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Published in: Obesity Surgery 7/2017

01-07-2017 | Original Contributions

Evaluation of Vitamin and Trace Element Requirements after Sleeve Gastrectomy at Long Term

Authors: Silvia Pellitero, Eva Martínez, Rocío Puig, Alba Leis, Roxanna Zavala, María Luisa Granada, Cruz Pastor, Pau Moreno, Jordi Tarascó, Manel Puig-Domingo

Published in: Obesity Surgery | Issue 7/2017

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Abstract

Background

Nutritional deficiencies are common after bariatric surgery, but data are scarce after sleeve gastrectomy (SG) at long term.

Methods

We performed a prospective nutritional status evaluation before and at 2 and 5 years after SG in morbid obese patients receiving mulvitamin and mineral supplementation at a Spanish university hospital. One hundred seventy-six patients (49.3 ± 9.1 years and 46.7 ± 7.4 kg/m2) were evaluated; 51 of them were followed during 5 years. Anthropometric, compliance supplementation intake, and micronutrient evaluation were performed.

Results

Baseline concentrations were below normal values for 25(OH) vitamin D (73%), folic acid (16.5%), cobalamin (6.9%), pyridoxine (12%), thiamine (3.4%), and copper (0.5%). Anemia was found in 23%. In 49% of the subjects, at least one micronutrient deficiency was found at 2 years after SG. Vitamin D deficiency persisted at 2 and 5 years higher than 30% of patients. Frequencies of deficiencies for folic acid, B12, B6, and B1 vitamins decreased significantly after 2 years with normalization at 5 years. Copper deficiency increased between 1 and 2 years and it persisted at 5 years after SG. Vitamin supplementation compliance decreased progressively from the first year after surgery (94.8 to 81% at 2 years and to 53% 5 years after surgery).

