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Journal of Natural Medicines
Published in: Journal of Natural Medicines 1/2020

01-01-2020 | Alkaloids | Original Paper

BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells

Authors: Mamiko Yano, Souichi Nakashima, Yoshimi Oda, Seikou Nakamura, Hisashi Matsuda

Published in: Journal of Natural Medicines | Issue 1/2020

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Abstract

Blood–brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine, N-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and N-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and N-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer’s disease, because of their activity and BBB permeability.
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Metadata
Title
BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells
Authors
Mamiko Yano
Souichi Nakashima
Yoshimi Oda
Seikou Nakamura
Hisashi Matsuda
Publication date
01-01-2020
Publisher
Springer Singapore
Published in
Journal of Natural Medicines / Issue 1/2020
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-019-01368-7

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