. J Nucl Cardiol 2009, 16:351–357.CrossRefPubMed

23.

DePuey EG, Bommireddipalli S, Clark J, et al.: Wide beam reconstruction “quarter-time” gated myocardial perfusion SPECT functional imaging: a comparison to “full-time” ordered subset expectation maximum. J Nucl Cardiol 2009, 16:736–752.CrossRefPubMed

24.

Cahill JM, Ficaro EP, Corbett JR: 4.11: Value of same-session coronary artery calcium (CAC) scoring in the setting of stress myocardial perfusion imaging (MPI) using CT-based attenuation correction (CTAC). J Nucl Cardiol 2008, 15:12.CrossRef

25.

Koss J, Kirch D, Steele P: Fast acquisition of myocardial perfusion and LV contractile indices with multi-pinhole SPECT [abstract]. J Nucl Med 2009, 50(Suppl 2):1144.

26.

Heller GV, Bateman TM, Johnson LL, et al.: Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging. J Nucl Cardiol 2004, 11:273–281.CrossRefPubMed

27.

Iskandrian AE: Stress-only myocardial perfusion imaging: a new paradigm. J Am Coll Cardiol 2009, In press.

28.

Venero CV, Heller GV, Bateman TM, et al.: A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol 2009, 16:714–725.CrossRefPubMed

29.

Ali I, Ruddy TD, Almgrahi A, et al.: Half-time SPECT myocardial perfusion imaging with attenuation correction. J Nucl Med 2009, 50:554.CrossRefPubMed

30.

• Bateman TM, Heller GV, McGhie AI, et al.: Multicenter investigation comparing a highly efficient half-time stress-only attenuation correction approach against standard rest-stress Tc-99m SPECT imaging. J Nucl Cardiol 2009, 16:726–735. This article demonstrates the feasibility of stress-only fast MPS protocols.CrossRefPubMed

31.

Gambhir SS, Berman DS, Ziffer J, et al.: A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med 2009, 50:635.CrossRefPubMed

32.

Kacperski K, Erlandsson K, Ben-Haim S, et al.: Iterative deconvolution of simultaneous dual radionuclide projections for CdZnTe based cardiac SPECT. IEEE Nuclear Science Symposium Conference Record; 2008:5260–5263.

33.

Kiat H, Germano G, Friedman J, et al.: Comparative feasibility of separate or simultaneous rest thallium-201/stress technetium-99m-sestamibi dual-isotope myocardial perfusion SPECT. J Nucl Med 1994, 35:542.PubMed

34.

Steele PP, Kirch DL, Koss JE: Comparison of simultaneous dual-isotope multipinhole SPECT with rotational SPECT in a group of patients with coronary artery disease. J Nucl Med 2008, 49:1080.

35.

Ben-Haim S, Kacperski K, Hain S, et al.: Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera. Eur J Nucl Med Mol Imaging 2010, In press.

36.

Beller GA: Will cardiac positron emission tomography ultimately replace SPECT for myocardial perfusion imaging? J Nucl Cardiol 2009, 16:841–843.CrossRefPubMed

37.

Funk T, Kirch DL, Koss JE, et al.: A novel approach to multipinhole SPECT for myocardial perfusion imaging. J Nucl Med 2006, 47:595–602.PubMed

38.

Huang Q, Boutchko R, Reutter B, Gullberg G: Dynamic imaging with a novel dedicated cardiac SPECT system. J Nucl Med 2009, 50(Suppl 2):525P.

39.

Breault C, Roth N, Slomka P, et al.: Quantification of coronary vasodilator reserve using dynamic SPECT imaging: a feasibility study [abstract]. J Nucl Cardiol 2010, (in press).

40.

Slomka P, Kavanagh PB, Javadi M, et al.: Evaluation of a new automatic algorithm for quantification of ECG-gated 82Rb cardiac PET. J Nucl Med 2009, 50(Suppl 2):217P.

41.

Slomka PJ, Berman DS, Germano G: Applications and software techniques for integrated cardiac multimodality imaging. Exp Rev Cardiovasc Ther 2008, 6:27–41.CrossRef

42.

Gutstein A, Wolak A, Lee C, et al.: Predicting success of prospective and retrospective gating with dual-source coronary computed tomography angiography: development of selection criteria and initial experience. J Cardiovasc Comput Tomogr 2008, 2:81-90.CrossRefPubMed

43.

• Husmann L, Herzog BA, Gaemperli O, et al.: Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: comparison of prospective electrocardiogram-triggering vs. retrospective gating. Eur Heart J 2009, 30:600. Novel protocols are proposed in this article, which combine MPS and CCTA.CrossRefPubMed

44.

DePuey EG: New software methods to cope with reduced counting statistics: shorter SPECT acquisitions and many more possibilities. J Nucl Cardiol 2009, 16:335–338.CrossRefPubMed

45.

Achenbach S, Marwan M, Ropers D, et al.: Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition. Eur Heart J 2010, 31:340–346.CrossRefPubMed

46.

Santana CA, Garcia EV, Faber TL, et al.: Diagnostic performance of fusion of myocardial perfusion imaging (MPI) and computed tomography coronary angiography. J Nucl Cardiol 2009, 16:201–211.CrossRefPubMed

47.

Slomka PJ, Cheng VY, Dey D, et al.: Quantitative analysis of myocardial perfusion SPECT anatomically guided by coregistered 64-slice coronary CT angiography. J Nucl Med 2009, 50:1621–1630.CrossRefPubMed

48.

Zeng GL, Stevens AM: Multidivergent-beam stationary cardiac SPECT. Med Phys 2009, 36:2860–2869.CrossRefPubMed

49.

Dey J: Conference record for IEEE NSS-MIC. 2009, In press.

Title: New Imaging Protocols for New Single Photon Emission CT Technologies
Authors: Piotr J. Slomka
Daniel S. Berman
Guido Germano
Publication date: 01-06-2010
Publisher: Current Science Inc.
Published in: Current Cardiovascular Imaging Reports / Issue 3/2010
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-010-9021-0

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