Skip to main content
Top
Published in: Obesity Surgery 4/2010

01-04-2010 | Clinical Report

Fewer Nutrient Deficiencies After Laparoscopic Sleeve Gastrectomy (LSG) than After Laparoscopic Roux-Y-Gastric Bypass (LRYGB)—a Prospective Study

Authors: Simone Gehrer, Beatrice Kern, Thomas Peters, Caroline Christoffel-Courtin, Ralph Peterli

Published in: Obesity Surgery | Issue 4/2010

Login to get access

Abstract

Background

Deficiencies in micronutrients after bariatric operations are frequent, despite routine supplementation. Main outcome measures were pre- and postoperative frequency of nutrient deficiencies and success rate of their treatment.

Methods

Between 5/2004 and 12/2006, 136 patients (m:f = 0:4) with an average body mass index of 45 (35–58) kg/m2 and age of 53 (21–66) years were prospectively analysed. Laparoscopic Roux-Y-gastric bypass (LRYGB) was performed in 86 patients and laparoscopic sleeve gastrectomy (LSG) was performed in 50 patients. The patients were examined before surgery as well as 3, 6, 12, 24, 30, and 36 months postoperatively using a standard protocol including laboratory tests. The mean follow-up time was 24.4 (12–40) months; the follow-up rate was 100%.

Results

Prior to surgery, 57% of the patients had at least one deficiency, 23% of whom had vitamin D3 deficiency. Frequent postoperative deficiencies after LSG were zinc, vitamin D3, folic acid, iron, and vitamin B12; after LRYGB, vitamin B12, vitamin D3, zinc, and secondary hyperparathyroidism. No vitamin B1 or B6 deficiencies were found. Calcium levels were normal in all patients. Treatment of the deficiencies was mostly successful.

Conclusion

Preoperatively, 57% of morbidly obese patients already had a deficiency. Postoperatively, significantly more vitamin B12 and vitamin D deficiencies and hyperparathyroidism were found in patients who had undergone LRYGB. After LSG, folate deficiency was more frequent (but not significantly so). Calcium levels were normal in all patients; therefore, parathyroid hormone and vitamin D3 levels are more sensitive markers for early detection of disorders of calcium metabolism. Iron deficiency anaemia is most efficiently treated by IV therapy.
Literature
1.
go back to reference Sjostrom L et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.CrossRefPubMed Sjostrom L et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.CrossRefPubMed
2.
go back to reference O’Brien PE, Dixon JB. Laparoscopic adjustable gastric banding in the treatment of morbid obesity. Arch Surg. 2003;138(4):376–82.CrossRefPubMed O’Brien PE, Dixon JB. Laparoscopic adjustable gastric banding in the treatment of morbid obesity. Arch Surg. 2003;138(4):376–82.CrossRefPubMed
3.
go back to reference Buchwald H et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.CrossRefPubMed Buchwald H et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.CrossRefPubMed
4.
5.
go back to reference Maggard MA et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142(7):547–59.PubMed Maggard MA et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142(7):547–59.PubMed
6.
go back to reference Solomon CG, Dluhy RG. Bariatric surgery—quick fix or long-term solution? N Engl J Med. 2004;351(26):2751–3.CrossRefPubMed Solomon CG, Dluhy RG. Bariatric surgery—quick fix or long-term solution? N Engl J Med. 2004;351(26):2751–3.CrossRefPubMed
8.
go back to reference Davies DJ, Baxter JM, Baxter JN. Nutritional deficiencies after bariatric surgery. Obes Surg. 2007;17(9):1150–8.CrossRefPubMed Davies DJ, Baxter JM, Baxter JN. Nutritional deficiencies after bariatric surgery. Obes Surg. 2007;17(9):1150–8.CrossRefPubMed
9.
go back to reference Chapman AE et al. Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review. Surgery. 2004;135(3):326–51.CrossRefPubMed Chapman AE et al. Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review. Surgery. 2004;135(3):326–51.CrossRefPubMed
10.
go back to reference Giusti V et al. Effects of laparoscopic gastric banding on body composition, metabolic profile and nutritional status of obese women: 12-months follow-up. Obes Surg. 2004;14(2):239–45.CrossRefPubMed Giusti V et al. Effects of laparoscopic gastric banding on body composition, metabolic profile and nutritional status of obese women: 12-months follow-up. Obes Surg. 2004;14(2):239–45.CrossRefPubMed
11.
go back to reference Nguyen NT et al. Staged laparoscopic Roux-en-Y: a novel two-stage bariatric operation as an alternative in the super-obese with massively enlarged liver. Obes Surg. 2005;15(7):1077–81.CrossRefPubMed Nguyen NT et al. Staged laparoscopic Roux-en-Y: a novel two-stage bariatric operation as an alternative in the super-obese with massively enlarged liver. Obes Surg. 2005;15(7):1077–81.CrossRefPubMed
12.
go back to reference Cottam D et al. Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc. 2006;20(6):859–63.CrossRefPubMed Cottam D et al. Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc. 2006;20(6):859–63.CrossRefPubMed
13.
go back to reference Regan JP et al. Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient. Obes Surg. 2003;13(6):861–4.CrossRefPubMed Regan JP et al. Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient. Obes Surg. 2003;13(6):861–4.CrossRefPubMed
14.
go back to reference Melissas J et al. Sleeve gastrectomy—a “food limiting” operation. Obes Surg. 2008;18(10):1251–6.CrossRefPubMed Melissas J et al. Sleeve gastrectomy—a “food limiting” operation. Obes Surg. 2008;18(10):1251–6.CrossRefPubMed
15.
go back to reference Roa PE et al. Laparoscopic sleeve gastrectomy as treatment for morbid obesity: technique and short-term outcome. Obes Surg. 2006;16(10):1323–6.CrossRefPubMed Roa PE et al. Laparoscopic sleeve gastrectomy as treatment for morbid obesity: technique and short-term outcome. Obes Surg. 2006;16(10):1323–6.CrossRefPubMed
16.
go back to reference Karamanakos SN et al. Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study. Ann Surg. 2008;247(3):401–7.CrossRefPubMed Karamanakos SN et al. Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study. Ann Surg. 2008;247(3):401–7.CrossRefPubMed
17.
