Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Internal and Emergency Medicine
Published in: Internal and Emergency Medicine 7/2020

01-10-2020 | Eclampsia | IM - CASE RECORD

Recurrent thrombocytopenia in pregnancy: is it always an obstetric complication?

Authors: Angelo Ostuni, Giovanni Favuzzi, Cosima Battista, Angela Tullo, Filomena Cappucci, Alexander Makatsariya, Giovanni Luca Tiscia, Elvira Grandone

Published in: Internal and Emergency Medicine | Issue 7/2020

Login to get access

Excerpt

We describe the case of a Caucasian woman from Southern Italy, who delivered for the first time in September 2000 at 21 years; 4 months later she showed fever and disturbed consciousness; a blood count prescribed on this occasion demonstrated a dramatic platelet drop, that was successfully treated by means of corticosteroids and Plasma-Exchange (PEX). In April 2004 at 34th week of her second pregnancy, she was admitted to the hospital because of a severe thrombocytopenia and normocytic anemia; a cesarean section (CS) was planned, but she delivered by a vaginal birth a male weighing 2700 g. She was transfused with red blood cells (RBC) and successfully treated by corticosteroids and plasma. …
Literature
1.
Jiang Y, McIntosh JJ, Reese JA et al (2014) Pregnancy outcomes following recovery from acquired thrombotic thrombocytopenic purpura. Blood 123:1674–1680CrossRef
2.
Hassan S, Westwood JP, Ellis D et al (2015) The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry. Br J Haematol 17:830–835CrossRef
3.
Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (2017) Thrombotic thrombocytopenic purpura. Nat Rev Dis Prim 3:17020CrossRef
4.
George JN, Nester CM (2014) Syndromes of thrombotic microangiopathy. N Engl J Med 371:654–666CrossRef
5.
Grandone E, Margaglione M, Pavone G (1997) Thrombotic thrombocytopenic purpura in pregnancy: a multifaceted disease. Am J Obstet Gynecol 177:486PubMed
6.
Scully M, Cataland S, Coppo P, International Working Group for Thrombotic Thrombocytopenic Purpura et al (2017) Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Haemost 15:312–322CrossRef
7.
Kershaw G, Favaloro EJ (2012) Laboratory identification of factor inhibitors: an update. Pathology 44:293–302CrossRef
8.
Bendapudi PK, Hurwitz S, Fry A et al (2017) Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol 4:e157–e164CrossRef
9.
Tiscia GL, Ostuni A, Cascavilla N et al (2018) Validation of PLASMIC score and follow-up data in a cohort of patients with suspected microangiopathies from Southern Italy. J Thromb Thrombolysis 46:174–179CrossRef
10.
Michel M, Chanet V, Dechartres A, Morin AS, Piette JC, Cirasino L et al (2009) The spectrum of Evans syndrome in adults: new insight into the disease based on the analysis of 68 cases. Blood 114:3167–3172CrossRef
11.
Capecchi M, Artoni A, Cappellini MD, Graziadei G (2018) What is behind a relapse of thrombotic thrombocytopenic purpura? Intern Emerg Med 13:709–712CrossRef
12.
Kremer Hovinga JA, Vesely SK, Terrell DR, Lämmle B, George JN (2010) Survival and relapse in patients with thrombotic thrombocytopenic purpura. Blood 115:1500–1511CrossRef
13.
Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, collaborators of the UK TTP Registry et al (2014) Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes. Blood 124:211–219CrossRef
14.
Lam K, Martlew V, Walkinshaw S, Alfirevic Z, Howse M (2010) Successful management of recurrent pregnancy-related thrombotic thrombocytopaenia purpura in a renal transplant recipient. Nephrol Dial Transplant 25:2378–2380CrossRef
15.
Raman R, Yang S, Wu HM, Cataland SR (2011) ADAMTS13 activity and the risk of thrombotic thrombocytopenic purpura relapse in pregnancy. Br J Haematol 153:277–279CrossRef
16.
Martin JN Jr, Bailey AP, Rehberg JF, Owens MT, Keiser SD, May WL (2008) Thrombotic thrombocytopenic purpura in 166 pregnancies: 1955–2006. Am J Obstet Gynecol 199:98–104CrossRef
17.
18.
Pham-Huy A, Sadarangani M, Huang V, Ostensen M, Castillo E, Troster SM et al (2019) From mother to baby: antenatal exposure to monoclonal antibody biologics. Expert Rev Clin Immunol 15:221–229CrossRef
19.
Akolekar R, Syngelaki A, Poon L, Wright D, Nicolaides KH (2013) Competing risks model in early screening for pre-eclampsia by biophysical and biochemical markers. Fetal Diagn Ther 33:8–15CrossRef
Metadata
Title
Recurrent thrombocytopenia in pregnancy: is it always an obstetric complication?
Authors
Angelo Ostuni
Giovanni Favuzzi
Cosima Battista
Angela Tullo
Filomena Cappucci
Alexander Makatsariya
Giovanni Luca Tiscia
Elvira Grandone
Publication date
01-10-2020
Publisher
Springer International Publishing
Published in
Internal and Emergency Medicine / Issue 7/2020
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-019-02136-x

Other articles of this Issue 7/2020

Internal and Emergency Medicine 7/2020 Go to the issue

IM - ORIGINAL

Management of antithrombotic therapy in gray areas of venous thromboembolism: a Delphi consensus panel

CE-Research Letter to the Editor

Risk factors of in-hospital death in patients with acute ST elevation myocardial infarction

Guidelines and Position papers

Approaching acute pain in emergency settings: European Society for Emergency Medicine (EUSEM) guidelines—part 1: assessment

IM - COMMENTARY

How valuable is cardiopulmonary exercise testing in patients with severe obesity undergoing bariatric surgery?

EM - ORIGINAL

The assessment of dermatological emergencies in the emergency department via telemedicine is safe: a prospective pilot study

IM - REVIEW

Antithrombotic treatment of asymptomatic carotid atherosclerosis: a medical dilemma
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits