Published in:
01-04-2011 | Original Article
Prognostic Factors for Post-recurrence Survival in Esophageal Squamous Cell Carcinoma Patients with Recurrence after Resection
Published in: Journal of Gastrointestinal Surgery | Issue 4/2011
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Objective
The survival of recurrent esophageal cancer is poor. But reports regarding prognostic factors for post-recurrence survival are limited. We analyzed the recurrence pattern and the prognostic factors for post-recurrence survival in esophageal squamous cell carcinoma with recurrence after resection.
Methods
Two hundred sixty-eight patients were included. Tumor recurrence occurred in 115 (42.9%) patients. Recurrence pattern was classified as locoregional, distant, and combined recurrence. The post-recurrence survival was defined as the interval between initial recurrence and either death or the last follow-up.
Results
Mediastinum lymphadenopathy was the most common site for locoregional recurrence, whereas lung, liver, and bone were the most common sites for distant recurrence. The overall 1- and 2-year post-recurrence survival rates were 32.6% and 12.6% with a median survival after recurrence of 6.0 months. The independent prognostic factors included liver recurrence (HR = 2.255, 95%CI = 1.073–4.741, p = 0.032), time to recurrence ≤10 months (HR = 2.657, 95%CI = 1.438–4.911, p = 0.002), and no treatment for recurrences (HR = 2.745, 95%CI = 1.635–4.608, p < 0.001).
Conclusions
We identify liver recurrence, early recurrence, and no treatment for recurrence as risk factors for dismal post-recurrence survival.