go back to reference Santoro S et al. Enterohormonal changes after digestive adaptation: five-year results of a surgical proposal to treat obesity and associated diseases. Obes Surg. 2008;18(1):17–26.CrossRefPubMed Santoro S et al. Enterohormonal changes after digestive adaptation: five-year results of a surgical proposal to treat obesity and associated diseases. Obes Surg. 2008;18(1):17–26.CrossRefPubMed
18.
go back to reference Langer FB et al. Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg. 2005;15(7):1024–9.CrossRefPubMed Langer FB et al. Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg. 2005;15(7):1024–9.CrossRefPubMed
19.
go back to reference Peterli R et al. Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial. Annals of Surgery, 2009. accepted for publication. Peterli R et al. Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial. Annals of Surgery, 2009. accepted for publication.
20.
go back to reference Woelnerhanssen BK et al. Predictors of outcome in treatment of morbid obesity by laparoscopic adjustable gastric banding: results of a prospective study of 380 patients. Surg Obes Relat Dis. 2008;4(4):500–6.CrossRef Woelnerhanssen BK et al. Predictors of outcome in treatment of morbid obesity by laparoscopic adjustable gastric banding: results of a prospective study of 380 patients. Surg Obes Relat Dis. 2008;4(4):500–6.CrossRef
21.
go back to reference Peterli R et al. Prospective study of a two-stage operative concept in the treatment of morbid obesity: primary lap-band followed if needed by sleeve gastrectomy with duodenal switch. Obes Surg. 2007;17(3):334–40.CrossRefPubMed Peterli R et al. Prospective study of a two-stage operative concept in the treatment of morbid obesity: primary lap-band followed if needed by sleeve gastrectomy with duodenal switch. Obes Surg. 2007;17(3):334–40.CrossRefPubMed
22.
go back to reference Oria HE, Moorehead MK. Bariatric analysis and reporting outcome system (BAROS). Obes Surg. 1998;8(5):487–99.CrossRefPubMed Oria HE, Moorehead MK. Bariatric analysis and reporting outcome system (BAROS). Obes Surg. 1998;8(5):487–99.CrossRefPubMed
23.
go back to reference Vargas-Ruiz AG, Hernandez-Rivera G, Herrera MF. Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2008;18(3):288–93.CrossRefPubMed Vargas-Ruiz AG, Hernandez-Rivera G, Herrera MF. Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2008;18(3):288–93.CrossRefPubMed
24.
go back to reference Malinowski SS. Nutritional and metabolic complications of bariatric surgery. Am J Med Sci. 2006;331(4):219–25.CrossRefPubMed Malinowski SS. Nutritional and metabolic complications of bariatric surgery. Am J Med Sci. 2006;331(4):219–25.CrossRefPubMed
25.
go back to reference Fujioka K. Follow-up of nutritional and metabolic problems after bariatric surgery. Diabetes Care. 2005;28(2):481–4.CrossRefPubMed Fujioka K. Follow-up of nutritional and metabolic problems after bariatric surgery. Diabetes Care. 2005;28(2):481–4.CrossRefPubMed
26.
go back to reference Halverson JD. Micronutrient deficiencies after gastric bypass for morbid obesity. Am Surg. 1986;52(11):594–8.PubMed Halverson JD. Micronutrient deficiencies after gastric bypass for morbid obesity. Am Surg. 1986;52(11):594–8.PubMed
27.
go back to reference Brolin RE et al. Are vitamin B12 and folate deficiency clinically important after Roux-en-Y gastric bypass? J Gastrointest Surg. 1998;2(5):436–42.CrossRefPubMed Brolin RE et al. Are vitamin B12 and folate deficiency clinically important after Roux-en-Y gastric bypass? J Gastrointest Surg. 1998;2(5):436–42.CrossRefPubMed
28.
go back to reference Brolin RE, Leung M. Survey of vitamin and mineral supplementation after gastric bypass and biliopancreatic diversion for morbid obesity. Obes Surg. 1999;9(2):150–4.CrossRefPubMed Brolin RE, Leung M. Survey of vitamin and mineral supplementation after gastric bypass and biliopancreatic diversion for morbid obesity. Obes Surg. 1999;9(2):150–4.CrossRefPubMed
29.
go back to reference Johnson JM et al. Effects of gastric bypass procedures on bone mineral density, calcium, parathyroid hormone, and vitamin D. J Gastrointest Surg. 2005;9(8):1106–10. discussion 1110–1.CrossRefPubMed Johnson JM et al. Effects of gastric bypass procedures on bone mineral density, calcium, parathyroid hormone, and vitamin D. J Gastrointest Surg. 2005;9(8):1106–10. discussion 1110–1.CrossRefPubMed
30.
go back to reference Johnson JM et al. The long-term effects of gastric bypass on vitamin D metabolism. Ann Surg. 2006;243(5):701–4. discussion 704-5.CrossRefPubMed Johnson JM et al. The long-term effects of gastric bypass on vitamin D metabolism. Ann Surg. 2006;243(5):701–4. discussion 704-5.CrossRefPubMed
31.
