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01-04-2011 | Original Article

Intestinal Cancer Risk in Crohn’s Disease: A Meta-Analysis

Authors: Mike Georg Laukoetter, Rudolf Mennigen, C. Mareike Hannig, Nani Osada, Emile Rijcken, Thorsten Vowinkel, Christian F. Krieglstein, Norbert Senninger, Christoph Anthoni, Matthias Bruewer

Published in: Journal of Gastrointestinal Surgery | Issue 4/2011

Abstract

Aim of the study

To clarify the intestinal cancer risk in Crohn’s disease (CD).

Methods

20 clinical studies (1965–2008) with a total of 40,547 patients with Crohn’s disease-associated cancer (CDAC) were included in the meta-analysis (“inverse variance weighted” method).

Results

The incidence of CDAC in any CD patient was 0.8/1,000 person years duration (pyd) (CI, 0.6–1.0). The incidences of different carcinomas were: colorectal cancer 0.5/1,000 pyd (CI, 0.3–0.6), small bowel carcinoma 0.3/1,000 pyd (CI, 0.1–0.5), and cancers arising from CD-associated fistulae 0.2/1,000 pyd (CI, 0.0–0.4). Compared to the incidence in an age-matched standard population, the risk of colorectal cancer was increased by factor 2–3 and of small bowel cancer by factor 18.75, respectively. Mean patient age at diagnosis of CD-associated colorectal cancer was 51.5 years, thus 20 years earlier than in a standard population. The mean duration of CD until diagnosis of CDAC was 18.3 years. Duration of CD, age at diagnosis of CD, and anatomical area of CD involvement had no significant influence on cancer incidence.

Conclusions

CD is a risk factor for colorectal cancer, small bowel cancer, and fistula cancer; however, compared to ulcerative colitis, cancer risk is moderate.

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Title: Intestinal Cancer Risk in Crohn’s Disease: A Meta-Analysis
Authors: Mike Georg Laukoetter
Rudolf Mennigen
C. Mareike Hannig
Nani Osada
Emile Rijcken
Thorsten Vowinkel
Christian F. Krieglstein
Norbert Senninger
Christoph Anthoni
Matthias Bruewer
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-010-1402-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Intestinal Cancer Risk in Crohn’s Disease: A Meta-Analysis

Abstract

Aim of the study

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Aim of the study

Methods

Results

Conclusions

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