Conclusions

Vitamin D deficiency is the most prevalent long-term nutritional deficiency after SG. About half of patients show some micronutrient deficiency at medium long term, despite supplementation. A proactive follow-up is required to ensure a personalized and adequate supplementation in all surgically treated obese patients including those in which SG has been performed.
Literature
1.
go back to reference Gutiérrez-Fisac JL, Guallar-Castillón P, León-Muñoz LM, et al. Prevalence of general and abdominal obesity in the adult population of Spain, 2008-2010: the ENRICA study. Obes Rev. 2012;13(4):388–92.CrossRefPubMed Gutiérrez-Fisac JL, Guallar-Castillón P, León-Muñoz LM, et al. Prevalence of general and abdominal obesity in the adult population of Spain, 2008-2010: the ENRICA study. Obes Rev. 2012;13(4):388–92.CrossRefPubMed
2.
go back to reference Padwal R, Klarenbach S, Wiebe N, et al. Bariatric surgery: a systematic review and network meta-analysis of randomized trials. Obes Rev. 2011;12(8):602–21.CrossRefPubMed Padwal R, Klarenbach S, Wiebe N, et al. Bariatric surgery: a systematic review and network meta-analysis of randomized trials. Obes Rev. 2011;12(8):602–21.CrossRefPubMed
3.
go back to reference Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Endocrine society. evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.CrossRefPubMed Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Endocrine society. evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.CrossRefPubMed
4.
go back to reference Moizé V, Deulofeu R, Torres F, et al. Nutritional intake and prevalence of nutritional deficiencies prior to surgery in a Spanish morbidly obese population. Obes Surg. 2011;21(9):1382–8.CrossRefPubMed Moizé V, Deulofeu R, Torres F, et al. Nutritional intake and prevalence of nutritional deficiencies prior to surgery in a Spanish morbidly obese population. Obes Surg. 2011;21(9):1382–8.CrossRefPubMed
5.
go back to reference Sánchez A, Rojas P, Basfi-Fer K, et al. Micronutrient deficiencies in morbidly obese women prior to bariatric surgery. Obes Surg. 2016;26(2):361–8.CrossRefPubMed Sánchez A, Rojas P, Basfi-Fer K, et al. Micronutrient deficiencies in morbidly obese women prior to bariatric surgery. Obes Surg. 2016;26(2):361–8.CrossRefPubMed
6.
go back to reference Damms-Machado A, Friedrich A, Kramer KM, et al. Pre- and postoperative nutritional deficiencies in obese patients undergoing laparoscopic sleeve gastrectomy. Obes Surg. 2012;22(6):881–9.CrossRefPubMed Damms-Machado A, Friedrich A, Kramer KM, et al. Pre- and postoperative nutritional deficiencies in obese patients undergoing laparoscopic sleeve gastrectomy. Obes Surg. 2012;22(6):881–9.CrossRefPubMed
7.
go back to reference Almogy G, Crookes PF, Anthone GJ. Longitudinal gastrectomy as a treatment for the high-risk super-obese patient. Obes Surg. 2004;14(4):492–7.CrossRefPubMed Almogy G, Crookes PF, Anthone GJ. Longitudinal gastrectomy as a treatment for the high-risk super-obese patient. Obes Surg. 2004;14(4):492–7.CrossRefPubMed
8.
go back to reference Sammour T, Hill AG, Singh P, et al. Laparoscopic sleeve gastrectomy as a single-stage bariatric procedure. Obes Surg. 2010;20(3):271–5.CrossRefPubMed Sammour T, Hill AG, Singh P, et al. Laparoscopic sleeve gastrectomy as a single-stage bariatric procedure. Obes Surg. 2010;20(3):271–5.CrossRefPubMed
9.
go back to reference Casella G, Soricelli E, Giannotti D, et al. Long-term results after laparoscopic sleeve gastrectomy in a large monocentric series. Surg Obes Relat Dis. 2016;12(4):757–62.CrossRefPubMed Casella G, Soricelli E, Giannotti D, et al. Long-term results after laparoscopic sleeve gastrectomy in a large monocentric series. Surg Obes Relat Dis. 2016;12(4):757–62.CrossRefPubMed
10.
go back to reference D'Hondt M, Vanneste S, Pottel H, et al. Laparoscopic sleeve gastrectomy as a single-stage procedure for the treatment of morbid obesity and the resulting quality of life, resolution of comorbidities, food tolerance, and 6-year weight loss. Surg Endosc. 2011;25(8):2498–504.CrossRefPubMed D'Hondt M, Vanneste S, Pottel H, et al. Laparoscopic sleeve gastrectomy as a single-stage procedure for the treatment of morbid obesity and the resulting quality of life, resolution of comorbidities, food tolerance, and 6-year weight loss. Surg Endosc. 2011;25(8):2498–504.CrossRefPubMed