go back to reference Kendrick J et al. 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis, 2008. Kendrick J et al. 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis, 2008.
32.
go back to reference Ritz P et al. (2008) Gastric Bypass is not associated with protein malnutrition in morbidly obese patients. Obes Surg. 2009 Jul;19(7):840–4. Epub 2008 Aug 12. Ritz P et al. (2008) Gastric Bypass is not associated with protein malnutrition in morbidly obese patients. Obes Surg. 2009 Jul;19(7):840–4. Epub 2008 Aug 12.
33.
go back to reference Ybarra J et al. Unchanged hypovitaminosis D and secondary hyperparathyroidism in morbid obesity after bariatric surgery. Obes Surg. 2005;15(3):330–5.CrossRefPubMed Ybarra J et al. Unchanged hypovitaminosis D and secondary hyperparathyroidism in morbid obesity after bariatric surgery. Obes Surg. 2005;15(3):330–5.CrossRefPubMed
34.
go back to reference Carlin AM et al. Effect of gastric bypass surgery on vitamin D nutritional status. Surg Obes Relat Dis. 2006;2(6):638–42.CrossRefPubMed Carlin AM et al. Effect of gastric bypass surgery on vitamin D nutritional status. Surg Obes Relat Dis. 2006;2(6):638–42.CrossRefPubMed
35.
go back to reference Sanchez-Hernandez J et al. Effects of bariatric surgery on vitamin D status and secondary hyperparathyroidism: a prospective study. Obes Surg. 2005;15(10):1389–95.CrossRefPubMed Sanchez-Hernandez J et al. Effects of bariatric surgery on vitamin D status and secondary hyperparathyroidism: a prospective study. Obes Surg. 2005;15(10):1389–95.CrossRefPubMed
36.
go back to reference Flancbaum L et al. Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesity. J Gastrointest Surg. 2006;10(7):1033–7.CrossRefPubMed Flancbaum L et al. Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesity. J Gastrointest Surg. 2006;10(7):1033–7.CrossRefPubMed
37.
go back to reference Carlin AM et al. Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery. Surg Obes Relat Dis. 2006;2(2):98–103. discussion 104.CrossRefPubMed Carlin AM et al. Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery. Surg Obes Relat Dis. 2006;2(2):98–103. discussion 104.CrossRefPubMed
38.
go back to reference Pires LV et al. The effect of Roux-en-Y gastric bypass on zinc nutritional status. Obes Surg. 2007;17(5):617–21.CrossRefPubMed Pires LV et al. The effect of Roux-en-Y gastric bypass on zinc nutritional status. Obes Surg. 2007;17(5):617–21.CrossRefPubMed
39.
go back to reference Di Martino G et al. Relationship between zinc and obesity. J Med. 1993;24(2–3):177–83.PubMed Di Martino G et al. Relationship between zinc and obesity. J Med. 1993;24(2–3):177–83.PubMed
40.
go back to reference Silvestre V et al. Morbid obesity and gastric bypass surgery: biochemical profile. Obes Surg. 2004;14(9):1227–32.CrossRefPubMed Silvestre V et al. Morbid obesity and gastric bypass surgery: biochemical profile. Obes Surg. 2004;14(9):1227–32.CrossRefPubMed
41.
go back to reference Alvarez-Leite JI. Nutrient deficiencies secondary to bariatric surgery. Curr Opin Clin Nutr Metab Care. 2004;7(5):569–75.CrossRefPubMed Alvarez-Leite JI. Nutrient deficiencies secondary to bariatric surgery. Curr Opin Clin Nutr Metab Care. 2004;7(5):569–75.CrossRefPubMed
42.
go back to reference Parkes E. Nutritional management of patients after bariatric surgery. Am J Med Sci. 2006;331(4):207–13.CrossRefPubMed Parkes E. Nutritional management of patients after bariatric surgery. Am J Med Sci. 2006;331(4):207–13.CrossRefPubMed
43.
go back to reference Loh Y et al. Acute Wernicke’s encephalopathy following bariatric surgery: clinical course and MRI correlation. Obes Surg. 2004;14(1):129–32.CrossRefPubMed Loh Y et al. Acute Wernicke’s encephalopathy following bariatric surgery: clinical course and MRI correlation. Obes Surg. 2004;14(1):129–32.CrossRefPubMed
44.
go back to reference Baierlein SA et al. Abdominal actinomycosis: a rare complication after laparoscopic gastric bypass. Obes Surg. 2007;17(8):1123–6.CrossRefPubMed Baierlein SA et al. Abdominal actinomycosis: a rare complication after laparoscopic gastric bypass. Obes Surg. 2007;17(8):1123–6.CrossRefPubMed
Metadata
Title
Fewer Nutrient Deficiencies After Laparoscopic Sleeve Gastrectomy (LSG) than After Laparoscopic Roux-Y-Gastric Bypass (LRYGB)—a Prospective Study
Authors
Simone Gehrer
Beatrice Kern
Thomas Peters
Caroline Christoffel-Courtin
Ralph Peterli
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 4/2010
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-009-0068-4

Other articles of this Issue 4/2010

Obesity Surgery 4/2010 Go to the issue