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01-07-2021 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Short Communication

Alterations of oral microbiota in patients with obstructive sleep apnea–hypopnea syndrome treated with continuous positive airway pressure: a pilot study

Authors: Chih-Yuan Ko, An-Ke Hu, Li Zhang, Xiao-Ling Lu, Yi-Ming Zeng

Published in: Sleep and Breathing | Issue 2/2022

Abstract

Purpose

Obstructive sleep apnea–hypopnea syndrome (OSAHS) is an independent risk factor for cardiovascular diseases, including hypertension. In our previous study, it was demonstrated that oral microbiota alteration in patients with OSAHS, particularly in the genera Aggregatibacter and Porphyromonas, may influence the development of hypertension. Continuous positive airway pressure (CPAP) is the main therapy for OSAHS and OSAHS-associated hypertension. However, the role of oral microbiota post CPAP treatment remains unknown.

Methods

We conducted 16S rDNA pyrosequencing and bioinformatic analyses to compare the bacterial composition of oral specimens from patients with OSAHS before and after overnight CPAP treatment.

Results

This approach enabled a relatively comprehensive description of oral microbiota, with decreases in Gemella and increases in Staphylococcus, f_Lachnospiraceae, Parabacteroides, and f_Ruminococcaceae after CPAP treatment.

Conclusion

Alteration of oral microbiota may shed new insight on the underlying pathogenesis of OSAHS-associated hypertension.

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Title: Alterations of oral microbiota in patients with obstructive sleep apnea–hypopnea syndrome treated with continuous positive airway pressure: a pilot study
Authors: Chih-Yuan Ko
An-Ke Hu
Li Zhang
Xiao-Ling Lu
Yi-Ming Zeng
Publication date: 01-07-2021
Publisher: Springer International Publishing
Keywords: Sleep Apnea
Oral Microbiota
Hypertension
Hypertension
Published in: Sleep and Breathing / Issue 2/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02428-7

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Purpose

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Results

Conclusion

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