11.
go back to reference Coupaye M, Rivière P, Breuil MC, et al. Comparison of nutritional status during the first year after sleeve gastrectomy and roux-en-Y gastric bypass. Obes Surg. 2014;24(2):276–83.CrossRefPubMed Coupaye M, Rivière P, Breuil MC, et al. Comparison of nutritional status during the first year after sleeve gastrectomy and roux-en-Y gastric bypass. Obes Surg. 2014;24(2):276–83.CrossRefPubMed
12.
go back to reference Leyba JL, Llopis SN, Aulestia SN. Laparoscopic roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for the treatment of morbid obesity. A prospective study with 5 years of follow-up. Obes Surg. 2014;24(12):2094–8.CrossRefPubMed Leyba JL, Llopis SN, Aulestia SN. Laparoscopic roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy for the treatment of morbid obesity. A prospective study with 5 years of follow-up. Obes Surg. 2014;24(12):2094–8.CrossRefPubMed
13.
go back to reference Aarts EO, Janssen IM, Berends FJ. The gastric sleeve: losing weight as fast as micronutrients? Obes Surg. 2011;21(2):207–11.CrossRefPubMed Aarts EO, Janssen IM, Berends FJ. The gastric sleeve: losing weight as fast as micronutrients? Obes Surg. 2011;21(2):207–11.CrossRefPubMed
14.
go back to reference Gehrer S, Kern B, Peters T, et al. Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (SG) than after laparoscopic roux-Y-gastric bypass (LRYGB)—a prospective study. Obes Surg. 2010;20(4):447–53.CrossRefPubMed Gehrer S, Kern B, Peters T, et al. Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (SG) than after laparoscopic roux-Y-gastric bypass (LRYGB)—a prospective study. Obes Surg. 2010;20(4):447–53.CrossRefPubMed
15.
go back to reference Belfiore A, Cataldi M, Minichini L, et al. Short-term changes in body composition and response to micronutrient supplementation after laparoscopic sleeve gastrectomy. Obes Surg. 2015;25(12):2344–51.CrossRefPubMed Belfiore A, Cataldi M, Minichini L, et al. Short-term changes in body composition and response to micronutrient supplementation after laparoscopic sleeve gastrectomy. Obes Surg. 2015;25(12):2344–51.CrossRefPubMed
16.
go back to reference Alvarez V, Cuevas A, Olivos C, et al. Micronutrient deficiencies one year after sleeve gastrectomy. Nutr Hosp. 2014;29(1):73–9.PubMed Alvarez V, Cuevas A, Olivos C, et al. Micronutrient deficiencies one year after sleeve gastrectomy. Nutr Hosp. 2014;29(1):73–9.PubMed
17.
go back to reference Shankar P, Boylan M, Sriram K. Micronutrient deficiencies after bariatric surgery. Nutrition. 2010;26(11–12):1031–7.CrossRefPubMed Shankar P, Boylan M, Sriram K. Micronutrient deficiencies after bariatric surgery. Nutrition. 2010;26(11–12):1031–7.CrossRefPubMed
18.
go back to reference Pech N, Meyer F, Lippert H, et al. Complications, reoperations, and nutrient deficiencies two years after sleeve gastrectomy. J Obes. 2012;828737 Pech N, Meyer F, Lippert H, et al. Complications, reoperations, and nutrient deficiencies two years after sleeve gastrectomy. J Obes. 2012;828737
19.
go back to reference Saif T, Strain GW, Dakin G, et al. Evaluation of nutrient status after laparoscopic sleeve gastrectomy 1, 3, and 5 years after surgery. Surg Obes Relat Dis. 2012;8(5):542–7.CrossRefPubMed Saif T, Strain GW, Dakin G, et al. Evaluation of nutrient status after laparoscopic sleeve gastrectomy 1, 3, and 5 years after surgery. Surg Obes Relat Dis. 2012;8(5):542–7.CrossRefPubMed
20.
go back to reference Moizé V, Andreu A, Flores L, et al. Long-term dietary intake and nutritional deficiencies following sleeve gastrectomy or roux-en-Y gastric bypass in a Mediterranean population. J Acad Nutr Diet. 2013;113(3):400–10.CrossRefPubMed Moizé V, Andreu A, Flores L, et al. Long-term dietary intake and nutritional deficiencies following sleeve gastrectomy or roux-en-Y gastric bypass in a Mediterranean population. J Acad Nutr Diet. 2013;113(3):400–10.CrossRefPubMed
21.
