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Sleep and Breathing
Published in: Sleep and Breathing 2/2022

19-06-2021 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Obstructive sleep apnea and the risk of mortality in patients with lung cancer: a meta-analysis

Authors: Meng-Xue Chen, Li-Da Chen, Ai-Ming Zeng, Xue-Jun Lin, Jian-Chai Huang, Jie-Feng Huang, Guo-Xiang Lai, Qi-Chang Lin

Published in: Sleep and Breathing | Issue 2/2022

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Abstract

Purpose

Prior reports have examined the relationship between obstructive sleep apnea (OSA) and the mortality rate of lung cancer. However, the findings remain controversial. The present meta-analysis was performed to assess the relationship between OSA and increased risk of mortality in patients with lung cancer.

Methods

PubMed, Web of Science, and Embase were systematically searched for the correlative studies. Data were analyzed and pooled to evaluate odds ratios (ORs) of lung cancer mortality related to OSA.

Results

From 249 identified studies, 3 met inclusion criteria and were analyzed, including 67 patients with lung cancer and comorbid OSA and 45 patients with lung cancer and no OSA. The meta-analysis indicated that OSA was not significantly correlated with mortality rate in lung cancer (OR = 2.005, 95% CI = 0.703 to 5.715, z = 1.30, p = 0.193). There was no significant publication bias according to Begg’s tests (p = 0.296) and Egger’s tests (p = 0.097).

Conclusion

This meta-analysis suggests that OSA is not significantly correlated with the mortality rate in lung cancer.
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Metadata
Title
Obstructive sleep apnea and the risk of mortality in patients with lung cancer: a meta-analysis
Authors
Meng-Xue Chen
Li-Da Chen
Ai-Ming Zeng
Xue-Jun Lin
Jian-Chai Huang
Jie-Feng Huang
Guo-Xiang Lai
Qi-Chang Lin
Publication date
19-06-2021
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 2/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-021-02416-x

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