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01-07-2016 | Original Paper

γ-Lactam alkaloids from the flower buds of daylily

Authors: Takahiro Matsumoto, Seikou Nakamura, Souichi Nakashima, Tomoe Ohta, Mamiko Yano, Junichiro Tsujihata, Junko Tsukioka, Keiko Ogawa, Masashi Fukaya, Masayuki Yoshikawa, Hisashi Matsuda

Published in: Journal of Natural Medicines | Issue 3/2016

Abstract

Four new alkaloids, hemerocallisamines IV–VII, were isolated from the methanol extract of flower buds of daylily. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The absolute stereochemistry of the hemerocallisamines IV–VI was elucidated by the application of the modified Mosher’s method, HPLC analysis, and optical rotation. In the present study, the isolated alkaloids significantly inhibited the aggregation of Aβ42 in vitro. This is the first report about bioactive alkaloids with a γ-lactam ring from daylily. In addition, isolated nucleosides showed accelerative effects on neurite outgrowth under the non-fasting condition.

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Title: γ-Lactam alkaloids from the flower buds of daylily
Authors: Takahiro Matsumoto
Seikou Nakamura
Souichi Nakashima
Tomoe Ohta
Mamiko Yano
Junichiro Tsujihata
Junko Tsukioka
Keiko Ogawa
Masashi Fukaya
Masayuki Yoshikawa
Hisashi Matsuda
Publication date: 01-07-2016
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 3/2016
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0963-z

At a glance: The STEP trials

Springer Medicine

γ-Lactam alkaloids from the flower buds of daylily

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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