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01-07-2016 | Original Paper

New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition

Authors: Yoshimi Oda, Souichi Nakashima, Seikou Nakamura, Mamiko Yano, Masanori Akiyama, Kayo Imai, Tomohito Kimura, Akiko Nakata, Miyuki Tani, Hisashi Matsuda

Published in: Journal of Natural Medicines | Issue 3/2016

Abstract

The methanolic extract of Lawsonia inermis L. (henna) showed accelerative effects on nerve growth factor-induced neurite outgrowth in PC12 cells under non-fasting conditions. To elucidate the active constituents responsible for the neuronal differentiation, we conducted a search of the constituents and examined their accelerative effects on neurite outgrowth in PC12 cells. We isolated a new acetophenone glycoside, inermioside A, which exerted a significant accelerative effect on neurite outgrowth. We also confirmed the activities of nine known compounds, including quercetin and lalioside. In addition, we found that quercetin, one of the active constituents, increased Vav3 mRNA expression.

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Title: New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition
Authors: Yoshimi Oda
Souichi Nakashima
Seikou Nakamura
Mamiko Yano
Masanori Akiyama
Kayo Imai
Tomohito Kimura
Akiko Nakata
Miyuki Tani
Hisashi Matsuda
Publication date: 01-07-2016
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 3/2016
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-0974-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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