go back to reference Alexandrou A, Armeni E, Kouskouni E. Cross-sectional long-term micronutrient deficiencies after sleeve gastrectomy versus roux-en-Y gastric bypass: a pilot study. Surg Obes Relat Dis. 2014;10(2):262–8.CrossRefPubMed Alexandrou A, Armeni E, Kouskouni E. Cross-sectional long-term micronutrient deficiencies after sleeve gastrectomy versus roux-en-Y gastric bypass: a pilot study. Surg Obes Relat Dis. 2014;10(2):262–8.CrossRefPubMed
22.
go back to reference Rubio MA, Monereo S, Lecube A, et al. Joint position statement of the SEEN-SECO-SEEDO-SED societies on metabolic surgery for type 2 diabetes mellitus. Endocrinol Nutr. 2013;60(10):547–8.CrossRefPubMed Rubio MA, Monereo S, Lecube A, et al. Joint position statement of the SEEN-SECO-SEEDO-SED societies on metabolic surgery for type 2 diabetes mellitus. Endocrinol Nutr. 2013;60(10):547–8.CrossRefPubMed
24.
go back to reference Mechanick JI, Youdim A, Jones DB, et al. American Association of Clinical Endocrinologists; Obesity Society; American Society for Metabolic & Bariatric Surgery. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;(Suppl 1):S1–27. Mechanick JI, Youdim A, Jones DB, et al. American Association of Clinical Endocrinologists; Obesity Society; American Society for Metabolic & Bariatric Surgery. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;(Suppl 1):S1–27.
25.
go back to reference Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4):1033–44.CrossRefPubMed Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4):1033–44.CrossRefPubMed
26.
go back to reference Serra-Planas E, Aguilera E, Granada ML, et al. High prevalence of vitamin D deficiency and lack of association with subclinical atherosclerosis in asymptomatic patients with type 1 diabetes mellitus from a Mediterranean area. Acta Diabetol. 2015;52(4):773–9.CrossRefPubMed Serra-Planas E, Aguilera E, Granada ML, et al. High prevalence of vitamin D deficiency and lack of association with subclinical atherosclerosis in asymptomatic patients with type 1 diabetes mellitus from a Mediterranean area. Acta Diabetol. 2015;52(4):773–9.CrossRefPubMed
27.
go back to reference Van Rutte PW, Aarts EO, Smulders JF, et al. Nutrient deficiencies before and after sleeve gastrectomy. Obes Surg. 2014;24(10):1639–46.CrossRefPubMed Van Rutte PW, Aarts EO, Smulders JF, et al. Nutrient deficiencies before and after sleeve gastrectomy. Obes Surg. 2014;24(10):1639–46.CrossRefPubMed
28.
go back to reference Kaidar-Person O, Person B, Szomstein S, et al. Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part B:minerals Obes Surg. 2008;18(8):1028–34.PubMed Kaidar-Person O, Person B, Szomstein S, et al. Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part B:minerals Obes Surg. 2008;18(8):1028–34.PubMed
29.
go back to reference Malinowski SS. Nutritional and metabolic complications of bariatric surgery. Am J Med Sci. 2006;331(4):219–25.CrossRefPubMed Malinowski SS. Nutritional and metabolic complications of bariatric surgery. Am J Med Sci. 2006;331(4):219–25.CrossRefPubMed
30.
go back to reference Lanzarini E, Nogués X, Goday A, et al. High-dose vitamin D supplementation is necessary after bariatric surgery: a prospective 2-year follow-up study. Obes Surg. 2015;25(9):1633–8.CrossRefPubMed Lanzarini E, Nogués X, Goday A, et al. High-dose vitamin D supplementation is necessary after bariatric surgery: a prospective 2-year follow-up study. Obes Surg. 2015;25(9):1633–8.CrossRefPubMed
31.
go back to reference Ruiz-Tovar J, Oller I, Tomas A, et al. Mid-term effects of sleeve gastrectomy on calcium metabolism parameters, vitamin D and parathormone (PTH) in morbid obese women. Obes Surg. 2012;22(5):797–801l.CrossRefPubMed Ruiz-Tovar J, Oller I, Tomas A, et al. Mid-term effects of sleeve gastrectomy on calcium metabolism parameters, vitamin D and parathormone (PTH) in morbid obese women. Obes Surg. 2012;22(5):797–801l.CrossRefPubMed
32.
go back to reference Boyce SG, Goriparthi R, Clark J, et al. Can composite nutritional supplement based on the current guidelines prevent vitamin and mineral deficiency after weight loss surgery? Obes Surg. 2016;26(5):966–71.CrossRefPubMed Boyce SG, Goriparthi R, Clark J, et al. Can composite nutritional supplement based on the current guidelines prevent vitamin and mineral deficiency after weight loss surgery? Obes Surg. 2016;26(5):966–71.CrossRefPubMed
33.
go back to reference Muschitz C, Kocijan R, Haschka J, et al. The impact of vitamin D, calcium, protein supplementation, and physical exercise on bone metabolism after bariatric surgery: the BABS study. J Bone Miner Res. 2016;31(3):672–82.CrossRefPubMed Muschitz C, Kocijan R, Haschka J, et al. The impact of vitamin D, calcium, protein supplementation, and physical exercise on bone metabolism after bariatric surgery: the BABS study. J Bone Miner Res. 2016;31(3):672–82.CrossRefPubMed
34.
go back to reference Flores L, Moizé V, Ortega E, et al. Prospective study of individualized or high fixed doses of vitamin D supplementation after bariatric surgery. Obes Surg. 2015;25(3):470–6.CrossRefPubMed Flores L, Moizé V, Ortega E, et al. Prospective study of individualized or high fixed doses of vitamin D supplementation after bariatric surgery. Obes Surg. 2015;25(3):470–6.CrossRefPubMed
35.
go back to reference Moore CE, Sherman V. Vitamin D supplementation efficacy: sleeve gastrectomy versus gastric bypass surgery. Obes Surg. 2014;24(12):2055–60.CrossRefPubMed Moore CE, Sherman V. Vitamin D supplementation efficacy: sleeve gastrectomy versus gastric bypass surgery. Obes Surg. 2014;24(12):2055–60.CrossRefPubMed
36.
go back to reference Fried M, Yumuk V, Oppert JM, et al. International Federation for Surgery of obesity and metabolic disorders-European chapter (IFSO-EC); European Association for the Study of Obesity (EASO); European Association for the Study of obesity obesity management task force (EASO OMTF). Interdisciplinary European guidelines on metabolic and bariatric surgery. Obes Surg. 2014;24(1):42–55.CrossRefPubMed Fried M, Yumuk V, Oppert JM, et al. International Federation for Surgery of obesity and metabolic disorders-European chapter (IFSO-EC); European Association for the Study of Obesity (EASO); European Association for the Study of obesity obesity management task force (EASO OMTF). Interdisciplinary European guidelines on metabolic and bariatric surgery. Obes Surg. 2014;24(1):42–55.CrossRefPubMed
37.
38.
go back to reference Goodman JC. Neurological complications of bariatric surgery. Curr Neurol Neurosci Rep. 2015;15(12):79.CrossRefPubMed Goodman JC. Neurological complications of bariatric surgery. Curr Neurol Neurosci Rep. 2015;15(12):79.CrossRefPubMed
39.
go back to reference Kröll D, Laimer M, Borbély YM, et al. Wernicke encephalopathy: a future problem even after sleeve gastrectomy? A Systematic Literature Review Obes Surg. 2016;26(1):205–12.PubMed Kröll D, Laimer M, Borbély YM, et al. Wernicke encephalopathy: a future problem even after sleeve gastrectomy? A Systematic Literature Review Obes Surg. 2016;26(1):205–12.PubMed
40.
go back to reference Saab R, El Khoury M, Farhat S. Wernicke's encephalopathy three weeks after sleeve gastrectomy. Surg Obes Relat Dis. 2014;10(5):992–4.CrossRefPubMed Saab R, El Khoury M, Farhat S. Wernicke's encephalopathy three weeks after sleeve gastrectomy. Surg Obes Relat Dis. 2014;10(5):992–4.CrossRefPubMed
41.
go back to reference Papamargaritis D, Aasheim ET, Sampson B, et al. Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation. J Trace Elem Med Biol. 2015;31:167–72.CrossRefPubMed Papamargaritis D, Aasheim ET, Sampson B, et al. Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation. J Trace Elem Med Biol. 2015;31:167–72.CrossRefPubMed
42.
go back to reference Dunstan MJ, Molena EJ, Ratnasingham K, et al. Variations in oral vitamin and mineral supplementation following bariatric gastric bypass surgery: a national survey. Obes Surg. 2015;25(4):648–55.CrossRefPubMed Dunstan MJ, Molena EJ, Ratnasingham K, et al. Variations in oral vitamin and mineral supplementation following bariatric gastric bypass surgery: a national survey. Obes Surg. 2015;25(4):648–55.CrossRefPubMed
Metadata
Title
Evaluation of Vitamin and Trace Element Requirements after Sleeve Gastrectomy at Long Term
Authors
Silvia Pellitero
Eva Martínez
Rocío Puig
Alba Leis
Roxanna Zavala
María Luisa Granada
Cruz Pastor
Pau Moreno
Jordi Tarascó
Manel Puig-Domingo
Publication date
01-07-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 7/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-017-2557-1

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